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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12290569

    Methods and compositions using peptides and proteins with c-terminal elements

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12290596

    Compositions and methods for the treatment of opioid overdose

    Indivior UK Limited · Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12290566

    Dosing regimens and related compositions and methods

    Apellis Pharmaceuticals, Inc. · Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12290524

    Methods and compositions for testosterone production

    Maximus Health, Inc. · Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12290531

    Compositions targeting BCMA and methods of use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12290505

    Tissue factor-targeted antibody-drug conjugate

    SHANGHAI MIRACOGEN INC. · Granted Tue May 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. WO 2025096967

    REDIRECTION DE CAPSIDES D'AAV POUR CIBLAGE DU SYSTÈME NERVEUX CENTRAL

    BIOGEN MA INC [US] · Granted Thu May 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12297207

    Maytansinoid derivatives, conjugates thereof, and methods of use

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12297447

    Gene therapy for juvenile Batten disease

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12298315

    Systems and methods to identify and treat subjects at risk for obstetrical complications

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12297431

    Modulation of huntingtin expression

    Ionis Pharmaceuticals, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12297241

    Method to engineer transplantable human tissues

    The Regents of the University of California · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12296053

    Nanomaterials comprising triols

    Beam Therapeutics Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12296023

    Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof

    The Regents of the University of California · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12295362

    Formulations and processes for CAR T cell drug products

    Allogene Therapeutics, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12295931

    Levodopa dosing regimen

    AMNEAL PHARMACEUTICALS LLC · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12295909

    Adapter for use in a planetary mixer

    MEDISCA PHARMACEUTIQUE INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12295940

    Viral inhibitors, the synthesis thereof, and intermediates thereto

    Takeda Pharmaceutical Company Limited · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12297203

    Pyrrolopyrimidine ITK inhibitors

    Aclaris Therapeutics, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12296013

    Photosensitizing antibody-fluorophore conjugates

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12297279

    Compositions and methods for treating pain in subjects with rheumatoid arthritis

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12296048

    Polymer particles for neutrophil injury

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12295974

    Compositions and methods for transplantation of colon microbiota

    Regents of the University of Minnesota · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12298319

    Method for measuring alpha value of muscarinic M1 receptor positive allosteric modulators

    Takeda Pharmaceutical Company Limited · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12297300

    Hyaluronic acid-based zwitterionic polymer brush, preparation method thereof, and use thereof

    South China University of Technology · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12297465

    CBLB endonuclease variants, compositions, and methods of use

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12297509

    Biomarkers for predicting tumor response to and toxicity of immunotherapy

    MIRA DX, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12297452

    Methods or generating T-cells from stem cells and immunotherapeutic methods using the T-cells

    The Regents of the University of California · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12297243

    Methods and compositions for reducing the immunogenicity of chimeric notch receptors

    Cell Design Labs, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12297259

    Aspergillus antigen chimeric receptors and use thereof

    The Board of Regents of the University of Texas System · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12297257

    Multispecific antigen-binding molecules and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12297209

    Benzodiazepine derivatives as RSV inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12297182

    Compositions comprising an urolithin compound

    Amazentis SA · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12296066

    Methods of wound healing with Serp-1 polypeptides

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12297202

    RIP1K inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12297186

    Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5

    AGOMAB SPAIN, S.L.U. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12296047

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12296025

    AAV capsid variants and uses thereof

    VOYAGER THERAPEUTICS, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12296004

    Recombinant virus with diminished latency and methods of using same

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12295929

    Intravenous baclofen formulations and treatment methods

    Regents of the University of Minnesota · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12295971

    Compositions and methods for enhancing adoptive T cell therapeutics

    The Regents of the University of California · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12295941

    Viral inhibitors, the synthesis thereof, and intermediates thereto

    Takeda Pharmaceutical Company Limited · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12295394

    Water-soluble additive composition

    SUMITOMO BAKELITE CO., LTD. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12296050

    Pharmaceutical compositions comprising maralixibat and uses thereof

    MIRUM PHARMACEUTICALS, INC. · Granted Tue May 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12305189

    Compositions and methods for delivery of AAV

    VOYAGER THERAPEUTICS, INC. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12303551

    Cellular immunotherapy compositions and uses thereof

    Cero Therapeutics Holdings, Inc. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12303479

    Chloride intracellular channel 1 for regulation of food intake

    The Regents of the University of California · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12303724

    Non-adult human dosing of anti-CD30 antibody-drug conjugates for treatment of hematological or lymphoid cancer

    Takeda Pharmaceutical Company Limited · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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