Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2044

Annual patent cliff calendar for 2044 — US pharmaceutical patents by expiration date.

Patents
1,766

Quick answer

1,766 indexed pharmaceutical patents have expiration dates in 2044. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12018015

    Methods and compositions for targeting PD-L1

    Aligos Therapeutics, Inc. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12018074

    Anti CCL24 (eotaxin2) antibodies for use in the treatment of hepatic diseases

    CHEMOMAB LTD. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12017066

    Modulation of extracellular vesicles with electrical stimulation

    Regents of the University of Minnesota · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12018017

    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof

    Enanta Pharmaceuticals, Inc. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 12018081

    Photoconjugation reactions for modification of specific proteins on live cells

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 12018259

    Treatment of liver diseases with cell death inducing DFFA like effector B (CIDEB) inhibitors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 12018298

    PH20 polypeptide variants, formulations and uses thereof

    HALOZYME, INC. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 12016908

    Compositions and methods for treating hemoglobinopathies

    Beam Therapeutics Inc. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 12016973

    Methods and systems for augmenting immune system responses

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 12018045

    17-beta-hydroxywithanolides and use thereof in treating cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 12018082

    Methods and agents for treating infections

    The Regents of the University of California · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 12018260

    Tunable Reversir™ compounds

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 12016867

    Methods of treating inflammation and/or pain

    Semnur Pharmaceuticals, Inc. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 12016877

    Anticancer compositions and methods for making and using them

    The Regents of the University of California · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 12016848

    Roflumilast formulations with an improved pharmacokinetic profile

    ARCUTIS BIOTHERAPEUTICS, INC. · Granted Tue Jun 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. WO 2024133935

    EXCIPIENTS DE CONJUGAISON PROTÉIQUES

    ABLYNX NV [BE] · Granted Thu Jun 27 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 22 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 12024486

    Lipocationic dendrimers and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 12023309

    Enhanced delivery epinephrine compositions

    Aquestive Therapeutics, Inc. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 12023359

    Phospholipid compositions for delivery of therapeutic compounds

    Aker BioMarine Human Ingredients AS · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 12023391

    Alpha(v)beta(6) integrin-binding peptides and methods of use thereof

    The Regents of the University of California · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 12023410

    Micro/nanobubble solutions for tissue preservation and generation thereof

    The Regents of the University of California · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 12023335

    Method for treating pancreatic cancer

    PTC THERAPEUTICS, INC. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 12023389

    Compositions that target tumor-associated macrophages and methods of use therefor

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 12023348

    EGR1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions

    The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 12023343

    Thermo-kinetic mixing for pharmaceutical applications

    The Board of Regents of the University of Texas System · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 12023337

    Methods of treating cancer

    Corvus Pharmaceuticals, Inc. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 12024509

    Therapeutic compounds as inhibitors of the orexin-1 receptor

    C4X Discovery Limited · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 12023355

    Programmed death 1 ligand 1 (PD-L1) binding proteins and methods of use thereof

    Iovance Biotherapeutics, Inc. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 12023388

    Detection and treatment of caries and microcavities with nanoparticles

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 12025615

    Methods of classifying response to immunotherapy for cancer

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 12023383

    Lipid compositions

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 12023394

    Vesicle-coated fibers made from crosslinked lipids

    The Regents of the University of California · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 12024512

    Cocrystal

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 12024505

    Heterocyclic compounds useful as modulators of acetylcholine receptors

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 12024570

    Anti-CTLA-4 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 12024556

    Anti-Staphylococcus antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 12024718

    Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Jul 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. WO 2024141977

    CELLULES TUEUSES NATURELLES MODIFIÉES ET PROCÉDÉS ASSOCIÉS

    ASTELLAS PHARMA INC [JP] · Granted Thu Jul 04 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 29 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 12029816

    Compositions and methods of making brittle-matrix particles through blister pack freezing

    The Board of Regents of the University of Texas System · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 12030953

    Chimeric antigen receptors, compositions, and methods

    Regents of the University of Minnesota · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 12029755

    Carbon monoxide-based therapies and implantable devices for the treatment of vascular disease

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 12030958

    Compositions and methods of use of alpha-1 antitrypsin fusion polypeptides

    The Regents of the University of Colorado · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 12031008

    Dendritic macroporous hydrogels prepared by crystal templating

    The Board of Regents of the University of Texas System · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 12029787

    Method for generating recombinant poxviruses

    UNIVERSITY OF CONNECTICUT · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 12030910

    Compounds and methods for the modulation of proteins

    Ionis Pharmaceuticals, Inc. · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 12030869

    5-membered heteroaryl carboxamide compounds for treatment of HBV

    ASSEMBLY BIOSCIENCES, INC. · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 12030896

    PIKfyve inhibitors

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 12030897

    Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof

    Medshine Discovery Inc. · Granted Tue Jul 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2044?

1,766 published patents in our USPTO index have expiration dates falling in calendar year 2044.