Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11590223

    Dosing strategy that mitigates cytokine release syndrome for therapeutic antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11591350

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11590204

    Use of C-type natriuretic peptide variants to treat skeletal dysplasia

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11590135

    Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists

    Corcept Therapeutics Incorporated · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11590113

    Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator

    Corcept Therapeutics Incorporated · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11591319

    Small molecule inducers of autophagy

    The Board of Regents of the University of Texas System · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11590154

    Triple antibiotic fixed-dose combination products, dosing regimen, methods, and kits for treating pulmonary non-tuberculosis mycobacterial infections

    RedHill Biopharma Ltd. · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11590092

    Skin probiotic

    The Regents of the University of California · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11590205

    Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents

    XERIS PHARMACEUTICALS, INC. · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11591372

    Recombinant human/bovine parainfluenza virus 1 (HPIV1) expressing a chimeric RSV/HPIV1 F protein and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11591304

    SLC26A3 inhibitors and use thereof

    The Regents of the University of California · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11591402

    Neutralizing antibodies to the alpha v beta 8 integrin complex for immunotherapy

    The Regents of the University of California · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11594345

    Method for producing Ac-225 from Ra-226

    Ion Beam Applications · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11591330

    HIF-2a small-molecule inhibitor and use thereof

    China Medical University · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11590085

    Compositions and methods for organ specific delivery of nucleic acids

    The Board of Regents of the University of Texas System · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11590197

    Agents targeting inhibitor of apoptosis proteins

    The Regents of the University of California · Granted Tue Feb 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. IL 300192

    Manufacturing of dimeric contrast agents

    BRACCO IMAGING SPA [IT] · Granted Wed Mar 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Feb 24 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11596624

    Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11597774

    Antibody variable domains and antibody constructs

    The Board of Regents of the University of Texas System · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11598774

    Methods of diagnosis and treatment of Alzheimer's Disease

    The Regents of the University of California · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11596690

    Stabilized formulations containing anti-IL-33 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11596696

    Combination therapy with an anti-CD25 antibody-drug conjugate

    ADC THERAPEUTICS SA · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11597727

    Inhibitors of integrin alpha 2 beta 1 and methods of use

    The Regents of the University of California · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11597853

    Coatings containing polymer modified enzyme for stable self-cleaning of organic stains

    Regents of the University of Minnesota · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11597707

    CGAS antagonist compounds

    The Board of Regents of the University of Texas System · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11598782

    Biomarkers and methods for detection of seizures and epilepsy

    Cognizance Biomarkers, LLC · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11596611

    Hepatitis B antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11596671

    Gene therapy of hemophilia B using viral vectors encoding recombinant fix variants with increased expression

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11596610

    Compositions in support of health and mental accuity

    HIGHER OPTIONS GLOBAL, INC. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11597701

    Integrin ligands and uses thereof

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11597928

    Nucleic acid complex

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11597748

    Peptide having cytoprotective effect against environmental pollutant and use thereof

    CAREGEN CO., LTD. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11596635

    Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11596694

    Compositions and methods for predicting response to NaPi2b-targeted therapy

    Mersana Therapeutics, Inc. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11598015

    Fabrication of dendritic structures and tags

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11596660

    Methods of treating bladder cancer

    CG ONCOLOGY, INC. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11596585

    Composition for the prevention of microbial growth

    Eikonic R&D Pty Ltd · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11596633

    SHP2 inhibitor compositions and methods for treating cancer

    Revolution Medicines, Inc. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11596711

    Solubilization of antigen components for removal from tissues

    The Regents of the University of California · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11597773

    CD6 antibody for treatment of T-cell mediated diseases or disorders

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11596909

    System and method for droplet formation and manipulation using ferrofluids

    The Regents of the University of California · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11597765

    Use of semaphorin-4D binding molecules for the treatment of Rett syndrome

    VACCINEX, INC. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11597749

    Peptide compositions and methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11597916

    Nicotine degrading enzyme variants

    The Board of Regents of the University of Texas System · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11597924

    Genome editing systems comprising repair-modulating enzyme molecules and methods of their use

    Editas Medicine, Inc. · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11597948

    Use of ANP32 protein in maintaining the polymerase activity of influenza virus in hosts

    Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (China Animal Health and Epidemiology Center Harbin Branch Center) · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11596688

    Predicting outcome of treatment with an anti-α4β7 integrin antibody

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. CA 3230406

    UTILISATION DE MICRO-ARN POUR LA REGULATION NEGATIVE DE L'EXPRESSION DE TRANSGENES CYTOTOXIQUES PAR LE VIRUS DE LA VACCINE ANKARA MODIFIE (MVA)

    BAVARIAN NORDIC AS [DK] · Granted Thu Mar 09 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 04 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.