Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11571389

    Delivery devices and methods for making the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11571440

    Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion

    Jazz Pharmaceuticals Ireland Limited · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11572408

    Treatment of cancer with a semaphorin-4D antibody in combination with an epigenetic modulating agent

    VACCINEX, INC. · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11571482

    Human antibodies to S. aureus Hemolysin A toxin

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11571444

    Enhancement of MSC immunomodulatory properties by treprostinil

    United Therapeutics Corporation · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11571636

    Methods for quantitating individual antibodies from a mixture

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11572367

    Antiviral heterocyclic compounds

    Enanta Pharmaceuticals, Inc. · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11571445

    Genetically engineered hematopoietic stem cells and uses thereof

    Vor Biopharma Inc. · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11571485

    Peptides and antibodies for detecting changes in alzheimer's disease brain and methods of use thereof

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11571484

    Compositions that target tumor-associated macrophages and methods of use therefor

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11571538

    Gas delivery devices

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11572372

    Anti-HBVtetrahydroisoxazolo[4,3-c]pyridine compounds

    Medshine Discovery Inc. · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11571446

    Gut microbiota and treatment of cancer

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Feb 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. EP 4125971

    BAKTERIENSTÄMME, ZUSAMMENSETZUNGEN DAVON UND VERWENDUNG DAVON IN EINEM VERFAHREN ZUR BEHANDLUNG VON VITAMIN-D-MANGEL UND DAMIT ASSOZIIERTEN ERKRANKUNGEN

    SOFAR SPA [IT] · Granted Wed Feb 08 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Feb 03 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 2023040008

    ANTI-HER2 POLYPEPTIDES DERIVATIVES AS NEW DIAGNOSTIC MOLECULAR PROBES

    BRACCO IMAGING SPA [IT] · Granted Thu Feb 09 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 04 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11576883

    L-DOPA microbiome therapy

    The Board of Regents of the University of Texas System · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11576871

    Formulations of cysteamine and cystamine

    The Regents of the University of California · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11578066

    Fluoroalkyl-oxadiazoles and uses thereof

    Tenaya Therapeutics, Inc. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11576951

    Stable therapeutic compositions in aprotic polar solvents and methods of manufacturing the same

    XERIS PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11576984

    Genetically modified mouse with humanized immunoglobulin heavy chain constant region genes and method of using

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11578062

    Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

    Vertex Pharmaceuticals Incorporated · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11578078

    Heterocyclic RIP1 inhibitory compounds

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11576580

    Apparatus, systems and methods for intraoperative imaging

    The Regents of the University of California · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11576924

    Compounds for the prevention and treatment of diseases and the use thereof

    Galectin Sciences, LLC · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11576948

    Long-acting VEGF inhibitors for intraocular neovascularization

    The Regents of the University of California · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11578081

    Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof

    Medshine Discovery Inc. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11578126

    Chimeric antigen receptor (CAR) comprising a CD19-binding domain

    AUTOLUS LIMITED · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11578309

    Universal donor cells

    CRISPR THERAPEUTICS AG · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11578371

    Biomarkers for predicting tumor response to and toxicity of immunotherapy

    MIRA DX, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11578313

    CRISPR-Cas effector polypeptides and methods of use thereof

    The Regents of the University of California · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11578315

    Truncated guinea pig L-asparaginase variants and methods of use

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11576889

    Methods of identifying and treating patients with HIF-2 inhibitor resistance

    The Board of Regents of the University of Texas System · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11576863

    Formulation of an antibody and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11576907

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Corcept Therapeutics Incorporated · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11576983

    Treatments for retinal disease

    4D MOLECULAR THERAPEUTICS INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11576356

    Genetically modified non-human animals and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11578338

    Hemipteran active insecticidal protein

    CORTEVA AGRISCIENCE LLC · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11576744

    Thermosensitive bio-adhesive hydrogel for removal of ureteral and renal stones

    The Regents of the University of California · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11576922

    CD73 inhibitors

    ORIC PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11576982

    Nipah virus envelope pseudotyped lentiviruses and methods of their use

    The Regents of the University of California · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11578135

    Multispecific antigen-binding molecules binding to a target and an internalizing effector protein that is CD63 and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11576971

    Method of filling a container with no headspace

    Coherus BioSciences, Inc. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11578127

    Anti-Fc epsilon-R1 alpha (FcεR1α) antibodies, bispecific antigen-binding molecules that bind FcεR1α and CD3, and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11579150

    Methods for characterizing disulfide bonds

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11578103

    Nucleic acids encoding Zika virus-like particles and their use in Zika virus vaccines and diagnostic assays

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 14 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 09 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11584933

    RNA interference in ocular indications

    Phio Pharmaceuticals Corp. · Granted Tue Feb 21 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 16 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11583542

    Compositions of bile acids and phenylbutyrate compounds

    Amylyx Pharmaceuticals, Inc. · Granted Tue Feb 21 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 16 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11584733

    Selective histone deacetylase inhibitors for the treatment of human disease

    Shuttle Pharmaceuticals, Inc. · Granted Tue Feb 21 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 16 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.