Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11305009

    Recombinant virus with diminished latency and methods of using same

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11304979

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11304916

    Methods and compositions for the treatment of Shiga Toxicosis

    The Board of Regents of the University of Texas System · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. WO 2022081033

    OPICAPONE ET LÉVODOPA POUR LE TRAITEMENT DE LA MALADIE DE PARKINSON

    BIAL PORTELA & Cª S A [PT] · Granted Thu Apr 21 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 16 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 2022119410

    PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMORPHIC FORMS ALPHA, BETA, AND GAMMA OF RIFAXIMIN

    ALFASIGMA SPA [IT] · Granted Thu Apr 21 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 16 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11311545

    Compositions and methods for the delivery of therapeutics

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11311549

    Corticotropin releasing factor receptor antagonists

    SPRUCE BIOSCIENCES, INC. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11311532

    High dosage valbenazine formulation and compositions, methods, and kits related thereto

    Neurocrine Biosciences, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11311486

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11311503

    Sterile aqueous choline salt compositions

    PROTARA THERAPEUTICS, INC. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11311485

    Self-assembled particles for targeted delivery of immunomodulators to treat autoimmunity and cancer

    Northwestern University · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11312692

    Polymorphic compounds and uses thereof

    Aldeyra Therapeutics, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11311560

    Cyclic plasmenylethanolamines

    Med-Life Discoveries LP · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11311544

    Treatment of congenital adrenal hyperplasia

    Neurocrine Biosciences, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11311551

    Use of H3K9me3 modulation for enhancing cognitive function

    The Regents of the University of California · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11311578

    Restimulation of cryopreserved tumor infiltrating lymphocytes

    Iovance Biotherapeutics, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11311613

    Development of agonist epitopes of the human papillomavirus

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11312953

    Compositions and methods of nucleic acid-targeting nucleic acids

    Caribou Biosciences, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11312714

    Compositions and methods for modulating hair growth

    The Regents of the University of California · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11312786

    Oncofetal antigen binding proteins and related compositions and methods

    Aptevo Research and Development LLC · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11311574

    Methods and compositions for targeted cleavage and recombination

    Sangamo Therapeutics, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11311624

    Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11311541

    Treatment of GVHD

    Regents of the University of Minnesota · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11312695

    Nutrients to enhance load-induced muscle hypertrophy

    The Regents of the University of California · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11312749

    Heterotandem bicyclic peptide complex

    BicycleTx Limited · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11312756

    Engineered potent cytotoxic stapled BH3 peptides

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11312939

    Constructs for chimeric antigen receptors

    Carisma Therapeutics Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11312964

    Compositions and methods for modulating growth hormone receptor expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11313868

    Methods of detecting anti-folic acid antibodies and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11312962

    Modulators of diacyglycerol acyltransferase 2 (DGAT2)

    Ionis Pharmaceuticals, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11312787

    Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis

    The Regents of the University of California · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11311581

    Combination comprising spirulina and palmitoylethanolamide and/or salts or pharmaceutically acceptable derivatives thereof and their formulations, for use in the prevention and/or in the treatment of hyperactivated tissue conditions

    AGAIN LIFE ITALIA SRL · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11311547

    Antiviral prodrugs and nanoformulations thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11311507

    Enterically coated cysteamine, cystamine and derivatives thereof

    The Regents of the University of California · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11311517

    Combination of small molecule CD-47 inhibitors with other anti-cancer agents

    Aurigene Discovery Technologies Limited · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11312957

    Modified iRNA agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11311526

    Radiation mitigator and method of use thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Apr 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. EP 3986378

    PHARMAZEUTISCHE ZUSAMMENSETZUNGEN IN FORM VON GEL MIT XYLOGLUCAN UND ALKOHOLEN ZUR KONTROLLIERTEN FREISETZUNG VON WIRKSTOFFEN

    ALFASIGMA SPA [IT] · Granted Wed Apr 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Apr 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11318100

    Storage stable sincalide formulations

    MAIA PHARMACEUTICALS, INC. · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11318133

    Modulators of integrated stress response pathway

    PRAXIS BIOTECH LLC · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11319302

    PRC1 inhibitors and methods of treatment therewith

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11318211

    Dosage regimes for the administration of an anti-CD19 ADC

    ADC THERAPEUTICS SA · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11318164

    Immunotherapeutic treatment method using an interleukin-2 receptor beta-selective agonist in combination with adoptive cell transfer therapy

    Nektar Therapeutics · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11318091

    Gastroretentive dosage forms for sustained drug delivery

    Amneal Complex Products Research LLC · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11317888

    Non-invasive method for pressure measurement

    GE Precision Healthcare LLC · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11318098

    Liposomal apparatus and manufacturing methods

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11317968

    Methods and compositions for tissue adhesives

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11318196

    Attenuated mutant dengue viruses comprising a mutation in the NS5 non-structural protein

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.