Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2041

Annual patent cliff calendar for 2041 — US pharmaceutical patents by expiration date.

Patents
2,000

Quick answer

2,000 indexed pharmaceutical patents have expiration dates in 2041. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11103572

    Thermal inactivation of rotavirus

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 11103532

    Chimeric protein

    AUTOLUS LIMITED · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 11103514

    Treatment of muscular dystrophy

    Corcept Therapeutics Incorporated · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 11103528

    Slow release calcium composition

    United States of America as represented by the Secretary of the Air Force · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 11103523

    Self-assembled brush block copolymer-nanoparticles for drug delivery

    UNIVERSITY OF CONNECTICUT · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 11103520

    Analogs of N-acetlyglucosamine and uses thereof

    The Regents of the University of California · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 11103504

    Combination of a DNA condensation-inducing compound and an Eis inhibitor for antibiotic treatment

    ACADEMISCH MEDISCH CENTRUM · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 11104957

    Compositions and methods for treating cancers

    APTOSE BIOSCIENCES INC. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 11103479

    Small organic molecules for use in the treatment of neuroinflammatory disorders

    The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 11103461

    Process for encapsulating soluble biologics, therapeutics, and imaging agents

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 11103460

    Fabrication methods for nanodelivery systems for long term controlled delivery of active pharmaceutical ingredients

    The Board of Regents of the University of Texas System · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 11103436

    Peptide exhibiting wrinkle-improving activity and uses thereof

    CAREGEN CO., LTD. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 11102961

    Non-human animals having a humanized lymphocyte-activation gene 3

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 11103454

    Wax foamable vehicle and pharmaceutical compositions thereof

    Vyne Therapeutics Inc. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 11104719

    Recombinant clusterin and use thereof in the treatment and prevention of disease

    The Board of Regents of the University of Texas System · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 11104689

    Influenza virus replication inhibitor and use thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 11104684

    Dimers of covalent NFKB inhibitors

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 11103552

    High concentration VEGF receptor fusion protein containing formulations

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 11103541

    Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them

    Finch Therapeutics Holdings LLC · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 11103513

    Natural combination hormone replacement formulations and therapies

    Compass Therapeutics LLC · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 11103472

    Oral suspensions comprising a non-steroidal anti-inflammatory drug (NSAID)

    Infirst Healthcare Limited · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 11103462

    Protein nanocapsules with detachable zwitterionic coating for protein delivery

    The Regents of the University of California · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 11104918

    Universal donor cells

    CRISPR THERAPEUTICS AG · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 11104737

    ACVR2A-specific antibody and method of treatment of muscle atrophy

    Rigel Pharmaceuticals, Inc. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 11104730

    Methods of treating eye disorders with APLNR antagonists and VEGF inhibitors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 11104729

    Anti-IL-33 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 11104901

    Brush polymer-assisted compaction of oligonucleotides

    Northwestern University · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 11104715

    Methods for producing aflibercept in chemically defined media having reduced aflibercept variants

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 11104708

    Articles comprising a silk polypeptide for antigen delivery

    Ludwig-Maximilians-Universitat Munchen · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 11104706

    Ang (1-7) derivative oligopeptides and methods for using and producing the same

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Aug 31 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. IT 202000004582

    COMPOSIZIONE FARMACEUTICA UTILE PER IL TRATTAMENTO E LA PREVENZIONE DELL’ATROFIA E DELLA SECCHEZZA VAGINALE.

    ALFASIGMA SPA [IT] · Granted Mon Sep 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sun Sep 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 11110150

    Complexes of IL-15 and IL-15Ralpha and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 11110173

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 11110154

    Methods and compositions for treating Huntington's Disease

    Sangamo Therapeutics, Inc. · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 11110134

    Direct-fed microbials

    MICROBIAL DISCOVERY GROUP, LLC · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 11111310

    Chimeric polypeptides and methods of altering the membrane localization of the same

    Cell Design Labs, Inc. · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 11111238

    Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

    Lead Discovery Center GmbH · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 11110178

    Antibody adjuvant conjugates

    Bolt Biotherapeutics, Inc. · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 11110177

    ASH1L degraders and methods of treatment therewith

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 11110108

    Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 11110095

    Pyrimidine compounds as JAK kinase inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 11110092

    Methods of treating hematologic cancers

    BioCryst Pharmaceuticals, Inc. · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 11110089

    Pyridazinones and their use in the treatment of cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 11110086

    Compounds useful as inhibitors of ATR kinase and combination therapies thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 11110080

    Small molecule inhibitors of bacterial efflux pumps and methods of using same

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 11111222

    Hydroxyeicosatrienoic acid compounds and their use as therapeutic agents

    The Regents of the University of California · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 11110103

    Inhibitors of glucocorticoid receptor

    ORIC PHARMACEUTICALS, INC. · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 11110090

    Aminopyrimidines as ALK inhibitors

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2041?

2,000 published patents in our USPTO index have expiration dates falling in calendar year 2041.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.