Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. WO 2013169458

    COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES DE TRAITEMENT, DE CONTRÔLE, D'AMÉLIORATION, OU D'INVERSION DES TROUBLES DE LA KÉRATOCONJONCTIVITE SÈCHE

    BAUSCH & LOMB [US] · Granted Thu Nov 14 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 09 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8586762

    Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8586713

    Readily isolated bispecific antibodies with native immunoglobulin format

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8586536

    Neprilysin inhibitors

    Theravance, Inc. · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8586055

    DNA immunization protocols

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8586626

    Metabolites of wortmannin analogs and methods of using the same

    Arizona Board of Regents, Acting on Behalf of the University of Arizona · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8586044

    Treatment of chronic pelvic pain syndrome

    Northwestern University · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8586006

    Organ-specific proteins and methods of their use

    INTEGRATED DIAGNOSTICS, INC. · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8586046

    Methods and compositions for mycoplasma pneumoniae exotoxins

    The Board of Regents of the University of Texas System · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8586291

    Mutations in the Bcr-Abl tyrosine kinase associated with resistance to ST1-571

    The Regents of the University of California · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8586308

    Genetic markers of mental illness

    SureGene LLC · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8586317

    Methods of diagnosing hypophosphatemic disorders

    Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche Genetik · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8586363

    TAL effector-mediated DNA modification

    Regents of the University of Minnesota · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8586526

    DNA-binding proteins and uses thereof

    Sangamo Biosciences, Inc. · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8586553

    Therapies for cancer using RLIP76

    The Board of Regents of the University of Texas System · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8586610

    Methods for the administration of iloperidone

    VANDA PHARMACEUTICALS INC. · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8586571

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8586589

    Piperidine and piperazine phenyl sulfonamides as modulators of ion channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8586615

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8586681

    Multi-arm block copolymers as drug delivery vehicles

    Nektar Therapeutics · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8586711

    Polymer-factor IX moiety conjugates

    Nektar Therapeutics · Granted Tue Nov 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8592456

    IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation

    4SC DISCOVERY GMBH · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8591890

    Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality

    University of Connecticut Health Center · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8592602

    Processes for producing cycloalkylcarboxamido-pyridine benzoic acids

    Vertex Pharmaceuticals Incorporated · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8592384

    Micro-RNA's that regulate muscle cells

    The Board of Regents of the University of Texas System · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8591862

    Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8592380

    Aerosol foams comprising clindamycin phosphate

    Precision Dermatology, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8591889

    Human monoclonal antibodies specific for CD22

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8591922

    Gamma-hydroxybutyrate compositions and their use for the treatment of disorders

    Jazz Pharmaceuticals, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8591964

    Vaccinium species compositions

    Denali Biotechnologies, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8591929

    Hydrogel implants with varying degrees of crosslinking

    Covidien LP · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8591950

    Hydrogel implants with varying degrees of crosslinking

    Covidien LP · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8591891

    Monoclonal antibodies against ANGPTL4

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8592379

    Metastin derivative and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8592389

    MicroRNA (miRNA) and downstream targets for diagnostic and therapeutic purposes

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8592431

    Fused ring compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8592442

    Nilotinib HCl crystalline forms

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8592402

    Compounds as lysophosphatidic acid receptor antagonists

    AMIRA PHARMACEUTICALS, INC. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8592452

    Cyclic amine compound

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8592453

    Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8592454

    Nitrogen-containing heterocyclic compound and use of same

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8592570

    Compositions and methods for inhibiting expression of an RNA from West Nile virus

    Alnylam Pharmaceuticals, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8592464

    Nitric oxide furoxan derivative compounds endowed with antitumoral activity

    HUMANITAS MIRASOLE S.P.A. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8592571

    RNAi modulation of APOB and uses thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8592577

    Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8592596

    Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound

    Theravance, Inc. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8592597

    Pyrrole compounds

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8592598

    Method of producing a crystal of an imidazole compound

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.