Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8563022

    Particles for cell targeting

    The Board of Regents of the University of Texas System · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8563035

    Oral tablet compositions of dexlansoprazole

    Sanovel Ilac Sanayi Ve Ticaret Anomin Sirketi · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8563039

    Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions

    Anika Therapeutics S.r.l. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8563314

    Methods and compositions for modulating PD1

    Sangamo Biosciences, Inc. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8563503

    Antibiotic, its nucleotide sequence, methods of construction and uses thereof

    PROTEIN DESIGN LAB, LTD. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8563515

    Tight junction protein modulators and uses thereof

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8563569

    Compositions and methods for inhibition of the JAK pathway

    Rigel Pharmaceuticals, Inc. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8563575

    Fused heterocyclic compounds

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8563573

    Azaindole derivatives as CFTR modulators

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8563576

    Tri-cyclic pyrazolopyridine kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8563593

    Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8563599

    Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof

    THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF AGRICULTURE · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8563614

    Use of treprostinil to treat neuropathic diabetic foot ulcers

    United Therapeutics Corporation · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8563691

    Lysosomal targeting peptides and uses thereof

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8563618

    Skin external preparation having excellent stability

    KURARAY CO., LTD. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8563692

    Interferon-antibody fusion proteins demonstrating potent apoptotic and anti-tumor activities

    The Regents of the University of California · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8563651

    Method involving 1-benzotriazolyl carbonate esters of poly(ethylene glycol)

    Nektar Therapeutics · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8563730

    Pyrazole and fused pyrazole glucokinase activators

    Takeda San Diego, Inc. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8563731

    Mesylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]jamino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as agonist of the β2 adrenergic receptor

    Almirall, S.A. · Granted Tue Oct 22 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. EP 2651400

    ORALE RETARD-DARREICHUNGSFORMEN VON SCHWER LÖSLICHEN ARZNEIMITTELN UND IHRE VERWENDUNG

    CELGENE CORP [US] · Granted Wed Oct 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Oct 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. CA 2870399

    POLYPEPTIDES DE PROFILINE VEGETALE DESTINES A ETRE UTILISES DANS L'IMMUNOTHERAPIE NON SPECIFIQUE D'ALLERGIES

    ALK ABELLO AS [DK] · Granted Thu Oct 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8568977

    Compositions and methods for diagnosis and treatment of tumors

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8569028

    Method for encapsulation of microparticles

    The United States of America, as represented by the Secretary of the Agriculture · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8569379

    Use of rasagiline for the treatment of olfactory dysfunction

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8569380

    Oligomer-tricyclic conjugates

    Nektar Therapeutics · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8568769

    Particle-containing complex porous materials

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8568713

    Super fast-acting insulin compositions

    HALOZYME, INC. · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8568721

    Method of treating rheumatoid arthritis with an anti-IL-6R antibody

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8568739

    Antigenic chimeric tick-borne encephalitis virus/dengue virus type 4 recombinant viruses

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8569225

    Targeting complement factor H for treatment of diseases

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8569337

    Tri-cyclic pyrazolopyridine kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8569351

    Dual-acting benzyl triazole antihypertensive agents having angiotensin II type receptor antagonist activity and neprilysin-inhibition activity

    Theravance, Inc. · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8569249

    Method for inhibiting activation of macrophages

    China Medical University · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8569377

    Methods for treating spinal cord injury with a compound that inhibits a NCCA-ATP channel

    The United States of America as represented by the Department of Veteran Affairs · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8569253

    Methods and compositions for gene inactivation

    Sangamo Biosciences, Inc. · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8569242

    Method of treating degenerative disorders of the nervous system

    The Regents of the University of California · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8569343

    Oligomer-opioid agonist conjugates

    Nektar Therapeutics · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8568756

    Inhibition of quorum sensing-mediated processes in bacteria

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8569448

    NMDAR biomarkers for diagnosis and treatment of traumatic brain injury and other disorders

    GRACE LABORATORIES, LLC · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8569340

    AMPK-activating piperidinyloxypyiridine carboxamide and sulfonamide compounds and methods for using the same

    Rigel Pharmaceuticals, Inc. · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8568714

    Lys K endolysin is synergistic with lysostaphin against MRSA

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8568705

    Method for preparing branched functionalized polymers using branched polyol cores

    Nektar Therapeutics · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8569320

    Topical composition for the treatment of actinic keratosis

    Almirall Hermal GmbH · Granted Tue Oct 29 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. EP 2656851

    Semuloparin zur Verbesserung der Überlebenschance von Krebspatienten

    AVENTIS PHARMA SA [FR] · Granted Wed Oct 30 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Oct 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 2013289070

    Use of Levocabastine for Modulating Generation of Pro-Inflammatory Cytokines

    BAUSCH & LOMB [US] · Granted Thu Oct 31 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 26 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8575192

    Quinolinone-carboxamide compounds as 5-HT4 receptor agonists

    Theravance, Inc. · Granted Tue Nov 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8575375

    Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Nov 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8574545

    Labeled iodinated tropane formulation

    Alseres Pharmaceuticals, Inc. · Granted Tue Nov 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.