Saturday, July 11, 2026

Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

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  1. POST Triheptanoin

    Ultragenyx UK Limited

    Frontal Lobe Hypometabolism

    phase 2 small molecule completed

    1 trial
  2. POTASSIUM IODIDE

    Cellectar Biosciences

    Waldenstrom Macroglobulinemia

    phase 2 small molecule active

    1 trial
  3. POTELIGEO 4 mg/mL concentrate for solution for infusion

    KYOWA KIRIN AUSTRALIA PTY LTD

    Mycosis fungoides/Sezary syndrome recurrent

    phase 2 small molecule active

    1 trial
  4. PPRS

    BRIGHT MINDS BIOSCIENCES INC.

    Drug Use

    phase 2 other completed

    1 trial
  5. PPY988A

    Novartis Pharmaceuticals

    Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in participants already treated with GT005 in the previous studies GT005-01 (FOCUS), GT005-02 (EXPLORE) and GT005-03 (HORIZON).

    phase 2 small molecule active

    1 trial
  6. PRAM9

    Xeris Biopharma Holdings

    Diabetes Mellitus, Type 1

    phase 2 small molecule completed

    1 trial
  7. PRAVASTATIN

    The George Institute

    Patients with severe and radio-induced breast fibrosis after breast cancer

    phase 2 small molecule active

    1 trial
  8. PRAX-114-231

    Chongqing Precision Biotech Co., Ltd

    Essential Tremor

    phase 2 small molecule terminated

    1 trial
  9. PRAX-222 - Initial Dose

    Chongqing Precision Biotech Co., Ltd

    SCN2A-DEE

    phase 2 small molecule active

    1 trial
  10. PRAX-628

    Chongqing Precision Biotech Co., Ltd

    Focal onset seizures or primary generalized tonic-clonic seizures

    phase 2 small molecule active

    1 trial
  11. PRENUMBRA

    Clinuvel Europe Limited

    Arterial Ischaemic Stroke (AIS)

    phase 2 small molecule active

    1 trial
  12. PRENUMBRA

    Clinuvel Europe Limited

    Healthy volunteers

    phase 2 small molecule active

    1 trial
  13. PRENUMBRA

    Clinuvel Europe Limited

    Parkinson's Disease

    phase 2 small molecule active

    1 trial
  14. PRESTO

    The George Institute

    T1-T2N0 esophageal adenocarcinoma including gastroesophageal junction (GEJ) with indication for radical surgery

    phase 2 small molecule active

    1 trial
  15. PRO RCT GRAM 2022

    Lacuna Pharma Pty Ltd

    allergic rhinoconjunctivitis caused due to exposure to pollen grasses

    phase 2 small molecule active

    1 trial
  16. PRO-EV71/CA16-1001

    Sinovac Research and Development Co.,

    Hand, Foot and Mouth Disease

    phase 2 mab active

    1 trial
  17. PRO-RCT-GRAM-2025-01

    Lacuna Pharma Pty Ltd

    Allergic rhinoconjunctivitis caused due to exposure to pollen grasses

    phase 2 small molecule active

    1 trial
  18. PRO-nCOV-1002

    Sinovac Research and Development Co.,

    COVID-19

    phase 2 mab completed

    2 trials
  19. PRO-nCOV-1003

    Sinovac Research and Development Co.,

    COVID-19

    phase 2 mab completed

    1 trial
  20. PRO-nCOV-2002

    Sinovac Research and Development Co.,

    COVID-19

    phase 2 mab on hold

    1 trial
  21. PRO-nCOV-2004

    Sinovac Research and Development Co.,

    COVID-19

    phase 2 mab terminated

    1 trial
  22. PRO-nCOV-2009

    Sinovac Research and Development Co.,

    COVID-19

    phase 2 mab completed

    1 trial
  23. PRO044 SC

    BioMarin Pharmaceutical Australia Pty Ltd

    Duchenne Muscular Dystrophy

    phase 2 small molecule completed

    1 trial
  24. PRO044 SC 6 mg/kg

    BioMarin Pharmaceutical Australia Pty Ltd

    Duchenne Muscular Dystrophy

    phase 2 small molecule terminated

    1 trial
  25. PRO045, 0.15 mg/kg/week

    BioMarin Pharmaceutical Australia Pty Ltd

    Duchenne Muscular Dystrophy

    phase 2 small molecule terminated

    1 trial
  26. PRODIGE 104 A

    CERO THERAPEUTICS HOLDINGS, INC.

    Resectable borderline pancreatic adenocarcinoma

    phase 2 small molecule active

    1 trial
  27. PRODIGE 107-ENGIC01-COLOSOTO

    NORTHWEST BIOTHERAPEUTICS INC

    Colorectal Carcinoma

    phase 2 small molecule active

    1 trial
  28. PRODIGE 111

    CERO THERAPEUTICS HOLDINGS, INC.

    stomach cancer, Esophage, gastro-oesophageal junction adenocarcinoma

    phase 2 small molecule active

    1 trial
  29. PRODIGE 34 - ADAGE

    CERO THERAPEUTICS HOLDINGS, INC.

    colon cancer

    phase 2 small molecule active

    1 trial
  30. PROICM 2019-03 MES

    The George Institute

    Malignant Peritoneal Mesothelioma

    phase 2 other active

    1 trial
  31. PROICM 2020-04 GAB

    The George Institute

    local advenced pancreatic adenocarcinoma

    phase 2 small molecule active

    1 trial
  32. PROICM 2021-02 GAB

    The George Institute

    Metastatic pancreatic adenocarcinoma

    phase 2 other active

    1 trial
  33. PROICM 2021-04 REL

    The George Institute

    Neuroendocrine tumor

    phase 2 small molecule active

    1 trial
  34. PRT3789

    Prelude Therapeutics Inc

    Advanced Solid Tumor

    phase 2 small molecule completed

    2 trials
  35. PRT3789-02

    Prelude Therapeutics Inc

    non-small cell lung cancer (NSCLC), Esophageal Cancer, Advanced or Metastatic Solid Tumors with a SMARCA4 Mutation

    phase 2 small molecule active

    1 trial
  36. PRX-100

    LENZ Therapeutics

    Presbyopia

    phase 2 small molecule completed

    1 trial
  37. PRX-112

    Protalix BioTherapeutics

    Gaucher Disease

    phase 2 small molecule completed

    2 trials
  38. PRX-115

    Protalix BioTherapeutics

    Gout

    phase 2 mab active

    2 trials
  39. PS22PET

    AXIM BIOTECHNOLOGIES, INC.

    (suspision on) Neuroblastoma

    phase 2 small molecule active

    1 trial
  40. PS433540

    LIGAND PHARMACEUTICALS INC

    Hypertension

    phase 2 small molecule completed

    1 trial
  41. PSMA PET/MR - Gallium-68 labeled PSMA-HBED-CC

    Telix Innovations

    Prostate Cancer

    phase 2 small molecule active

    1 trial
  42. PSt012021

    Lacuna Pharma Pty Ltd

    Myopia progression in children

    phase 2 small molecule active

    1 trial
  43. PT150

    United Therapeutics Europe Ltd

    PTSD - Post Traumatic Stress Disorder

    phase 2 small molecule active

    1 trial
  44. PTC124

    PTC THERAPEUTICS, INC.

    Duchenne Muscular Dystrophy

    phase 2 small molecule completed

    1 trial
  45. PTC124

    PTC THERAPEUTICS, INC.

    Cystic Fibrosis

    phase 2 small molecule completed

    2 trials
  46. PTC299

    PTC THERAPEUTICS, INC.

    Neurofibromatosis 2

    phase 2 small molecule terminated

    1 trial
  47. PTC518

    PTC THERAPEUTICS, INC.

    Huntington Disease

    phase 2 small molecule completed

    1 trial
  48. PTC518-CNS-002-HD

    PTC THERAPEUTICS, INC.

    Huntington’s Disease

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.