Friday, July 10, 2026
🇺🇸 FDA

Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 1 of 99

  1. (+)-SJ000557733

    CNS Pharmaceuticals

    Plasmodium Falciparum Malaria

    phase 1 small molecule completed

    1 trial

  2. 000414

    Ferring Pharmaceuticals

    Inflammatory Gastrointestinal Disease

    phase 1 other active

    1 trial

  3. 000426

    Ferring Pharmaceuticals

    Infertility in women undergoing assisted reproductive technologies (ART)

    phase 1 other active

    1 trial

  4. 000427

    Ferring Pharmaceuticals

    Infertility in women undergoing assisted reproductive technologies (ART)

    phase 1 other active

    1 trial

  5. 01-AMO-CLA-BIO-25

    Zaklady FarmaFarmaceutyczne Polpharma S.Aceutyczne Polpharma S.A.

    infections

    phase 1 other active

    1 trial

  6. 01-DAP-BIO-24

    Zaklady FarmaFarmaceutyczne Polpharma S.Aceutyczne Polpharma S.A.

    intended for treatment of for the treatment of (2): • insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise. • symptomatic chronic heart failure. • chronic kidney disease.

    phase 1 other active

    1 trial

  7. 01/2023/Pozlab

    s.r.o.

    increased blood clotting

    phase 1 other active

    1 trial

  8. 01API2024

    Lacuna Pharma Pty Ltd

    Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA); age≥ 75 years; hypertension; diabetes mellitus; symptomatic heart failure (NYHA Class ≥ II). Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults.

    phase 1 other active

    1 trial

  9. 01INDA2024

    Lacuna Pharma Pty Ltd

    Maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD)

    phase 1 other active

    1 trial

  10. 02API2024

    Lacuna Pharma Pty Ltd

    Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA); age≥ 75 years; hypertension; diabetes mellitus; symptomatic heart failure (NYHA Class ≥ II). Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults.

    phase 1 other active

    1 trial

  11. 0352-2189

    Boehringer Ingelheim

    1. Patients with compensated liver cirrhosis due to any underlying liver disease with advanced fibrosis (F4) and hepatic impairment that meets the criteria for Child-Pugh A 2. Patients with decompensated liver cirrhosis due to any underlying liver disease with advanced fibrosis (F4) and hepatic impairment that meets the criteria for Child-Pugh B

    phase 1 other active

    1 trial

  12. 0352-2190

    Boehringer Ingelheim

    1. Patients with compensated liver cirrhosis due to any underlying liver disease with advanced fibrosis (F4) and hepatic impairment that meets the criteria for Child-Pugh A 2. Patients with decompensated liver cirrhosis due to any underlying liver disease with advanced fibrosis (F4) and hepatic impairment that meets the criteria for Child-Pugh B

    phase 1 other active

    1 trial

  13. 039(C/a)MD23341

    Lacuna Pharma Pty Ltd

    Intended indication: Major Depressive Disorders with and without anxiety, Healthy volunteers, therapeutic indication not studied

    phase 1 other active

    1 trial

  14. 0439-24

    Lacuna Pharma Pty Ltd

    Melanoma

    phase 1 other active

    1 trial

  15. 091

    United Therapeutics Europe Ltd

    HIV Infections

    phase 1 mab completed

    1 trial

  16. 1 Nalmefene implant

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Abuse and Addiction

    phase 1 small molecule active

    1 trial

  17. 1 mg/kg GR-MD-02

    GALECTIN THERAPEUTICS INC

    Metastatic Melanoma

    phase 1 mab completed

    1 trial

  18. 1% icotinib hydrochloride cream

    Betta Pharmaceuticals Co.,

    Psoriasis

    phase 1 small molecule completed

    1 trial

  19. 10-223-00277-01

    BRIGHT MINDS BIOSCIENCES INC.

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  20. 100 mg Delamanid

    Otsuka Beijing Research Institute

    Multidrug Resistant Tuberculosis

    phase 1 small molecule completed

    1 trial

  21. 100 mg GLPG1205

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  22. 100 mg Resmetirom Tablet

    Madrigal Pharmaceuticals EU Limited

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  23. 100 mg dose of [14C] GLPG0634

    Lakefront Biotherapeutics NV

    Healthy

    phase 1 small molecule completed

    1 trial

  24. 100U inactivated Enterovirus Type 71 Vaccine

    Sinovac Research and Development Co.,

    Hand-foot-mouth Disease

    phase 1 mab completed

    1 trial

  25. 1019/25

    Laboratorios Tillomed Spain S.L.U

    Bioavailability study in healthy volunteers under fed conditions.

    phase 1 other active

    1 trial

  26. 1028/25

    Lacuna Pharma Pty Ltd

    Not applicable (submitted trial is a BE study in healthy subjects).

    phase 1 other active

    1 trial

  27. 1046/25

    Lacuna Pharma Pty Ltd

    Not applicable (submitted trial is a BE study in healthy subjects.

    phase 1 other active

    1 trial

  28. 1048/25

    Lacuna Pharma Pty Ltd

    Not applicable (submitted trial is a BE study in healthy subjects).

    phase 1 other active

    1 trial

  29. 1053/25

    Lacuna Pharma Pty Ltd

    Bioequivalence study under fasting conditions

    phase 1 other active

    1 trial

  30. 1062/25

    Laboratorios Tillomed Spain S.L.U

    Bioavailability study in healthy volunteers under fasting conditions.

    phase 1 other active

    1 trial

  31. 11-valent recombinant human papilloma virus vaccine (Hansenula polymorpha)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    HPV Infection

    phase 1 mab completed

    1 trial

  32. 11C-OMAR

    BRIGHT MINDS BIOSCIENCES INC.

    Cannabis Use Disorder

    phase 1 small molecule completed

    1 trial

  33. 1230.15

    Boehringer Ingelheim

    Neoplasms

    phase 1 small molecule completed

    1 trial

  34. 1245-0358

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  35. 124I-labeled monoclonal antibody Mu 11-1F4

    BRIGHT MINDS BIOSCIENCES INC.

    AL Amyloidosis

    phase 1 mab completed

    1 trial

  36. 1305-0037

    Boehringer Ingelheim

    Pharmacokinetic trial

    phase 1 other active

    1 trial

  37. 1305-0039

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  38. 1305-0051

    Boehringer Ingelheim

    Pharmacokinetic trial

    phase 1 other active

    1 trial

  39. 1305-0113

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  40. 1305-0119

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  41. 131I-IPA

    Telix Innovations

    Neoplastic Disease

    phase 1 small molecule active

    1 trial

  42. 131I-TLX-101-002

    Lacuna Pharma Pty Ltd

    Glioblastoma multiforme (GBM)

    phase 1 other active

    1 trial

  43. 131I-apamistmab

    Actinium Pharmaceuticals

    Sickling Disorder Due to Hemoglobin S

    phase 1 small molecule active

    1 trial

  44. 1366-0042

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  45. 1368-0151

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  46. 1378-0024

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  47. 1378-0025

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  48. 1378-0043

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.