Metabolic & obesity · Phase II

Top sponsors

• Takeda 13 programs
• IONIS PHARMACEUTICALS 10 programs
• Oramed Pharmaceuticals 10 programs
• Regeneron UK 10 programs
• United Therapeutics Europe 7 programs
• Anaxis Pharma 6 programs
• NovoThirteen 6 programs
• Vertex Pharmaceuticals (Australia) 6 programs
• vTv Therapeutics 6 programs
• Alnylam Netherlands 5 programs
• LEXICON PHARMACEUTICALS 5 programs
• Rhythm Pharmaceuticals Netherlands 5 programs

1. 0.59 mg fluocinolone acetonide intravitreal implant

   Bausch & Lomb Incorporated

   Diabetic Macular Edema

   phase 2 · small molecule · completed

   1 trial →

2. 10mg DS-8500a tablet

   Daiichi Sankyo

   Type 2 Diabetes Mellitus

   phase 2 · small molecule · completed

   1 trial →

3. 1485-0018

   Boehringer Ingelheim

   Centre-involved diabetic macular edema

   phase 2 · small molecule · active

   1 trial →

4. 21839

   Bayer AG

   Chronic kidney disease in type 2 diabetes mellitus

   phase 2 · small molecule · active

   1 trial →

5. 2HPβCD

   ZyVersa Therapeutics

   Diabetic Kidney Disease

   phase 2 · small molecule · terminated

   1 trial →

6. 3-V Bioscience-2640

   Sagimet Biosciences

   Metabolic Syndrome

   phase 2 · small molecule · completed

   1 trial →

7. 3133004

   Orion Laboratories Pty.

   CHRONIC PAIN DUE TO DIABETIC PERIPHERAL NEUROPATHY

   phase 2 · small molecule · active

   1 trial →

8. 4D-150 IVT

   4D Molecular Therapeutics

   Diabetic Macular Edema

   phase 2 · mab · active

   1 trial →

9. 5% Bisphosphocin Topical Gel

   Lakewood-Amedex Biotherapeutics

   Chronic Diabetic Foot Ulcers

   phase 2 · small molecule · terminated

   1 trial →

10. 5% Nu-3 gel

    Lakewood-Amedex Biotherapeutics

    Diabetic Foot Infection

    phase 2 · small molecule · active

    1 trial →

11. 75 mg LX4211

    LEXICON PHARMACEUTICALS, INC.

    Type 2 Diabetes Mellitus

    phase 2 · small molecule · completed

    1 trial →

12. ALG-055009

    Aligos Therapeutics

    NASH

    phase 2 · small molecule · completed

    1 trial →

13. ALN-2232

    Alnylam Netherlands B.V.

    Obesity

    phase 2 · small molecule · active

    1 trial →

14. ALN-4324

    Alnylam Netherlands B.V.

    Obese or Overweight Healthy Volunteers

    phase 2 · small molecule · active

    1 trial →

15. ALN-4324

    Alnylam Netherlands B.V.

    Type 2 Diabetes Mellitus (T2DM)

    phase 2 · small molecule · active

    1 trial →

16. ALN-ANG3

    Regeneron UK Limited

    Diabetic Kidney Disease (DKD)

    phase 2 · small molecule · active

    1 trial →

17. ALN-CIDEB

    Regeneron UK Limited

    Metabolic Dysfunction-Associated Steatotic Liver Disease

    phase 2 · small molecule · active

    1 trial →

18. ALN-HSD

    Regeneron UK Limited

    Metabolic Dysfunction-Associated SteatoHepatitis (MASH)

    phase 2 · small molecule · active

    1 trial →

19. ALN-KHK

    Alnylam Netherlands B.V.

    Type 2 Diabetes Mellitus (T2DM)

    phase 2 · small molecule · terminated

    1 trial →

20. ALN-PNP

    Regeneron UK Limited

    Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

    phase 2 · small molecule · active

    1 trial →

21. AMG 133, Placebo for AMG 133

    Amgen

    Overweight and Obesity

    phase 2 · small molecule · active

    1 trial →

22. ANN-008

    Lacuna Pharma Pty Ltd

    Diabetic Retinopathy, Retinal Vein Occlusion

    phase 2 · other · active

    1 trial →

23. ARD-101

    Ark Therapeutics

    Obesity

    phase 2 · small molecule · completed

    1 trial →

24. ARO-ALK7

    Arrowhead Pharmaceuticals Ireland Limited

    Obesity

    phase 2 · small molecule · active

    1 trial →

25. ARO-INHBE

    Arrowhead Pharmaceuticals Ireland Limited

    Obesity

    phase 2 · small molecule · active

    1 trial →

26. ASC30 tablets

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    T2DM (Type 2 Diabetes Mellitus)

    phase 2 · small molecule · active

    1 trial →

27. AT-1501

    Eledon Pharmaceuticals

    Type 1 Diabetes Mellitus

    phase 2 · small molecule · terminated

    1 trial →

28. AT-1501 IV Infusion

    Eledon Pharmaceuticals

    Brittle Type 1 Diabetes Mellitus

    phase 2 · mab · terminated

    1 trial →

29. Aflibercept

    Regeneron UK Limited

    Proliferative Diabetic Retinopathy

    phase 2 · small molecule · completed

    1 trial →

30. Aldesleukin

    United Therapeutics Europe Ltd

    Type 1 Diabetes

    phase 2 · small molecule · completed

    1 trial →

31. Aleniglipron

    Structure Therapeutics

    Obese

    phase 2 · small molecule · active

    1 trial →

32. Aleniglipron or Placebo

    Structure Therapeutics

    Obesity, Overweight, or Chronic Weight Management

    phase 2 · small molecule · active

    2 trials →

33. Antimicrobial agent

    Lakewood-Amedex Biotherapeutics

    Diabetic Foot Ulcers (DFUs)

    phase 2 · small molecule · active

    1 trial →

34. BC45538

    Hoffmann-La Roche

    Obesity

    phase 2 · small molecule · active

    1 trial →

35. BI 456906

    Boehringer Ingelheim

    Diabetes Mellitus, Type 2

    phase 2 · small molecule · completed

    1 trial →

36. BI 764524, Sham Injection Procedure

    Boehringer Ingelheim

    Diabetic retinopathy

    phase 2 · small molecule · active

    1 trial →

37. BP45703

    Hoffmann-La Roche

    Type 2 Diabetes Mellitus (T2D)

    phase 2 · small molecule · active

    1 trial →

38. Bempedoic acid + Ezetimibe FDC Oral Tablet

    Esperion Therapeutics

    Diabetes

    phase 2 · small molecule · completed

    1 trial →

39. Bicifadine

    XTL BIOPHARMACEUTICALS LTD

    Diabetic Peripheral Neuropathy

    phase 2 · small molecule · active

    1 trial →

40. Bicifadine

    XTL BIOPHARMACEUTICALS LTD

    Chronic Peripheral Neuropathy Pain in Diabetics

    phase 2 · small molecule · terminated

    1 trial →

41. Bisphosphocin Nu-3

    Lakewood-Amedex Biotherapeutics

    Diabetic Foot Infections

    phase 2 · small molecule · completed

    1 trial →

42. Bivamelagon

    Rhythm Pharmaceuticals Netherlands B.V.

    Hypothalamic Obesity

    phase 2 · small molecule · active

    1 trial →

43. C5541010

    Pfizer Australia Pty Ltd

    Obesity, Overweight

    phase 2 · small molecule · active

    1 trial →

44. CF102

    Can-Fite BioPharma

    Non-alcoholic Steatohepatitis (NASH)

    phase 2 · small molecule · completed

    1 trial →

45. CLBS03 Low Dose

    LISATA THERAPEUTICS, INC.

    Diabetes Mellitus

    phase 2 · mab · completed

    1 trial →

46. CRV431 75mg

    Hepion Pharmaceuticals

    NASH - Nonalcoholic Steatohepatitis

    phase 2 · small molecule · completed

    1 trial →

47. CS-3150

    Daiichi Sankyo

    Diabetic Nephropathy

    phase 2 · small molecule · completed

    1 trial →

48. CX11202

    Lacuna Pharma Pty Ltd

    Type 2 Diabetes Mellitus

    phase 2 · small molecule · active

    1 trial →

Frequently asked questions