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Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

Page 68 of 151

  1. IO102-IO103 in combination with pembrolizumab

    IO Biotech

    Lung Cancer Non Small Cell

    phase 2 small molecule completed

    1 trial

  2. IOB-022/KN-D38

    IO Biotech

    Metastatic Squamous Cell Carcinoma of Head and Neck (SCCHN), Metastatic Urothelial Bladder Cancer (mUBC), Metastatic Non-Small Cell Lung Cancer (NSCLC)

    phase 2 small molecule active

    1 trial

  3. IOBENGUANE (123I) , 68Ga-SSO120

    AXIM BIOTECHNOLOGIES, INC.

    neuroblastoma

    phase 2 small molecule active

    1 trial

  4. ION-682884

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 2 small molecule completed

    1 trial

  5. ION-827359

    IONIS PHARMACEUTICALS INC

    Chronic Bronchitis

    phase 2 small molecule terminated

    1 trial

  6. ION224

    IONIS PHARMACEUTICALS INC

    Steatohepatitis, Nonalcoholic

    phase 2 small molecule completed

    1 trial

  7. ION337

    IONIS PHARMACEUTICALS INC

    Dravet Syndrome

    phase 2 small molecule active

    1 trial

  8. ION373-CS1

    IONIS PHARMACEUTICALS INC

    Alexander Disease

    phase 2 small molecule active

    1 trial

  9. ION440

    IONIS PHARMACEUTICALS INC

    Methyl CpG binding protein 2 (MECP2) Duplication Syndrome (MDS)

    phase 2 small molecule active

    1 trial

  10. ION440

    IONIS PHARMACEUTICALS INC

    Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome

    phase 2 small molecule active

    1 trial

  11. ION582

    IONIS PHARMACEUTICALS INC

    Angelman syndrome

    phase 2 small molecule active

    1 trial

  12. ION717

    IONIS PHARMACEUTICALS INC

    Prion Disease

    phase 2 small molecule active

    1 trial

  13. ION775

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 2 small molecule active

    1 trial

  14. ION904

    IONIS PHARMACEUTICALS INC

    Hypertension

    phase 2 small molecule completed

    1 trial

  15. IONIS DGAT2Rx

    IONIS PHARMACEUTICALS INC

    Hepatic Steatosis

    phase 2 small molecule completed

    1 trial

  16. IONIS GHR-LRx

    IONIS PHARMACEUTICALS INC

    Acromegaly

    phase 2 small molecule completed

    2 trials

  17. IONIS-AGT-LRx

    IONIS PHARMACEUTICALS INC

    Chronic Heart Failure With Reduced Ejection Fraction

    phase 2 small molecule completed

    1 trial

  18. IONIS-DMPKRx

    IONIS PHARMACEUTICALS INC

    Myotonic Dystrophy Type 1

    phase 2 small molecule completed

    1 trial

  19. IONIS-FB-LRx

    IONIS PHARMACEUTICALS INC

    Primary IgA Nephropathy

    phase 2 small molecule completed

    1 trial

  20. IONIS-FB-LRx

    IONIS PHARMACEUTICALS INC

    Macular Degeneration

    phase 2 small molecule completed

    1 trial

  21. IONIS-FB-Lrx

    IONIS PHARMACEUTICALS INC

    Geographic Atrophy

    phase 2 small molecule terminated

    1 trial

  22. IONIS-HBVRx

    IONIS PHARMACEUTICALS INC

    Hepatitis B

    phase 2 small molecule completed

    1 trial

  23. IONIS-PKKRx (ISIS 546254)

    IONIS PHARMACEUTICALS INC

    Chronic Migraine

    phase 2 small molecule completed

    1 trial

  24. IONIS-STAT3Rx

    IONIS PHARMACEUTICALS INC

    Advanced Cancers

    phase 2 small molecule completed

    1 trial

  25. IOR-IISML42037

    The George Institute

    Lung Cancer

    phase 2 small molecule active

    1 trial

  26. IOR-REG-2501

    The George Institute

    Cutaneous Basal Cell Carcinoma

    phase 2 small molecule active

    1 trial

  27. IOV-3001

    Iovance Biotherapeutics B.V.

    Unresectable Melanoma

    phase 2 mab active

    1 trial

  28. IOV-4001

    Iovance Biotherapeutics B.V.

    Unresectable Melanoma

    phase 2 mab active

    1 trial

  29. IOV-COM-202

    Iovance Biotherapeutics B.V.

    Neoplasm

    phase 2 small molecule active

    1 trial

  30. IOV-LUN-202

    Iovance Biotherapeutics B.V.

    Metastatic Non-Small-Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  31. IOV-MEL-202

    Iovance Biotherapeutics B.V.

    Previously treated advanced melanoma

    phase 2 small molecule active

    1 trial

  32. IPC 2022-067

    The George Institute

    acute myeloid leukemia

    phase 2 small molecule active

    1 trial

  33. IPC 2024-001

    The George Institute

    acute myeloid leukemia

    phase 2 small molecule active

    1 trial

  34. IPH5201-201

    Lacuna Pharma Pty Ltd

    Non-Small Cell Lung Cancer II, III

    phase 2 small molecule active

    1 trial

  35. IPH6501

    Lacuna Pharma Pty Ltd

    Relapsed and/or Refractory CD20-expressing Non-Hodgkin Lymphoma

    phase 2 small molecule active

    1 trial

  36. IPILIMUMAB for metastasized melonama uveal

    Disc Medicine

    metastasized melonama uveal

    phase 2 small molecule active

    1 trial

  37. IPILIMUMAB, NIVOLUMAB

    Ningbo Cancer Hospital

    type B3 thymoma and thymic carcinoma

    phase 2 small molecule active

    1 trial

  38. IPN01195, IPN01195

    Ipsen

    Advanced Solid Tumour

    phase 2 small molecule active

    1 trial

  39. IPN01203

    Ipsen

    Advanced Solid Tumor, Metastatic Solid Tumor

    phase 2 small molecule active

    1 trial

  40. IPN10200

    Ipsen

    Episodic Migraine

    phase 2 mab active

    1 trial

  41. IPN10200, IPN10200 placebo

    Ipsen

    Episodic Migraine Chronic Migraine

    phase 2 small molecule active

    1 trial

  42. IPN60300

    Ipsen

    Advanced or metastatic solid tumours

    phase 2 small molecule active

    1 trial

  43. IPSTYL for advanced progressive gastro-int…

    Fondazione Telethon ETS

    advanced progressive gastro-intestinal or lung carcinoids

    phase 2 small molecule active

    1 trial

  44. IPV26

    Sanofi Pasteur

    Poliomyelitis

    phase 2 mab completed

    1 trial

  45. IR Viloxazine

    SUPERNUS PHARMACEUTICALS, INC.

    Attention-Deficit/Hyperactivity Disorder (ADHD)

    phase 2 small molecule completed

    1 trial

  46. IR-TPM (Topamax)

    SUPERNUS PHARMACEUTICALS, INC.

    Migraine

    phase 2 small molecule terminated

    1 trial

  47. IRINOTECAN, lurbinectedin

    Lacuna Pharma Pty Ltd

    Selected Advanced Solid Tumors

    phase 2 small molecule active

    1 trial

  48. IRSP-PSI-2024-171

    The George Institute

    Major depressive disorder

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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