Friday, July 10, 2026

Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

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  1. ondansetron

    The First People's Hospital of Lianyungang

    Hepatocellular Carcinoma (HCC)

    phase 2 small molecule active

    1 trial
  2. online adaptive radiotherapy

    The First People's Hospital of Lianyungang

    Cervical Cancer

    phase 2 other active

    1 trial
  3. open discectomy

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Lumbar Disc Herniation

    phase 2 other active

    1 trial
  4. opiates

    BRIGHT MINDS BIOSCIENCES INC.

    Heroin Dependence

    phase 2 small molecule completed

    1 trial
  5. oral treprostinil

    United Therapeutics Europe Ltd

    PAH

    phase 2 small molecule completed

    1 trial
  6. orelabrutinib combined with rituximab regimen

    The First People's Hospital of Lianyungang

    Marginal Zone Lymphoma(MZL)

    phase 2 small molecule active

    1 trial
  7. oritavancin

    Targanta Netherlands B.V.

    Staphylococcal Skin Infections

    phase 2 small molecule completed

    1 trial
  8. osimertinib

    AstraZeneca

    Carcinoma

    phase 2 small molecule active

    1 trial
  9. osimertinib mesylate tablets and anlotinib hydrochloride capsules

    The First People's Hospital of Lianyungang

    Non Small Cell Lung Cancer

    phase 2 small molecule terminated

    1 trial
  10. oxaliplatin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Stomach Neoplasms

    phase 2 small molecule active

    1 trial
  11. oxycodone 15 mg

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid-Related Disorders

    phase 2 small molecule completed

    1 trial
  12. p.DOM-WT1-37 DNA Vaccine and p.DOM-WT1-126 DNA Vaccine

    INOVIO PHARMACEUTICALS, INC.

    Leukaemia (Acute)

    phase 2 mab completed

    1 trial
  13. pCAR-19B cells

    Chongqing Precision Biotech Co., Ltd

    Acute Lymphoblastic Leukemia

    phase 2 mab active

    2 trials
  14. pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine

    United Therapeutics Europe Ltd

    Anatomic Stage I Breast Cancer AJCC v8

    phase 2 mab active

    1 trial
  15. paclitaxel/carboplatin/lapatinib

    Hospital Authority, Hong Kong

    ErbB2-Positive Stage I-III Breast Cancer

    phase 2 small molecule active

    1 trial
  16. palifosfamide

    Alaunos Therapeutics

    Adult Central Nervous System Germ Cell Tumor

    phase 2 small molecule terminated

    1 trial
  17. pallidotomy

    Ultragenyx UK Limited

    Parkinson Disease

    phase 2 other completed

    1 trial
  18. pandemic influenza vaccine (H5N1 strain NIBRG-14)

    Sinovac Research and Development Co.,

    Pandemic Influenza

    phase 2 mab completed

    1 trial
  19. pazopanib (GW786034)

    GlaxoSmithKline

    Neoplasms, Uterine Cervix

    phase 2 small molecule completed

    1 trial
  20. pazopanib (GW786034) 400 mg

    GlaxoSmithKline

    Neoplasms, Breast

    phase 2 small molecule completed

    1 trial
  21. pectin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Crohn's Disease

    phase 2 small molecule terminated

    1 trial
  22. pegcrisantaspase

    Jazz Pharmaceuticals Ireland Limited

    Acute Lymphoblastic Leukemia

    phase 2 small molecule terminated

    1 trial
  23. peginesatide

    Takeda

    Anemia

    phase 2 small molecule completed

    5 trials
  24. pembrolizumab

    Hospital Authority, Hong Kong

    Locally Recurrent Cancer

    phase 2 small molecule active

    1 trial
  25. pembrolizumab

    The University of Hong Kong

    T-Cell Lymphoma

    phase 2 small molecule active

    1 trial
  26. pembrolizumab

    The First People's Hospital of Lianyungang

    Advanced Non-squamous Non-small-cell Lung Cancer

    phase 2 small molecule active

    1 trial
  27. pemetrexed

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Brain Metastases

    phase 2 small molecule active

    1 trial
  28. pemetrexed

    United Therapeutics Europe Ltd

    Lung Cancer

    phase 2 small molecule completed

    1 trial
  29. pepinemab + pembrolizumab

    VACCINEX, INC.

    Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC)

    phase 2 small molecule completed

    1 trial
  30. perindopril arginine

    United Therapeutics Europe Ltd

    Abdominal Aortic Aneurysm

    phase 2 small molecule completed

    1 trial
  31. pharmorubicin or pirarubicin

    The First People's Hospital of Lianyungang

    Upper Tract Urothelial Carcinoma

    phase 2 small molecule active

    1 trial
  32. phosphate buffered saline., FX06

    Lacuna Pharma Pty Ltd

    Acute Respiratory Distress Syndrome (ARDS)

    phase 2 small molecule active

    1 trial
  33. phosphate-buffered saline for SC administration

    Alnylam Netherlands B.V.

    Hereditary Hemorrhagic Telangiectasia (HHT)

    phase 2 small molecule active

    1 trial
  34. pimozide

    Ultragenyx UK Limited

    Tourette Syndrome

    phase 2 small molecule completed

    1 trial
  35. pioglitazone

    Takeda

    Alzheimer Disease

    phase 2 small molecule completed

    1 trial
  36. pioglitazone

    Takeda

    Asthma

    phase 2 small molecule completed

    1 trial
  37. placebo

    Nektar Therapeutics UK Limited

    Opioid Induced Constipation (OIC)

    phase 2 small molecule completed

    1 trial
  38. placebo

    Universal Integrated

    Postprandial Distress Syndrome

    phase 2 small molecule active

    1 trial
  39. placebo

    The First People's Hospital of Lianyungang

    COVID-19 Thalidomide

    phase 2 small molecule active

    1 trial
  40. placebo mouthwash

    BRIGHT MINDS BIOSCIENCES INC.

    Dentinal Hypersensitivity

    phase 2 other completed

    1 trial
  41. placebo of BAY 3427080, BAY 3427080

    Bayer AG

    Sleep disturbances associated with menopause

    phase 2 small molecule active

    1 trial
  42. pneumococcal polysaccharide and protein conjugate vaccines

    United Therapeutics Europe Ltd

    Pneumococcal Infections

    phase 2 mab completed

    1 trial
  43. ponatinib - Phase 1

    Takeda

    Chronic Myeloid Leukemia (CML)

    phase 2 small molecule completed

    1 trial
  44. pregabalin

    United Therapeutics Europe Ltd

    Pain

    phase 2 small molecule completed

    1 trial
  45. pyrotinib and trastuzumab in combinition with neoadjuvant chemotherapy

    The First People's Hospital of Lianyungang

    HER2-positive Breast Cancer

    phase 2 small molecule active

    1 trial
  46. rAAV9.CMV.hNAGLU

    ABEONA THERAPEUTICS INC.

    Mucopolysaccharidosis Type 3 B

    phase 2 mab terminated

    1 trial
  47. rAvPAL-PEG

    BioMarin Pharmaceutical Australia Pty Ltd

    Phenylketonuria

    phase 2 small molecule completed

    3 trials
  48. rAvPAL-PEG 0.001 mg/kg

    BioMarin Pharmaceutical Australia Pty Ltd

    Phenylketonuria

    phase 2 small molecule completed

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.