Friday, July 10, 2026
🇺🇸 FDA

Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

Page 140 of 151

  1. ZW25 (Zanidatamab)

    BEONE MEDICINES AUS PTY LTD

    HER2-amplified Biliary Tract Cancers

    phase 2 small molecule completed

    1 trial

  2. ZW25 (Zanidatamab)

    Jazz Pharmaceuticals Ireland Limited

    HER2+/HR+ Breast Cancer

    phase 2 small molecule completed

    1 trial

  3. ZW25 (Zanidatamab)

    Jazz Pharmaceuticals Ireland Limited

    HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer

    phase 2 small molecule completed

    1 trial

  4. ZWI-ZW25-202

    Jazz Pharmaceuticals Ireland Limited

    Breast cancer patients including those with locally advanced (unresectable) or metastatic HER2-positive, HR-positive breast cancer

    phase 2 small molecule active

    1 trial

  5. ZYN002

    Harmony Biosciences Holdings

    22Q11.2 Deletion Syndrome

    phase 2 small molecule completed

    1 trial

  6. ZZ-IT-ICI-HCC 1line-023

    Second Affiliated Hospital of Soochow University

    Liver Cancer

    phase 2 small molecule active

    1 trial

  7. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    HER2-positive Breast Cancer

    phase 2 small molecule active

    1 trial

  8. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    Breast Cancer

    phase 2 small molecule active

    1 trial

  9. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    Non-Small Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  10. Zanidatamab

    ALX ONCOLOGY HOLDINGS INC

    HER2-expressing Cancers

    phase 2 small molecule completed

    1 trial

  11. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    Gastroesophageal Adenocarcinoma

    phase 2 small molecule active

    1 trial

  12. Zanubrutinib

    The First People's Hospital of Lianyungang

    Non Hodgkin Lymphoma

    phase 2 small molecule active

    1 trial

  13. Zanubrutinib

    The First People's Hospital of Lianyungang

    Chronic Lymphocytic Leukemia

    phase 2 small molecule active

    1 trial

  14. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Refractory/Relapsed Autoimmune Hemolytic Anemia

    phase 2 small molecule active

    1 trial

  15. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Relapsed/Refractory Follicular Non-Hodgkin Lymphoma

    phase 2 small molecule completed

    1 trial

  16. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Mantle Cell Lymphoma

    phase 2 small molecule active

    1 trial

  17. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Mature B-cell Malignancies

    phase 2 small molecule completed

    1 trial

  18. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Mantle Cell Lymphoma

    phase 2 small molecule active

    1 trial

  19. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Immune Thrombocytopenia

    phase 2 small molecule active

    1 trial

  20. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Follicular Lymphoma

    phase 2 small molecule active

    1 trial

  21. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Diffuse Large B-cell Lymphoma (DLBCL)

    phase 2 small molecule active

    1 trial

  22. Zanubrutinib

    Wuhan Createrna Science and Technology Co., Ltd

    Cold agglutinin disease

    phase 2 small molecule active

    1 trial

  23. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

    phase 2 small molecule completed

    1 trial

  24. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Chronic Lymphocytic Leukemia (CLL)

    phase 2 small molecule active

    1 trial

  25. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Relapsed Diffuse Large B-cell Lymphoma

    phase 2 small molecule completed

    1 trial

  26. Zanubrutinib+Rituximab+Lenalidomide

    The First People's Hospital of Lianyungang

    Diffuse Large B Cell Lymphoma

    phase 2 small molecule active

    1 trial

  27. Zasocitinib

    Takeda

    Crohn's Disease

    phase 2 small molecule active

    2 trials

  28. Zasocitinib

    Takeda

    Nonsegmental Vitiligo

    phase 2 small molecule active

    1 trial

  29. Zasocitinib (Dose A)

    Takeda

    Hidradenitis Suppurativa

    phase 2 small molecule active

    1 trial

  30. Zelboraf 240 mg film-coated tablets

    Ningbo Cancer Hospital

    Patients with metastatic or unresectable locally advanced malignancies harboring BRAF genomic alterations, the biological target of vemurafenib, and who are no more amenable to curative treatment

    phase 2 small molecule active

    1 trial

  31. Zelenectide Pevedotin, BT8009

    BICYCLE THERAPEUTICS

    Advanced or Metastatic Non-small Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  32. Zemplar (paricalcitol ) capsules

    Abbott Australasia Pty Ltd

    Diabetic Nephropathy

    phase 2 small molecule completed

    1 trial

  33. Zentalis

    Zentalis Pharmaceuticals

    Advanced Pancreatic Adenocarcinoma

    phase 2 small molecule active

    1 trial

  34. Ziftomenib

    Kura Oncology

    Advanced Malignant Neoplasm

    phase 2 small molecule active

    1 trial

  35. Ziftomenib, Ziftomenib

    Kura Oncology

    Relapsed and/or refractory Acute Myeloid Leukemia

    phase 2 small molecule active

    1 trial

  36. Zilebesiran

    Alnylam Netherlands B.V.

    Mild to Moderate Hypertension

    phase 2 small molecule completed

    1 trial

  37. Zilebesiran

    Alnylam Netherlands B.V.

    High Cardiovascular Risk

    phase 2 small molecule completed

    1 trial

  38. Zilovertamab vedotin

    Merck Sharp and Dohme

    Hematologic Malignancies or Solid Tumors in Pediatric and Young Adults

    phase 2 small molecule active

    1 trial

  39. Zilretta

    Pacira Ireland Limited

    Osteoarthritis of Hip

    phase 2 small molecule terminated

    1 trial

  40. Zimberelimab

    Arcus Biosciences

    Melanoma

    phase 2 small molecule active

    1 trial

  41. Zimberelimab

    Arcus Biosciences

    Hepatobiliary Cancer

    phase 2 small molecule active

    1 trial

  42. Zimberelimab

    Arcus Biosciences

    Pancreatic Ductal Adenocarcinoma

    phase 2 small molecule active

    1 trial

  43. Zimberelimab

    Arcus Biosciences

    Adenocarcinoma Stomach

    phase 2 small molecule terminated

    1 trial

  44. Zimberelimab (ZIM)

    Arcus Biosciences

    Lung Cancer

    phase 2 small molecule active

    1 trial

  45. Zirconium Zr 89 Girentuximab

    Telix Innovations

    Clear Cell Renal Cell Carcinoma

    phase 2 small molecule active

    1 trial

  46. Ziv-Aflibercept

    Regeneron UK Limited

    Uveal Melanoma

    phase 2 mab terminated

    1 trial

  47. Zn-Telomir

    Telomir Pharmaceuticals

    Triple-Negative Breast Cancer (TNBC)

    phase 2 small molecule active

    1 trial

  48. Zoladex

    The First People's Hospital of Lianyungang

    Prostate Cancer

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.