Friday, July 10, 2026

Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

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  1. XEN1101 10 mg

    Xenon Pharmaceuticals

    Major Depressive Disorder

    phase 2 small molecule completed

    1 trial
  2. XMDYYYXYK-04

    The First People's Hospital of Lianyungang

    Acute Myeloid Leukemia

    phase 2 small molecule active

    1 trial
  3. XMDYYYXYK-12

    The First People's Hospital of Lianyungang

    Hematological Malignancy

    phase 2 small molecule active

    1 trial
  4. XP19986 CR

    Indivior Pty Ltd

    GERD

    phase 2 small molecule completed

    1 trial
  5. XPF-001

    Xenon Pharmaceuticals

    Primary Erythromelalgia

    phase 2 small molecule completed

    1 trial
  6. XPF-001

    Xenon Pharmaceuticals

    Dental Pain

    phase 2 small molecule completed

    1 trial
  7. XPF-002

    Xenon Pharmaceuticals

    Postherpetic Neuralgia

    phase 2 small molecule completed

    1 trial
  8. XPF-002

    Xenon Pharmaceuticals

    Primary Erythromelalgia

    phase 2 small molecule completed

    1 trial
  9. XPF-005

    Xenon Pharmaceuticals

    Acne Vulgaris

    phase 2 small molecule completed

    1 trial
  10. XPF-008-201

    Xenon Pharmaceuticals

    Adult focal (partial onset) epilepsy

    phase 2 small molecule active

    1 trial
  11. XPORT-MF-044

    Karyopharm Therapeutics Inc

    moderate thrombocytopenia, JAK inhibitor-naïve myelofibrosis

    phase 2 small molecule active

    1 trial
  12. XPORT-MM-028

    Karyopharm Therapeutics Inc

    Penta-refractory multiple myeloma and triple-class refractory multiple myeloma

    phase 2 small molecule active

    1 trial
  13. XTX202

    Xilio Therapeutics

    Advanced Solid Tumor

    phase 2 small molecule completed

    1 trial
  14. XTX301

    Xilio Therapeutics

    Advanced Solid Tumor

    phase 2 small molecule active

    1 trial
  15. Xanthohumol

    NORTHWEST BIOTHERAPEUTICS INC

    Crohn Disease

    phase 2 small molecule active

    1 trial
  16. Xarelto 2.5 mg film-coated tablets

    Tour Hekla

    Chronic hemodialysis

    phase 2 small molecule active

    1 trial
  17. Xenpozyme (olipudase alfa,GZ402665)

    Sanofi Winthrop Industrie

    Niemann-Pick disease

    phase 2 small molecule active

    1 trial
  18. Xospata 40 mg film-coated tablets

    Wuhan Createrna Science and Technology Co., Ltd

    Acute myeloid leukaemia, Acute myeloid leukaemia

    phase 2 small molecule active

    1 trial
  19. Xospata 40 mg film-coated tablets

    Fondazione Telethon ETS

    newly diagnosed non-M3 FLT3-positive acute myeloid leukemia

    phase 2 small molecule active

    1 trial
  20. Xyrem (sodium oxybate) oral solution

    Jazz Pharmaceuticals Ireland Limited

    Fibromyalgia

    phase 2 small molecule completed

    1 trial
  21. YERVOY for castration-resistant prostate c…

    Disc Medicine

    castration-resistant prostate cancer

    phase 2 small molecule active

    1 trial
  22. YM150

    Astellas Pharma Inc

    Thromboembolism

    phase 2 small molecule completed

    1 trial
  23. YMSM

    BRIGHT MINDS BIOSCIENCES INC.

    Behavior

    phase 2 other completed

    1 trial
  24. YPEG-rhEPO

    The First People's Hospital of Lianyungang

    Renal Anemia of Chronic Kidney Disease

    phase 2 small molecule completed

    1 trial
  25. Yi Qi Yang Yin Decoction

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Primary Sjögren Syndrome

    phase 2 small molecule active

    1 trial
  26. Yigansan

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Tourette Disorder

    phase 2 small molecule completed

    1 trial
  27. Yogurt smoothie with BB-12

    United Therapeutics Europe Ltd

    Metabolic Syndrome

    phase 2 small molecule active

    1 trial
  28. Yougui granules

    The First People's Hospital of Lianyungang

    Renal Insufficiency, Chronic

    phase 2 small molecule terminated

    1 trial
  29. Z-Endoxifen

    ATOSSA THERAPEUTICS, INC.

    Breast Density

    phase 2 small molecule completed

    1 trial
  30. Z171100001017104

    Universal Integrated

    Anovulatory Infertility

    phase 2 small molecule active

    1 trial
  31. Z650

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Esophageal Squamous Cell Carcinoma

    phase 2 small molecule completed

    1 trial
  32. ZADAXIN® 1,6 mg/ml

    Lacuna Pharma Pty Ltd

    Cystic Fibrosis

    phase 2 small molecule active

    1 trial
  33. ZASOCITINIB

    Takeda

    Moderate to Severely Active Ulcerative Colitis & Moderate to Severely Active Crohn's Disease

    phase 2 small molecule active

    1 trial
  34. ZASOCITINIB, Matching Placebo for TAK-279

    Takeda

    Hidradenitis Suppurativa

    phase 2 small molecule active

    1 trial
  35. ZB012-02-001

    Zenas BioPharma

    Systemic Lupus Erythematosus

    phase 2 small molecule active

    1 trial
  36. ZB012-02-002

    Zenas BioPharma

    RELAPSING MULTIPLE SCLEROSIS

    phase 2 small molecule active

    1 trial
  37. ZD6474

    United Therapeutics Europe Ltd

    Lung Cancer

    phase 2 small molecule completed

    2 trials
  38. ZEAL-UNLOCK

    AstraZeneca AB

    Cirrhosis of the liver is a condition in which the liver is scarred and damaged

    phase 2 small molecule active

    1 trial
  39. ZED1227 + SIGE

    Takeda

    Celiac Disease

    phase 2 small molecule active

    1 trial
  40. ZG005

    Suzhou Zelgen Biopharmaceuticals Co.,Ltd

    Biliary Tract Carcinoma

    phase 2 small molecule active

    1 trial
  41. ZIMBERELIMAB

    Arcus Biosciences

    Pancreatic Cancer

    phase 2 small molecule on hold

    1 trial
  42. ZIO-101 (Darinaparsin)

    Alaunos Therapeutics

    Multiple Myeloma

    phase 2 small molecule completed

    1 trial
  43. ZIO-201

    Alaunos Therapeutics

    Advanced Sarcoma

    phase 2 small molecule completed

    1 trial
  44. ZIV-Aflibercept

    Regeneron UK Limited

    Metastatic Uveal Melanoma

    phase 2 small molecule active

    1 trial
  45. ZL-1102 1% w/w gel BID for 16 weeks

    Hong Kong Baptist University

    Plaque Psoriasis

    phase 2 small molecule active

    1 trial
  46. ZN-d5

    Zentalis Pharmaceuticals

    Amyloidosis

    phase 2 small molecule completed

    1 trial
  47. ZN-d5 ZN-c3

    Zentalis Pharmaceuticals

    Acute Myeloid Leukemia (AML)

    phase 2 small molecule terminated

    1 trial
  48. ZP8396-23094

    Zealand Pharma A/S

    Weight management

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.