Saturday, July 11, 2026

Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

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  1. Radio-guided sentinel node biopsy

    Hospital Authority, Hong Kong

    Cancer of the Breast

    phase 2 other terminated

    1 trial
  2. Radiochemoimmunotherapy

    The First People's Hospital of Lianyungang

    Gastric Cancer

    phase 2 other active

    1 trial
  3. Radiotherapy

    The First People's Hospital of Lianyungang

    Cholangiocarcinoma

    phase 2 other terminated

    1 trial
  4. Radiotherapy Combined with Anlotinib and a Microtubule Inhibitor

    The First People's Hospital of Lianyungang

    HER2-Negative Breast Cancer

    phase 2 small molecule active

    1 trial
  5. Radiotherapy plus temozolomide

    The First People's Hospital of Lianyungang

    Glioma (Any Grade) in the Brain

    phase 2 small molecule active

    1 trial
  6. Radium-223 dichloride (Xofigo, BAY88-8223)

    Bayer HealthCare AG

    Breast Neoplasms

    phase 2 small molecule completed

    1 trial
  7. Radotinib HCl, Placebo for Radotinib HCl

    Alphapharm Pty Ltd

    Treatment of Parkinson’s disease (PD)

    phase 2 small molecule active

    1 trial
  8. Ralinepag

    United Therapeutics Europe Ltd

    Pulmonary Arterial Hypertension

    phase 2 small molecule completed

    1 trial
  9. Raltitrexed

    The First People's Hospital of Lianyungang

    Inoperable Esophageal Cancer Stage I-III

    phase 2 small molecule active

    1 trial
  10. Raludotatug Deruxtecan

    Daiichi Sankyo

    Advanced/metastatic solid tumors including gynecological cancers (endometrial cancer, cervical cancer, and nonhigh- grade serous ovarian cancer) and genitourinary cancers (urothelial cancer and ccRCC)

    phase 2 small molecule active

    1 trial
  11. Raludotatug Deruxtecan (R-DXd)

    Merck KGaA, Darmstadt, Germany

    Gastrointestinal Cancer

    phase 2 mab active

    1 trial
  12. Ramelteon

    Takeda

    Sleep Disorders, Circadian Rhythm

    phase 2 small molecule completed

    1 trial
  13. Ramelteon

    Takeda

    Sleep Disorder

    phase 2 small molecule completed

    1 trial
  14. Ramelteon

    BRIGHT MINDS BIOSCIENCES INC.

    Tobacco Use Disorder

    phase 2 small molecule completed

    1 trial
  15. Ramelteon

    Takeda

    Migraine

    phase 2 small molecule terminated

    1 trial
  16. Ramelteon and Placebo (25 possible combinations total)

    Takeda

    Chronic Insomnia

    phase 2 small molecule completed

    1 trial
  17. Ramelteon and doxepin

    Takeda

    Sleep Initiation and Maintenance Disorders

    phase 2 small molecule completed

    1 trial
  18. Ramelteon and gabapentin

    Takeda

    Sleep Initiation and Maintenance Disorders

    phase 2 small molecule completed

    1 trial
  19. Ramelteon or Placebo

    Takeda

    Sleep Apnea, Obstructive

    phase 2 small molecule completed

    1 trial
  20. Ramipril

    Quantum Biopharma

    Myocardial Infarction

    phase 2 small molecule completed

    1 trial
  21. Ramucirumab

    Eli Lilly and Company

    Gastric Adenocarcinoma

    phase 2 small molecule completed

    1 trial
  22. Randomized: 40 mg Paltusotine

    Crinetics Pharmaceuticals Europe GmbH

    Carcinoid Syndrome

    phase 2 small molecule completed

    1 trial
  23. Rapamune 1 mg/mL oral solution

    Tour Hekla

    Lingual microcystic lymphatic malformations (LMLMs) are rare congenital vascular malformations, presenting as clusters of cysts filled with lymph fluid or blood. They are responsible for a heavy burden even with small well-limited lesions because of oozing, bleeding, infections, or even speech, chewing or breathing impairment. Pain and aesthetic prejudice are also frequently reported

    phase 2 small molecule active

    1 trial
  24. Rapcabtagene autoleucel

    Novartis Pharmaceuticals

    ANCA Associated Vasculitis (AAV)

    phase 2 mab active

    1 trial
  25. Rasagiline

    Teva Pharma GmbH

    Dementia

    phase 2 small molecule completed

    1 trial
  26. Real cTBS

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Dependence

    phase 2 other completed

    1 trial
  27. Reblozyl 75 mg powder for solution for injection

    GlaxoSmithKline

    Myelofibrosis

    phase 2 small molecule active

    1 trial
  28. Recombinant Anti-IL-17A Humanized Monoclonal Antibody Injection

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Psoriasis

    phase 2 small molecule active

    1 trial
  29. Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 100 mg

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Gout Arthritis

    phase 2 small molecule active

    1 trial
  30. Recombinant COVID-19 Vaccine (CHO cell)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19 Pneumonia

    phase 2 mab active

    1 trial
  31. Recombinant COVID-19 Vaccine (CHO cell,NVSI-06-08)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19 Pneumonia

    phase 2 mab active

    1 trial
  32. Recombinant COVID-19 Vaccine (CHO cell,NVSI-06-09)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    COVID-19

    phase 2 mab active

    1 trial
  33. Recombinant Human Endostatin Injection

    The First People's Hospital of Lianyungang

    Locally Advanced Squamous Non-small Cell Lung Cancer

    phase 2 small molecule active

    1 trial
  34. Recombinant Human Erythropoiesis Injection (CHO cell)

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Chronic Renal Failure With Hemodialysis

    phase 2 small molecule active

    1 trial
  35. Recombinant Interferon Alpha

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Essential Thrombocytopenia

    phase 2 small molecule active

    2 trials
  36. Recombinant anti-PD-1 humanized monoclonal antibody injection

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Sarcoma, Soft Tissue

    phase 2 small molecule active

    1 trial
  37. Recombinant human Arylsulfatase A (rhASA)

    Takeda

    Late Infantile Metachromatic Leukodystrophy

    phase 2 mab completed

    1 trial
  38. Recombinant human arylsulfatase A

    Takeda

    Metachromatic Leukodystrophy (MLD)

    phase 2 mab completed

    1 trial
  39. Recombinant human arylsulfatase A

    Shire

    Metachromatic Leukodystrophy (MLD)

    phase 2 mab completed

    1 trial
  40. Recombinant human endostatin

    The First People's Hospital of Lianyungang

    Stage III Non-small-Cell Lung Cancer

    phase 2 small molecule completed

    1 trial
  41. Recombinant human growth hormone

    United Therapeutics Europe Ltd

    Gulf War Syndrome

    phase 2 small molecule active

    1 trial
  42. Recombinant human heparan N-sulfatase (rhHNS)

    Takeda

    Mucopolysaccharidosis (MPS)

    phase 2 mab completed

    1 trial
  43. Recombinant human heparan N-sulfatase [rhHNS]

    Takeda

    Sanfilippo Syndrome

    phase 2 small molecule completed

    1 trial
  44. Recombinant human hyaluronidase + immune globulin intravenous

    Takeda

    Primary Immunodeficiency Diseases (PID)

    phase 2 mab completed

    1 trial
  45. Recombinant human tissue kallikrein

    DiaMedica Therapeutics

    Acute Ischemic Stroke

    phase 2 small molecule completed

    1 trial
  46. Recombivax

    BRIGHT MINDS BIOSCIENCES INC.

    Hepatitis B

    phase 2 mab completed

    1 trial
  47. Recovery Line Support System

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid-Related Disorders

    phase 2 other completed

    1 trial
  48. Recovery by Choice

    BRIGHT MINDS BIOSCIENCES INC.

    Substance-Related Disorders

    phase 2 other completed

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.