Saturday, July 11, 2026

Intelligence · Clinical pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs 7,238
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

Top sponsors

Pipeline programs

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  1. Panitumumab + TAS-102

    Takeda

    Colorectal Cancer

    phase 2 small molecule completed

    1 trial
  2. Panitumumab-2003

    Takeda

    Colorectal Carcinoma

    phase 2 small molecule completed

    1 trial
  3. Panobinostat

    Zealand Pharma A/S

    Rhabdoid Tumor

    phase 2 small molecule terminated

    1 trial
  4. Panobinostat

    Novartis Pharmaceuticals

    Classical Hodgkin's Lymphoma

    phase 2 small molecule completed

    1 trial
  5. Panobinostat Capsules

    pharmaand GmbH

    Multiple Myeloma

    phase 2 small molecule completed

    1 trial
  6. Pantoprazole 40mg

    Zealand Pharma A/S

    Oncology

    phase 2 small molecule completed

    1 trial
  7. Panzem NCD

    CASI Pharmaceuticals

    Recurrent Glioblastoma Multiforme

    phase 2 small molecule completed

    1 trial
  8. Panzem Nanocrystal Colloidal Dispersion

    CASI Pharmaceuticals

    Recurrent Glioblastoma Multiforme

    phase 2 small molecule completed

    1 trial
  9. Panzem Nanocrystal Colloidal Dispersion (NCD)

    CASI Pharmaceuticals

    Ovarian Cancer

    phase 2 small molecule completed

    1 trial
  10. Panzem® NCD

    CASI Pharmaceuticals

    Prostate Cancer

    phase 2 small molecule completed

    1 trial
  11. Panzem® NCD

    CASI Pharmaceuticals

    Metastatic Renal Cell Carcinoma

    phase 2 small molecule completed

    1 trial
  12. Parenteral Remodulin (treprostinil) injection

    United Therapeutics Europe Ltd

    Pulmonary Arterial Hypertension

    phase 2 small molecule terminated

    1 trial
  13. Parenting in 2 Worlds (P2W)

    BRIGHT MINDS BIOSCIENCES INC.

    Parenting

    phase 2 other active

    1 trial
  14. Pariglasgene brecaparvovec

    Lacuna Pharma Pty Ltd

    Glycogen storage disease type Ia

    phase 2 small molecule active

    1 trial
  15. Parsaclisib

    Incyte

    Lymphoma

    phase 2 small molecule completed

    1 trial
  16. Part 1: VP-315 3 Day Dosing/Week

    Verrica Pharmaceuticals

    Basal Cell Carcinoma

    phase 2 small molecule completed

    1 trial
  17. Part A: 20 and 40 mg PRAX-944

    Chongqing Precision Biotech Co., Ltd

    Essential Tremor

    phase 2 small molecule completed

    1 trial
  18. Part A: RM-718 or placebo (matched to specific RM-718 dose cohort)

    Rhythm Pharmaceuticals Netherlands B.V.

    Hypothalamic Obesity

    phase 2 small molecule active

    1 trial
  19. Part1:Recombinant two-component COVID-19 vaccine (CHO cell)

    Jian Li

    COVID-19

    phase 2 mab completed

    1 trial
  20. Patisiran

    Alnylam Netherlands B.V.

    TTR-mediated Amyloidosis

    phase 2 small molecule completed

    1 trial
  21. Patritumab deruxtecan

    Daiichi Sankyo

    Metastatic or Locally Advanced EGFR mutated Non-Small Cell Lung Cancer (NSCLC)

    phase 2 small molecule active

    1 trial
  22. Patritumab deruxtecan

    Daiichi Sankyo

    Locally Advanced or Metastatic Solid Tumors

    phase 2 small molecule active

    1 trial
  23. Patupilone

    Novartis Pharmaceuticals

    Hepatocellular Carcinoma

    phase 2 small molecule completed

    1 trial
  24. Paxalisib

    KAZIA THERAPEUTICS LTD

    Glioblastoma

    phase 2 small molecule on hold

    1 trial
  25. Paxalisib

    KAZIA THERAPEUTICS LTD

    Childhood Cancer

    phase 2 small molecule active

    1 trial
  26. Paxalisib

    KAZIA THERAPEUTICS LTD

    Malignant Primary Gliomas

    phase 2 small molecule active

    1 trial
  27. Paxalisib (GDC-0084)

    KAZIA THERAPEUTICS LTD

    Glioblastoma, Adult

    phase 2 small molecule completed

    1 trial
  28. Pear

    NORTHWEST BIOTHERAPEUTICS INC

    Metabolic Syndrome

    phase 2 other completed

    1 trial
  29. Pectin

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Slow Transit Constipation

    phase 2 small molecule active

    1 trial
  30. Pedmark® STS

    FENNEC PHARMACEUTICALS INC.

    Solid Tumor Malignancies

    phase 2 small molecule active

    1 trial
  31. Pegcetacoplan

    Apellis Europe B.V.

    Neovascular Age-related Macular Degeneration

    phase 2 small molecule terminated

    2 trials
  32. Pegcetacoplan

    Apellis Europe B.V.

    Paroxysmal Nocturnal Hemoglobinuria (PNH)

    phase 2 small molecule active

    2 trials
  33. Pegcetacoplan

    Apellis Europe B.V.

    Transplant-Associated Thrombotic Microangiopathy

    phase 2 small molecule completed

    1 trial
  34. Pegcetacoplan

    Apellis Europe B.V.

    Geographic Atrophy

    phase 2 small molecule completed

    1 trial
  35. Pegcetacoplan (APL-2)

    Apellis Europe B.V.

    Amyotrophic Lateral Sclerosis

    phase 2 small molecule terminated

    1 trial
  36. Pegvorhyaluronidase alfa

    HALOZYME THERAPEUTICS, INC.

    Pancreatic Ductal Adenocarcinoma

    phase 2 small molecule terminated

    1 trial
  37. Pegylated Irinotecan

    Nektar Therapeutics UK Limited

    Stage IV Non-small Cell Lung Cancer (NSCLC)

    phase 2 small molecule completed

    1 trial
  38. Pegylated Irinotecan

    Nektar Therapeutics UK Limited

    Recurrent Small Cell Lung Carcinoma

    phase 2 small molecule completed

    1 trial
  39. Peiyuan Guben Tongluo Ointment (Ejiao concentrated)

    Universal Integrated

    Sarcopenia in Elderly

    phase 2 small molecule active

    1 trial
  40. Pelareorep

    ONCOLYTICS BIOTECH INC

    Anal Cancer Metastatic

    phase 2 small molecule active

    1 trial
  41. Pelareorep

    ONCOLYTICS BIOTECH INC

    Anatomic Stage IV Breast Cancer AJCC v8

    phase 2 mab active

    1 trial
  42. Pemazyre 4.5 mg tablets

    The George Institute

    locally advanced intrahepatic cholangiocarcinoma (iCCA) with FGFR2 fusions/rearrangements

    phase 2 small molecule active

    1 trial
  43. Pemazyre 4.5 mg tablets

    Ningbo Cancer Hospital

    Recurrent or metastatic solid cancer harboring a FGFR1,2 ,3 fusion/rearrangement or activating mutation, outside of the approved indications for any selective FGFR inhibitor in France

    phase 2 small molecule active

    1 trial
  44. Pembrolizumab

    Bicara Therapeutics

    Head and Neck Squamous Cell Carcinoma

    phase 2 mab active

    1 trial
  45. Pembrolizumab

    Merck KGaA, Darmstadt, Germany

    Melanoma

    phase 2 mab completed

    1 trial
  46. Pembrolizumab

    Genmab A/S

    Advanced Endometrial Cancer

    phase 2 mab terminated

    1 trial
  47. Pembrolizumab

    United Therapeutics Europe Ltd

    Castration-resistant Prostate Cancer

    phase 2 small molecule active

    1 trial
  48. Pembrolizumab

    United Therapeutics Europe Ltd

    Breast Cancer

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.