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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12357590

    Binge behavior regulators

    CLEARMIND MEDICINE INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12357615

    Compositions for the treatment of brain tumors

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12358979

    Antibodies that bind interleukin 13 and methods of use

    Apogee Therapeutics, Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12357616

    Methods of treating multiple sclerosis

    VANDA PHARMACEUTICALS INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12358863

    Nitrogen-containing derivative of substituted phenol hydroxy acid ester, and preparation and use thereof

    WEST CHINA HOSPITAL, SICHUAN UNIVERSITY · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12357705

    Negatively charged peg-lipid conjugates

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12357687

    Compositions and vaccines for treating and/or preventing viral infections, and methods of using the same

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12358976

    Methods for increasing serum concentration of phosphorous and/or 1,25-hydroxy vitamin d

    Ultragenyx Pharmaceutical Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12358988

    Proteolytically cleavable chimeric polypeptides and methods of use thereof

    The Regents of the University of California · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12358931

    3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl) propanenitrile as a JAK kinase inhibitor

    Theravance Biopharma R&D IP, LLC · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12358879

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12359223

    Systems and methods for modulating chromosomal rearrangements

    Editas Medicine, Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12359219

    Transgene cassettes designed to express a human MECP2 gene

    The Board of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12357570

    Chemoembolization agents

    The Regents of the University of California · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12357582

    Hydrophobic ion pairing and flash nanoprecipitation for formation of controlled-release nanocarrier formulations

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12357599

    Prodrugs of treprostinil

    United Therapeutics Corporation · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12358921

    Antiviral heterocyclic compounds

    Enanta Pharmaceuticals, Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12358909

    Capsazepine analogs for the treatment of cancer and other proliferative diseases

    The Board of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12358896

    LRRK2 inhibitors and methods of making and using thereof

    DENALI THERAPEUTICS INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12358892

    Metalloenzyme inhibitors for treating cancers, Alzheimer's disease, hemochromatosis, and other disorders

    Miralogx LLC · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12358210

    Resin composition for stereolithography

    KURARAY NORITAKE DENTAL INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12357702

    Peptidic diagnostic compositions

    S. M. DISCOVERY GROUP INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12357697

    Pharmaceutical compositions comprising bupropion and cysteine

    AXSOME THERAPEUTICS, INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12357640

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12357659

    Production of megakaryocytes or platelets from monocytes

    The Board of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12357666

    Traditional Chinese herbal plant composition for improving symptoms of liver cancer patients and compatibility method thereof

    The First Hospital of China Medical University · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12357617

    Discovery of novel anti-infectives for gram negative pathogens

    The Regents of the University of California · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12358952

    Compositions and methods of synthesizing shape shifting cyclic peptides (Sscp) and their use in the identification of novel therapeutic compounds

    The Regents of the University of Colorado · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12357703

    Muscle-targeting complexes comprising an anti-transferin receptor antibody linked to an oligonucleotide and method of use thereof to induce exon skipping

    Dyne Therapeutics, Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12357682

    DNA plasmid-launched live-attanuated vaccines for plus-sense singel stranded RNA

    The Board of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12357604

    Topical formulations of cannabinoids and use thereof in the treatment of pain

    INMED PHARMACEUTICALS INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12358885

    Substituted n-propylamine fused heterocyclic mescaline derivatives

    Enveric Biosciences Canada Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12357598

    Treatment of neurodevelopmental disorders

    The Regents of the University of California · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12357650

    Methods and compositions for cancer therapies that include delivery of halogenated thymidines and thymidine phosphorlylase inhibitors in combination with radiation

    Shuttle Pharmaceuticals, Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12357580

    Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids

    The Board of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12358968

    Utilization of CD39 and CD103 for identification of human tumor reactive T cells for treatment of cancer

    Providence Health & Services—Oregon · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12359178

    Methods and compositions for treatment of hunter syndrome comprising iduronate-2-sulfatase

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12357623

    Method for treating a disease or condition using a pyrazole compound or formulation thereof

    Rigel Pharmaceuticals, Inc. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12359204

    Soluble interleukin-7 receptor (SIL7R) modulating therapy to treat autoimmune diseases and cancer

    The Board of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12359220

    Guided magnetic nanostructures for targeted and high-throughput intracellular delivery

    The Regents of the University of California · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12358971

    Arena virus monoclonal antibodies and uses

    The Boad of Regents of the University of Texas System · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12358928

    Compounds, compositions and methods

    DENALI THERAPEUTICS INC. · Granted Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 10 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. AR 132581

    COMPOSICIÓN INMUNÓGENA ÚTIL PARA LA AUTOADMINISTRACIÓN POR CERDOS

    BOEHRINGER INGELHEIM VETMEDICA GMBH [DE] · Granted Wed Jul 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jul 11 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12365728

    DLL3 single domain antibodies and therapeutic compositions thereof

    Inhibrx Biosciences, Inc. · Granted Tue Jul 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12365930

    Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates

    Northwestern University · Granted Tue Jul 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12365875

    Methods for generating skeletal muscle progenitor cells

    The Regents of the University of California · Granted Tue Jul 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12365897

    RNAi agents for inhibiting expression of mucin 5AC (MUC5AC), compositions thereof, and methods of use

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Jul 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12365889

    Tunable nanoscale cages from self-assembling DNA and protein building blocks

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jul 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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