Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2041

Annual patent cliff calendar for 2041 — US pharmaceutical patents by expiration date.

Patents
2,000

Quick answer

2,000 indexed pharmaceutical patents have expiration dates in 2041. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10918666

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10918703

    Fusion proteins for treating inflammatory diseases

    The Regents of the University of California · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10918691

    Modulators of complement activity

    RA PHARMACEUTICALS, INC. · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10918673

    Immunoisolation device

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10918648

    Estrogen receptor modulator combinations

    The Regents of the University of California · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10918598

    On demand vesicle formation from vesicle precursors suitable for long-term storage

    The Regents of the University of California · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10918653

    Bovine milk oligosaccharides

    The Regents of the University of California · Granted Tue Feb 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10927349

    Platform for generating safe cell therapeutics

    The Regents of the University of California · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10927182

    Humanized BCMA antibody and BCMA-CAR-T cells

    Caribou Biosciences, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10927374

    Compositions and methods for controlling arthropod parasite and pest infestations

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10925969

    Anti-BCMA polypeptides and proteins

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10925977

    Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    The Board of Regents of the University of Texas System · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10927130

    Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors

    Valo Early Discovery, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10927373

    Compositions and methods for inhibiting gene expression of Hif2alpha

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10927435

    Compositions for the treatment of rheumatoid arthritis and methods of using same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10927377

    Modulators of APOL1 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10928391

    CD318 as a marker for, and CD318 inhibition as a treatment for, autoimmune disease

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10927372

    Compositions and methods for modulating apolipoprotein C-III expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10927362

    Processable single chain molecules and polypeptides made using same

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10927378

    Compound and method for treating myotonic dystrophy

    Sarepta Therapeutics, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10927346

    Enhanced immune effector cells and use thereof

    Fate Therapeutics, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10927193

    Gellan gum-based hydrogels, methods and uses thereof

    STEMMATTERS, BIOTECNOLOGIA E MEDICINA REGENERATIVA, S.A. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10927161

    Methods for modulating an immune response

    Cue Biopharma, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10927165

    Antibodies that neutralize botulinum neurotoxins

    The Regents of the University of California · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10927160

    Engineered invariant natural killer T (iNKT) cells and methods of making and using thereof

    The Regents of the University of California · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10927158

    T-cell modulatory multimeric polypeptides and methods of use thereof

    Cue Biopharma, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10927136

    Phosphorus prodrugs of pyrazolo-substituted pyrimidine sGC stimulators

    Cyclerion Therapeutics, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10927135

    Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates

    THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10927141

    Salts and crystal forms of GABAA positive allosteric modulator

    PRAXIS PRECISION MEDICINES, INC. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10927118

    Inhibitors of influenza virus replication and uses thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10927088

    Thymoquinone derivatives for treatment of cancer

    UNITED ARAB EMIRATES UNIVERSITY · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10926073

    Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10927124

    Compounds and compositions and uses thereof

    PGI Drug Discovery LLC · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10925902

    Genetically engineered hematopoietic stem cells and uses thereof

    Vor Biopharma Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10927089

    Diaryl thioether piperazine compounds, preparation methods and uses thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10925975

    Acidic nanoparticles for restoration of autophagy

    The Regents of the University of California · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10925961

    Vaccines with CD40 ligand as an adjuvant

    Inovio Pharmaceuticals, Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10925946

    Vaccination methods

    TURNSTONE LIMITED PARTNERSHIP · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10925972

    Glycan-dependent immunotherapeutic molecules

    The Regents of the University of California · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10925971

    Methods of treating PRLR positive breast cancer

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10925928

    Method for treating chemotherapy-induced male infertility

    The Board of Regents of the University of Texas System · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10925923

    Peptide having anti-inflammatory activity, and use thereof

    CAREGEN CO., LTD. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10925874

    Substituted pyrazolopyrimidines as glucocerebrosidase activators

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10925860

    Compositions and methods of treating cardiac fibrosis with ifetroban

    Cumberland Pharmaceuticals Inc. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10925879

    Methods of treating developmental disorders and/or seizure disorders with etifoxine

    OVID THERAPEUTICS INC. · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10925851

    Use of Tosedostat and related compounds as analgesics

    Regents of the University of Minnesota · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10925945

    Bacterial vaccines deficient in the 2-C-methyl-D-erythritol-4-phosphate pathway and methods of preparation and use thereof

    Providence Health & Services—Oregon · Granted Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10935554

    Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (SIT)

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Mar 02 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2041?

2,000 published patents in our USPTO index have expiration dates falling in calendar year 2041.