Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2041

Annual patent cliff calendar for 2041 — US pharmaceutical patents by expiration date.

Patents
2,000

Quick answer

2,000 indexed pharmaceutical patents have expiration dates in 2041. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11185674

    Targeted delivery of biologic therapeutic agents

    Northwestern University · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11185581

    Human rotavirus G9P[6] strain and use as a vaccine

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11185572

    Mesenchymal stem cells for the treatment of CNS diseases

    BRAINSTORM CELL THERAPEUTICS LTD. · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11185564

    Compositions and methods for the treatment of wounds, disorders, and diseases of the skin

    Krystal Biotech, Inc. · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11185547

    Use of reboxetine to treat narcolepsy

    AXSOME THERAPEUTICS, INC. · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11186849

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11186873

    Combination method for treating cancer by targeting immunoglobulin superfamily member 1 (IGSF1) and mesenchymal-epithelial transition factor (MET)

    Wellmarker Bio Co., LTD. · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11185601

    Alpha(v)beta(6) integrin-binding peptides and methods of use thereof

    The Regents of the University of California · Granted Tue Nov 30 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. CA 3183290

    COMPRIME COMPRENANT DE L'OPICAPONE

    ONO PHARMACEUTICAL CO [JP] · Granted Thu Dec 02 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 27 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11191842

    Injectable thermoresponsive polyelectrolytes

    Northwestern University · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11192907

    Aminopeptidase A inhibitors and pharmaceutical compositions comprising the same

    QUANTUM GENOMICS · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11191837

    Recombinant VWF formulations

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11191778

    Multifunctional linker technology containing an N4 group

    The Board of Regents of the University of Texas System · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11191758

    Use of selective serotonin 5-HT1A receptor agonists for treating side-effects of VMAT inhibitors

    Uniwersytet Jagiellonski Collegium Medicum · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11191824

    Method of purifying virus-like-particles

    The Government of the United States of America, as represented by the Secretary of Homeland Security · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11191935

    Implant delivery system with hydration promotor capability

    Nano Precision Medical, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11191747

    Pyrrole compounds

    Aligos Therapeutics, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11191727

    Multivalent nanoparticle-based vaccines

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11191737

    Enhanced delivery epinephrine compositions

    Aquestive Therapeutics, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11191750

    Use of mTOR inhibitors for treatment of familial adenomatous polyposis

    The Board of Regents of the University of Texas System · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11191757

    Combination of pimavanserin and cytochrome P450 modulators

    ACADIA Pharmaceuticals Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11191761

    SOMCL-9112 solid dispersion and preparation method thereof and SOMCL-9112 solid preparation containing SOMCL-9112 solid dispersion

    Shanghai Acebright Pharmaceuticals Group Co., Ltd. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11191763

    HIV post-exposure prophylaxis

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11191774

    Drug formulations for cancer treatment

    The Regents of the University of California · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11191818

    Use of ADAMTS13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11191780

    Extracellular matrix compositions for the treatment of cancer or immunological diseases

    Adaptive Biologix, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11191783

    Materials and methods for engineering cells and uses thereof in immuno-oncology

    CRISPR THERAPEUTICS AG · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11191813

    Lyophilized recombinant VWF formulations

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11191821

    Peptide vaccine formulations and use thereof for inducing an immune response

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11191849

    Compositions and methods for delivering messenger RNA

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11192936

    Factor VIII chimeric proteins and uses thereof

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11191843

    Multi-arm targeting anti-cancer conjugate

    BrightGene Bio-Medical Technology Co., Ltd. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11191844

    Multispecific antigen-binding molecules and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11191855

    1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof

    UNIVERSITÄTSKLINIKUM REGENSBURG · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11192861

    Human plasma kallikrein inhibitors

    BioCryst Pharmaceuticals, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11192869

    CFTR regulators and methods of use thereof

    The Regents of the University of California · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11192885

    1-heterocyclyl isochromanyl compounds and analogs for treating CNS disorders

    PGI Drug Discovery LLC · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11192886

    S1P1 agonist and application thereof

    Medshine Discovery Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11192898

    MDM2 protein degraders

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11192903

    Zirconium-89 oxine complex as a cell labeling agent for positron emission tomography

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11192923

    Polypeptides including a beta-tricalcium phosphate-binding sequence and uses thereof

    Theradaptive, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11192944

    Methods of inducing complement activity

    Bioverativ USA Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11193129

    Modulatory polynucleotides

    VOYAGER THERAPEUTICS, INC. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11192978

    Reversibly crosslinked micelle systems

    The Regents of the University of California · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11192958

    Monoclonal antibodies for use in diagnosis and therapy of cancers and autoimmune disease

    The Board of Regents of the University of Texas System · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11193128

    Compositions for modulating expression of C9ORF72 antisense transcript

    Ionis Pharmaceuticals, Inc. · Granted Tue Dec 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 02 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11197847

    Isoxazoline parasiticide formulations and methods for treating blepharitis

    Tarsus Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11197837

    Methods and compositions for interfering with extraction or conversion of a drug susceptible to abuse

    Acurx Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2041?

2,000 published patents in our USPTO index have expiration dates falling in calendar year 2041.