Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2041

Annual patent cliff calendar for 2041 — US pharmaceutical patents by expiration date.

Patents
2,000

Quick answer

2,000 indexed pharmaceutical patents have expiration dates in 2041. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11053280

    Anti-VEGF protein compositions and methods for producing the same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11052057

    Use of cysteamine and derivatives thereof to suppress tumor metastases

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11053285

    Nucleic acids encoding human immunodeficiency virus type 1 (HIV-1) N-terminal deleted gp120 immunogens and methods of use

    The Government of the United States, as represented by the Secretary of the Army · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11052064

    Compositions, methods and systems for the treatment of cutaneous disorders

    Verrica Pharmaceuticals Inc. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11052073

    Sphingosine kinase 2 inhibitor for treating coronavirus infection

    RedHill Biopharma Ltd. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11052075

    Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and administration thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11052144

    Methods of tumor vaccination

    DCPRIME B.V. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11053262

    Heterocyclic amide compounds having RORyT inhibitory action

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11053310

    Antibodies for the treatment of cancers

    The Regents of the University of California · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11053284

    Process for the preparation of cyclic depsipeptides

    OnKure, Inc. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11053314

    Methods to eliminate cancer stem cells by targeting CD47

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11053290

    Modified Tamm-Horsfall protein and related compositions and methods of use

    The United States Government as Represented by the Department of Veterans Affair · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11053309

    Methods for treating active eosinophilic esophagitis

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11053242

    [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11052118

    Enhanced stem cell composition

    Fate Therapeutics, Inc. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11052157

    Enhanced loading of intact, bacterially derived vesicles with small molecule compounds

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11052123

    Method of obtaining olive oil and extracts from olives

    Isanatur Spain S.L. · Granted Tue Jul 06 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 01 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11058678

    Substituted heterocycles as antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11059780

    Substituted pyrrolidine compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11058671

    Formulations and methods of manufacturing formulations for use in colonic evacuation

    RedHill Biopharma Ltd. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11058729

    Exosomes and miRNA to treat glaucoma

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11058645

    Inhibition of respiratory complex III by ligands that interact with a regulatory switch

    The Regents of the University of California · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11058688

    Imidazopiperazine inhibitors of transcription activating proteins

    The Board of Regents of the University of Texas System · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11058722

    Chimeric antigen receptor comprising a cartilage-oligomeric matrix protein (comp) coiled-coil spacer domain

    AUTOLUS LIMITED · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11058802

    Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications

    The Board of Regents of the University of Texas System · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11059879

    Chimeric antigen receptor molecules and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11059896

    Stabilized formulations containing anti-interleukin-4 receptor (IL-4R) antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11059907

    Antibodies that bind Notum Pectinacetylesterase

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11060089

    Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene

    Sarepta Therapeutics, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11060144

    Prediction of sleep parameter and response to sleep-inducing compound based on PER3 VNTR genotype

    VANDA PHARMACEUTICALS INC. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11061094

    Simultaneous pH and oxygen weighted MRI contrast using multi-echo chemical exchange saturation transfer imaging (ME-CEST)

    The Regents of the University of California · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11060110

    Adeno-associated virus vectors for treatment of glycogen storage disease

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11060091

    Hepatitis B virus (HBV) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11060087

    Synthetic promoters for high throughput screening and gene modulation

    The Regents of the University of California · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11059906

    Anti-CCL2 and anti-LOXL2 combination therapy for treatment of scleroderma

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11059880

    Redirected cells with MHC chimeric receptors and methods of use in immunotherapy

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11059878

    Therapeutic targeting of SET1B/compass pathway for treating cancers

    Northwestern University · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11059830

    Compounds that participate in cooperative binding and uses thereof

    Revolution Medicines, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11059817

    Potent antiviral pyrazolopyridine compounds

    The Regents of the University of California · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11059814

    Kinase inhibitors and methods for making and using

    Rigel Pharmaceuticals, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11059826

    Pteridinone compounds and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11059796

    Aryl dihydro-2H benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11059808

    Substituted phenylpyrrolecarboxamides with therapeutic activity in HIV

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11058770

    Ultrastable antibody ionic liquids

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11058766

    Universal vaccine platform

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11058728

    Restimulation of cryopreserved tumor infiltrating lymphocytes

    Iovance Biotherapeutics, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11058709

    Methods of treating breast cancer

    Ionis Pharmaceuticals, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11058704

    Inhibitors of adenosine 5′-nucleotidase

    Arcus Biosciences, Inc. · Granted Tue Jul 13 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2041?

2,000 published patents in our USPTO index have expiration dates falling in calendar year 2041.