Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10857162

    Compositions for improving cell viability and methods of use thereof

    Amylyx Pharmaceuticals, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10857126

    Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders

    Amazentis SA · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10857140

    K-Ras modulators

    The Regents of the University of California · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10857114

    Compositions and methods for treating severe pain

    Infirst Healthcare Limited · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10857139

    Substituted diazaspiroalkanes as androgen receptor modulators

    The Regents of the University of California · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10857196

    Bicyclic peptide ligands and uses thereof

    BicycleTx Limited · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10857148

    Methods for the administration of certain VMAT2 inhibitors

    Neurocrine Biosciences, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10858410

    Glycosylated peptides with pseudoproline residues and having enhanced half-lives and ability to cross the blood brain barrier

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10858399

    Peptide compositions

    RHYTHM PHARMACEUTICALS, INC. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10858335

    2,3-Disubstituted pyridine compounds as TGF-β inhibitors and methods of use

    Rigel Pharmaceuticals, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10858363

    SGC stimulators

    Cyclerion Therapeutics, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10858396

    HER2 peptide regents and methods

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10857382

    Compositions and methods for treating and preventing chronic pain

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10858634

    Vaccines and pharmaceutical compositions against foot-and-mouth disease virus

    The Government of the United States of America, as represented by the Secretary of Homeland Security · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10858633

    Method for producing foot-and-mouth disease virus (FMDV) viral proteins utilizing a modified FMDV 3C protease

    The Government of the United States of America, as represented by the Secretary of Homeland Security · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10858642

    Immunogenic arginase peptides

    IO Biotech ApS · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10858658

    Compositions and methods for inhibiting gene expression of factor XII

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10858347

    Multicyclic compounds and uses thereof

    Karyopharm Therapeutics Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10858657

    Methods for treating hypercholesterolemia

    Ionis Pharmaceuticals, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10857265

    Injectable composition for in-situ repair and regeneration of an injured ligament or tendon and methods of use

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10858627

    Regulation of mesodermal specification

    Regents of the University of Minnesota · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10858436

    PSGL-1 modulators and uses thereof

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10858416

    Methods and compositions for modification of a HLA locus

    The Board of Regents of the University of Texas System · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10858323

    HDAC inhibitors for the treatment of diabetic peripheral neuropathy

    Regenacy Pharmaceuticals, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10857225

    Smallpox vaccine for cancer treatment

    Calidi Biotherapeutics, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10857231

    Formulations of VEG antagonist fusion proteins and method of manufacturing them

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10858432

    Antibodies specific to glycosylated PD-1 and methods of use thereof

    The Board of Regents of the University of Texas System · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10858338

    Inhibitors for soluble epoxide hydrolase (SEH) and fatty acid amide hydrolase (FAAH)

    The Regents of the University of California · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10857203

    Methods and compositions for treating Huntington's disease

    Sangamo Therapeutics, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10857219

    Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10857205

    Use of a VEGF antagonist to treat angiogenic eye disorders

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10857106

    Methods and products for treating and/or delaying onset of dysplastic lesions

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10857185

    Compositions and methods for reprogramming non-neuronal cells into neuron-like cells

    BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10857137

    Methods for the administration of certain VMAT2 inhibitors

    Neurocrine Biosciences, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10857174

    Morpholino oligonucleotides useful in cancer treatment

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10857165

    Skeletal removal of bisphosphonates

    The Regents of the University of California · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10857161

    Non-hormonal steroid modulators of NF-kB for treatment of disease

    ReveraGen BioPharma, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10857184

    Materials and methods for engineering cells and uses thereof in immuno-oncology

    CRISPR THERAPEUTICS AG · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 2020384125

    GENE EDITING FOR HEMOPHILIA A WITH IMPROVED FACTOR VIII EXPRESSION

    CRISPR THERAPEUTICS AG [CH] · Granted Thu Dec 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 05 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. WO 2020246903

    INHIBITEURS DE DOPAMINE-B-HYDROXYLASE

    BIAL PORTELA & Cª S A [PT] · Granted Thu Dec 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 05 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. CA 3142348

    INHIBITEURS DE DOPAMINE-B-HYDROXYLASE

    BIAL PORTELA & CA SA [PT] · Granted Thu Dec 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 05 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10864272

    Scintillator nanocrystal-containing compositions and methods for their use

    The Regents of the University of California · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10864152

    TRPV3 agonists for the treatment of skin conditions

    Soricimed Biopharma Inc. · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10864206

    Treatment of neurodegenerative conditions by disruption of Rhes

    The Regents of the University of California · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10864254

    Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10865403

    Engineered primate cystine/cysteine degrading enzymes for therapeutic uses

    The Board of Regents of the University of Texas System · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10864270

    Nanostructured carriers for guided and targeted on-demand substance delivery

    The Regents of the University of California · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10864285

    Methods for the diagnosis and treatment of Sjögren's syndrome

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 15 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.