Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10239954

    Antibodies specific for urokinase-type plasminogen activator and methods of use thereof for treating cancer

    The Regents of the University of California · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10240149

    Reduced size self-delivering RNAi compounds

    Phio Pharmaceuticals Corp. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10239867

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10239837

    Piperidine derivatives as HDAC1/2 inhibitors

    Regenacy Pharmaceuticals, Inc. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10239918

    Cahuitamycins and methods of making and using the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10239912

    Modulators of 5′-nucleotidase, ecto and the use thereof

    Arcus Biosciences, Inc. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10240153

    Organic compositions to treat APOC3-related diseases

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10240157

    Diagnostic and screening methods for atopic dermatitis

    The Regents of the University of California · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10240152

    Compositions and methods for inhibiting expression of transthyretin

    Alnylam Pharmaceuticals, Inc. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10238734

    Compositions and methods for self-adjuvanting vaccines against microbes and tumors

    The Regents of the University of California · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10238735

    Controlled activation of complement components for use as endogenous adjuvant

    PLS-Design GmbH · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10238652

    Compounds for treatment of cancer

    Curegenix, Inc. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10240130

    CDNA clone-launched platform for high-yield production of inactivated zika virus

    The Board of Regents of the University of Texas System · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10239832

    N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10238698

    Biomarkers and combination therapies using oncolytic virus and immunomodulation

    The Board of Regents of the University of Texas System · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10238770

    Reparative cell isolation and delivery

    The Board of Regents of the University of Texas System · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10239911

    Beta-D-2′-deoxy-2′-alpha-fluoro-2′-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

    Atea Pharmaceuticals, Inc. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10238606

    Pharmaceutical compositions for the treatment of Helicobacter pylori

    RedHill Biopharma Ltd. · Granted Tue Mar 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. IT 201700108526

    COMPOSIZIONI ORALI PER IL TRATTAMENTO DEL REFLUSO GASTROESOFAGEO.

    ALFASIGMA SPA [IT] · Granted Thu Mar 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10246471

    ETP derivatives

    The Regents of the University of California · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10245255

    Compositions and methods for the treatment of obesity and related disorders

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10245259

    Methods of treating RBP4 related diseases with triazolopyridines

    Belite Bio, Inc · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10246505

    Chimeric antigen receptors to control HIV infection

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10245330

    Compositions and methods for imaging

    The Regents of the University of California · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10246483

    Bile acid analogs as FXR/TGR5 agonists and methods of use thereof

    Enanta Pharmaceuticals, Inc. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10246514

    Single domain antibodies that bind to human CD20

    United States of America as represented by the Secretary of the Air Force · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10246453

    Benzenesulfonamide compounds and their use as therapeutic agents

    Xenon Pharmaceuticals Inc. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10246707

    Method for efficient exon (44) skipping in duchenne muscular dystrophy and associated means

    BIOMARIN TECHNOLOGIES B.V. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10246713

    TMPRSS6 iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10246416

    Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides

    Akebia Therapeutics, Inc. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10246509

    Restricted immunoglobulin heavy chain mice

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10246708

    Dosages and methods for delivering lipid formulated nucleic acid molecules

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10246709

    Targeting ligands for therapeutic compounds

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10249389

    Individual and cohort pharmacological phenotype prediction platform

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10246508

    Anti eotaxin-2 antibodies that recognize additional CCR3-binding chemokines

    CHEMOMAB LTD. · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10246463

    Hypoxia-inducible factor 1 (HIF-1) inhibitors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10245322

    Nanostructured carriers for guided and targeted on-demand substance delivery

    The Regents of the University of California · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10246464

    Thienopyrimidine and thienopyridine compounds and methods of use thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. DE 102017122807

    Orales Schilddrüsentherapeutikum

    BERLIN CHEMIE AG [DE] · Granted Thu Apr 04 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 30 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10251778

    Therapeutics dispensing device and methods of making same

    The Regents of the University of California · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10251398

    Improving shelf life and color profile of resin compositions with silver nanoparticles

    The Board of Regents of the University of Texas System · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10251894

    Anticonvulsant activity of steroids

    The Regents of the University of California · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10253039

    Inhibitors of bacterial DNA gyrase with efficacy against gram-negative bacteria

    The Regents of the University of California · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10251938

    Angiopoietin-based interventions for treating cerebral malaria

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10251874

    Crystalline forms of a JAK inhibitor compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10251977

    Compositions and methods for tissue repair with extracellular matrices

    The Regents of the University of California · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10251851

    Bicyclic analgesic compounds

    Zeno Royalties & Milestones, LLC · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10251881

    Particulate materials

    Nektar Therapeutics · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.