Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10253024

    Polycyclic indoline and indolenine compounds

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10253294

    Galactose oxidase treatment of dendritic cells to improve their immunogenicity

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10253054

    Prodrugs of pyridone amides useful as modulators of sodium channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10253044

    9H-pyrimido [4,5-b]indoles and related analogs as BET bromodomain inhibitors

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10252997

    Monocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10251955

    Heparin-mimicking sulfonated reverse thermal gel for the delivery of heparin-binding therapeutic proteins

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10252039

    Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10252974

    Cationic lipid

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10251959

    Oligomer-beta blocker conjugates

    Nektar Therapeutics · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10251914

    Compositions and methods for transplantation of colon microbiota

    Regents of the University of Minnesota · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10251912

    MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10251909

    Potassium-magnesium citrate as a surrogate of the DASH diet in managing hypertension

    The Board of Regents of the University of Texas System · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10251923

    Therapeutic uses of mastic gum fractions

    REGENERA PHARMA LTD. · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10251896

    Compositions for improving cell viability and methods of use thereof

    Amylyx Pharmaceuticals, Inc. · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10251881

    Particulate materials

    Nektar Therapeutics · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10251851

    Bicyclic analgesic compounds

    Zeno Royalties & Milestones, LLC · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10251874

    Crystalline forms of a JAK inhibitor compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10251398

    Improving shelf life and color profile of resin compositions with silver nanoparticles

    The Board of Regents of the University of Texas System · Granted Tue Apr 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10258612

    Mitochondrial lipid permeable iron chelators for treating and preventing ischemia/reperfusion (I/R) injury in the heart following an ischemic event

    Northwestern University · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10259870

    Anti-ANGPTL8 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10261095

    Predictive biomarkers of clinical response to anti-LPS immunoglobulin treatment

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10258573

    Micronized insulin and micronized insulin analogues prepared under acidic conditions, and methods of manufacturing the same under acidic conditions

    Amphastar Pharmaceuticals, Inc. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10258582

    Nicotinic receptor non-competitive antagonists

    Catalyst Biosciences, Inc. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10258627

    DNA-PK inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10258686

    Materials and methods for respiratory disease control in canines

    THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEAS CONTROL AND PREVENTION · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10260069

    Selective antisense compounds and uses thereof

    Ionis Pharmaceuticals, Inc. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10261083

    Compositions and methods for detecting protease activity in biological systems

    CytomX Therapeutics, Inc. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10259780

    Treatment of cataplexy

    Jazz Pharmaceuticals International III Limited · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10260054

    Engineered organophosphorus acid anhydrolases and methods of use thereof

    The United States of America as represented by the Secretary of the Army · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10261094

    Competitive ligand binding assay for detecting neutralizing antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10260101

    C-kit oncogene mutations in melanoma

    The Regents of the University of California · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10259846

    Bouvardin derivatives and therapeutic uses thereof

    The Regents of the University of Colorado · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10259845

    Peptides whose uptake by cells is controllable

    The Regents of the University of California · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10259826

    Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds

    Rigel Pharmaceuticals, Inc. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10259824

    Complement C3d-binding compounds

    The Regents of the University of California · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10259786

    Psychotropic agents and uses thereof

    LB PHARMACEUTICALS INC. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10259781

    Imaging agents

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10258699

    Angiopep and derivatives thereof for imaging amyloids

    UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10258701

    Labeled evans blue dye derivative for in vivo serum albumin labeling

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10258655

    Synergistic bacterial compositions and methods of production and use thereof

    Seres Therapeutics, Inc. · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10258682

    Attenuated chlamydia vaccine

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10258678

    Indoleamine 2,3-dioxygenase based immunotherapy

    IO Biotech ApS · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10258635

    Formulations and compositions of vitamin D analogs for treating and preventing cancer and other diseases

    Aphios Corporation · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10258631

    Formulations of testosterone and methods of treatment therewith

    The Board of Regents of the University of Texas System · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10258630

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Compass Therapeutics LLC · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10258629

    Liposomal drug encapsulation

    The Regents of the University of California · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10258606

    Endothelin single nucleotide polymorphisms and methods of predicting β-adrenergic receptor targeting agent efficacy

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10258613

    Compositions for treating retinal degeneration and methods of production and use thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.