Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10428057

    Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease

    The Board of Regents of the University of Texas System · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10428025

    Antifungal compound process

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10426830

    Altering the immundominance hierarchy using a DNA vaccine expressing conserved regions

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10426797

    Compositions and methods for treating cancer with anti-CD33 immunotherapy

    United State of America, As Represented by the Secretary, Dept. of Health and Human Services · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10426771

    6-hydroxy-2,5,7,8-tetramethylchroman-compounds for the treatment of chronic obstructive airway diseases

    Sulfateq B.V. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10426736

    Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10428314

    Human ebola virus species and compositions and methods thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10428200

    Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups

    Northwestern University · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10428157

    Dosing regimens for use with PCSK9 inhibitors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10428143

    Modulation of stimulatory and non-stimulatory myeloid cells

    The Regents of the University of California · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10428135

    Fusion polypeptides capable of activating receptors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10426146

    Non-human animals having a humanized signal-regulatory protein gene

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10428126

    Dermaseptin-type and piscidin-type antimicrobial peptides

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10428113

    Compositions for expanding regulatory T cells (Treg), and treating autoimmune and inflammatory diseases and conditions

    The Regents of the University of California · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10428082

    Triazole derivatives of melampomagnolide B and methods of use thereof

    The Regents of the University of Colorado, a body · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10428070

    Hepatitis B antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10428119

    Pseudomonas exotoxin A with less immunogenic T cell and/or B cell epitopes

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10428115

    Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10428050

    Substituted reverse pyrimidine Bmi-1 inhibitors

    PTC THERAPEUTICS, INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10428028

    HDAC inhibitors

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10428047

    MAP kinase modulators and uses thereof

    Northwestern University · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10428056

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10428023

    Heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10428013

    Amide compound, preparation method and uses thereof

    China State Institute of Pharmaceutical Industry · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10426848

    Humanized FcγR mice

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10428008

    Nitroalkene non steroidal anti-inflammatory drugs (NA-NSAIDs) and methods of treating inflammation related conditions

    INSTITUT PASTEUR DE MONTEVIDEO · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10426810

    Tangerine peel extract and its preparation and application

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10426807

    Bone and joint protection composition and use thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10426839

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10426817

    Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics

    MacRegen, Inc. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10426799

    Methods for production of platelets from pluripotent stem cells and compositions thereof

    Astellas Institute for Regenerative Medicine · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10426790

    Treatment of allergic eye conditions with cyclodextrins

    Aldeyra Therapeutics, Inc. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10426786

    Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids

    The Regents of the University of California · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10426772

    Use of ergot alkaloids as an anthelmintic agent

    Regents of the University of Minnesota · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10426766

    Crystalline forms of an 8-azabicyclo[3.2.1]octane compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10426746

    Methods of treating developmental disorders with biguanides

    OVID THERAPEUTICS INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10426767

    Methods of treating cancer with farnesyltransferase inhibitors

    Kura Oncolofy, Inc. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10426712

    Dental polymerizable composition

    KURARAY NORITAKE DENTAL INC. · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10426730

    Oxidized cellulose microspheres

    Covidien LP · Granted Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 2019298716

    Aripiprazole Dosing Strategy

    ALKERMES PHARMA IRELAND LTD [IE] · Granted Thu Oct 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. CA 3095083

    ASSOCIATION COMPRENANT UN INHIBITEUR DE HDAC ET UN AGONISTE DE CD137 POUR LA THERAPIE DU CANCER

    4SC AG [DE] · Granted Thu Oct 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10435677

    Genetically modified human cell with a corrected mutant sickle cell mutation

    Sangamo Therapeutics, Inc. · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10435399

    HDAC6 inhibitory heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10434174

    Combination therapies using platinum agents and agents that target tumor-associated stroma or tumor cells

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10434114

    Methods of treating a bacterial infection using a fixed-dose pharmaceutical composition comprising three antibiotics

    RedHill Biopharma Ltd. · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10434078

    GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes

    The Regents of the University of California · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10434167

    Non-toxic adjuvant formulation comprising a monophosphoryl lipid A (MPLA)-containing liposome composition and a saponin

    The Government of the United States, as represented by the Secretary of the Army · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10434225

    Para-xylene films and therapeutic uses thereof

    Northwestern University · Granted Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 03 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.