Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10377695

    Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 10377739

    Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing glutarimide derivatives

    OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “PHARMENTERPRISES” · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 10377798

    Recombinant respiratory syncytial virus G protein fragments

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 10376574

    Compositions and methods for vaccination against influenza A virus

    SOUTH DAKOTA BOARD OF REGENTS · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10379109

    Systems and methods for high-resolution imaging

    The Board of Regents of the University of Texas System · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10378014

    Compositions and methods for the treatment of influenza infection

    Lakewood Amedex, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10377817

    Human antibodies to GREM1

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 10378058

    Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer

    The Board of Regents of the University of Texas System · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 10377796

    Inhibition of pulmonary fibrosis with nutlin-3a and peptides

    The Board of Regents of the University of Texas System · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 10377801

    Amelioration of chronic kidney disease

    Northwestern University · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 10377772

    Macrocyclic LRRK2 kinase inhibitors

    Oncodesign SA · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 10377751

    8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

    Theravance Biopharma R&D IP, LLC · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 10377748

    Hepatitis B core protein modulators

    ASSEMBLY BIOSCIENCES, INC. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 10377782

    Nucleotide analogs

    The Regents of the University of California · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 10376582

    Buffer formulations for enhanced antibody stability

    Outlook Therapeutics, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 10376590

    Sustained delivery formulations of risperidone compound

    Indivior UK Limited · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 10376588

    Etanercept formulations stabilized with combinations of sugars and polyols

    Coherus BioSciences, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 10376577

    Refined product obtained from rice hull and preparation process and use thereof

    China Medical University · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 10376517

    Methods of synthesizing thyroid hormone analogs and polymorphs thereof

    Madrigal Pharmaceuticals, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 10377742

    AMPK-activating heterocyclic compounds and methods for using the same

    Rigel Pharmaceuticals, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 10376598

    Targeted therapeutics

    Madrigal Pharmaceuticals, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 10376558

    Method and compositions for synchronizing time of insemination in gilts

    United-AH II, LLC · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 10376567

    Fusion molecule based on TAA variant

    The Regents of the University of California · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 10376487

    Method of treatment

    VANDA PHARMACEUTICALS INC. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 10376486

    Compositions and methods for reactivating latent viral infections

    The Regents of the University of California · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 10376510

    2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer

    Agios Pharmaceuticals, Inc. · Granted Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 08 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. CA 3089552

    PROCEDE CONTINU DE PREPARATION DE TRAZODONE

    AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO ACRAF SPA [IT] · Granted Thu Aug 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Aug 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 10383945

    Methods for DNA-dependent targeting of a cell permeant antibody

    THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VERTERANS AFFAIRS · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 10383827

    Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 10383835

    Treatment of inflammatory disorders in non-human mammals

    The Regents of the University of California · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 10385031

    Substituted piperazines as selective HDAC1,2 inhibitors

    Regenacy Pharmaceuticals, Inc. · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 10385080

    STAT6 inhibitors

    The Board of Regents of the University of Texas System · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 10383960

    Small molecule imaging of fungi by positron emission tomography scanning

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 10383940

    Copper-cysteamine and methods of use

    The Board of Regents of the University of Texas System · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 10383939

    Light-activated compositions and methods using the same

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 10383927

    Variable epitope library compositions and methods of therapeutic and prophylactic use

    Primex Clinical Laboratories, Inc. · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 10383935

    Methods of making and using live attenuated viruses

    Regents of the University of Minnesota · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 10383830

    Modulating antibacterial immunity via bacterial membrane-coated nanoparticles

    The Regents of the University of California · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 10383943

    Compositions and related methods for the treatment of cancer

    SOUTH DAKOTA BOARD OF REGENTS · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 10383952

    Ionizable cationic lipid for RNA delivery

    ARCTURUS THERAPEUTICS, INC. · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 10385070

    Chroman-spirocyclic piperidine amides as modulators of ion channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 10385085

    Crystal forms of sialic acid or salt or solvate thereof

    Ultragenyx Pharmaceutical Inc. · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 10385136

    Use of semaphorin-4D binding molecules for treating neurodegenerative disorders

    VACCINEX, INC. · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 10385360

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 10385165

    N-maleimidyl polymer derivatives

    Nektar Therapeutics · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 10385319

    Modified foot-and-mouth disease virus 3C proteases, compositions and methods thereof

    The Government of the United States of America, as represented by the Secretary of Homeland Security · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 10385395

    Diagnostic tools for response to 6-thiopurine therapy

    The Regents of the University of California · Granted Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 10391097

    Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors

    VTV THERAPEUTICS LLC · Granted Tue Aug 27 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 22 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.