Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8389515

    2,4-pyrimidinediamine compounds and prodrugs and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8389478

    Methods and compositions for treating neurodegenerative disorders and Alzheimer's disease and improving normal memory

    The Regents of the University of California · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8389231

    Assays, method and compositions that exploit a mycobacterial iron acquistion pathway in cells

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8388969

    Interleukin-1 alpha antibodies and methods of use

    XBIOTECH INC. · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8389228

    Process for the measurement of the potency of glatiramer acetate

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8389495

    Olioodeoxynucleotide and its use to induce an immune response

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8389232

    Fluorescence detection of poison oak oil

    The Regents of the University of California · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8388956

    Interleukin-1 alpha antibodies and methods of use

    XBIOTECH INC. · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8388643

    Bioabsorbable polymeric implants and a method of using the same to create occlusions

    The Regents of the University of California · Granted Tue Mar 05 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8394620

    Two-component genome flavivirus and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8394377

    Methods for treating cancer using combination therapy

    The Regents of the University of Colorado · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8394762

    Self-decontaminating coatings containing antimicrobial peptides

    United States of America as represented by the Secretary of the Air Force · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8394846

    Dual-acting antihypertensive agents

    Theravance, Inc. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8394952

    Dihydrodiazepines useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8394966

    Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid

    PTC THERAPEUTICS, INC. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8394411

    Papillomavirus pseudoviruses for detection and therapy of tumors

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8394951

    Protein kinase C inhibitors and uses thereof

    Rigel Pharmaceuticals, Inc. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8394843

    Substituted isoindoles as glucokinase activators

    Takeda California, Inc. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8394794

    Therapeutic compounds

    Regents of the University of Minnesota · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8394803

    Gyrase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8394764

    Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8394788

    Phenylsulfoxyoxazole compound inhibitors of urea transporters

    The Regents of the University of California · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8394583

    VH4 codon signature for multiple sclerosis

    The Board of Regents of the University of Texas System · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8394406

    Once daily formulations of tetracyclines

    Supernus Pharmaceuticals, Inc. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8394405

    Once daily formulations of tetracyclines

    Supernus Pharmaceuticals, Inc. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8394387

    Recombinant modified Bacillus anthracis protective antigen for use in vaccines

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8394380

    Compositions and methods for alzheimer's disease

    Primex Clinical Laboratories, Inc. · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8394375

    Antibodies for amyloid specific peptides

    The Regents of the University of California · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8394365

    Multi-arm polymer prodrugs

    Nektar Therapeutics · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8394357

    Optical determination of glucose utilizing boronic acid adducts

    The Regents of the University of California · Granted Tue Mar 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8399512

    Biocompatible biodegradable fumagillin analog conjugates

    Mersana Therapeutics, Inc. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8399445

    Acetylcysteine composition and uses thereof

    Cumberland Pharmaceuticals Inc. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8398989

    Human cystathionine β-synthase variants and methods of production thereof

    The Regents of the University of Colorado · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8399689

    Chrysophaentin antimicrobial compounds that inhibit FtsZ protein

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8399610

    HPV vaccine comprising peptides from host cell proteins

    University College Cardiff Consultants Limited · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8399666

    5-lipoxygenase-activating protein (FLAP) inhibitors

    Panmira Pharmaceuticals, LLC · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8399615

    Processes and intermediates

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8399493

    Pyridinone derivatives and their use as positive allosteric modulators of mGluR2-receptors

    Addex Pharmaceuticals S.A. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8399501

    Crystalline alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid and methods for preparing thereof

    Theravance, Inc. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8399537

    Compositions and methods for nail coatings

    Creative Nail Design Inc. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8399479

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8399478

    Thiophene-carboxamides useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8399458

    Compounds useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8399449

    Fused heterocyclic derivative and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8399472

    Compositions and methods for inhibition of the JAK pathway

    Rigel Pharmaceuticals, Inc. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8399425

    Alleviating neuropathic pain with EETs and sEH inhibitors

    The Regents of the University of California · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8399421

    Treatment for neuropathic pain due to spinal cord injury

    The Board of Regents of the University of Texas System · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8399219

    Protease activatable interferon alpha proprotein

    CytomX Therapeutics, Inc. · Granted Tue Mar 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.