Wednesday, July 8, 2026

Drug profile · INN

golodirsen

golodirsen (VYONDYS 53) is a dystrophin pre-mrna positive modulator. Associated with Sarepta Therapeutics. Route of administration: intravenous. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 20
Pipeline programs 2
News articles 0
Drug details — golodirsen
US status
approved
Class
Route
INTRAVENOUS
Patents
20
Programs
2
Data quality
0.89

Quick answer

golodirsen (VYONDYS 53) is a dystrophin pre-mrna positive modulator. Associated with Sarepta Therapeutics. Route of administration: intravenous. Current US regulatory status: approved.

Key facts

INN golodirsen
Brand VYONDYS 53
Mechanism Dystrophin pre-mRNA positive modulator
Target Dystrophin pre-mRNA
Route INTRAVENOUS
Formulation SOLUTION

Mechanism of action

Dystrophin pre-mRNA positive modulator

Primary target: Dystrophin pre-mRNA

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. 4045-301 Phase 3 · Sarepta Therapeutics · Patients with Duchenne Muscular Dystrophy Amenable to Exon 4
  2. Golodirsen 50 MG/1 ML Intravenous Solution [VYONDYS 53] Approved · Sarepta Therapeutics · Duchenne Muscular Dystrophy

Related & competitor drugs

  1. casimersen Dystrophin pre-mRNA positive modulator
  2. eteplirsen Musculo-skeletal system (M09)
  3. viltolarsen Dystrophin pre-mRNA positive modulator
  1. US 12239715

    Peptide oligonucleotide conjugates

    Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11732259

    Peptide oligonucleotide conjugates

    Expires Mon Aug 17 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11674139

    Oligonucleotides for treating expanded repeat diseases

    Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11672871

    Peptide oligonucleotide conjugates

    Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11225662

    Peptide oligonucleotide conjugates

    Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11097011

    Peptide oligonucleotide conjugates

    Expires Mon Aug 19 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11071749

    Oligonucleotide analogues targeting human LMNA

    Expires Mon Jul 22 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10675356

    Peptide oligonucleotide conjugates

    Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10577605

    Induced exon inclusion in spinal muscle atrophy

    Expires Mon Feb 27 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10487326

    Peptide oligonucleotide conjugates

    Expires Mon Nov 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10076536

    Oligonucleotide analogues targeting human LMNA

    Expires Mon Sep 13 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10066228

    Oligonucleotides for treating expanded repeat diseases

    Expires Mon Aug 30 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 9944926

    Induced exon inclusion in spinal muscle atrophy

    Expires Mon Apr 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 9920085

    Boronic acid conjugates of oligonucleotide analogues

    Expires Mon Mar 15 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 9862946

    Peptide oligonucleotide conjugates

    Expires Mon Jan 04 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 9682097

    Oligonucleotide analogues targeting human LMNA

    Expires Mon Jun 15 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9453225

    Multiple exon skipping compositions for DMD

    Expires Mon Sep 22 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9447416

    Multiple exon skipping compositions for DMD

    Expires Mon Sep 15 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9447417

    Multiple exon skipping compositions for DMD

    Expires Mon Sep 15 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9434948

    Multiple exon skipping compositions for DMD

    Expires Mon Sep 01 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is golodirsen?

golodirsen (VYONDYS 53) is a dystrophin pre-mrna positive modulator. Associated with Sarepta Therapeutics. Route of administration: intravenous. Current US regulatory status: approved.

What is the brand name for golodirsen?

VYONDYS 53 is a marketed brand name for golodirsen. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of golodirsen?

golodirsen has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.