Wednesday, July 8, 2026

Drug profile · INN

eteplirsen

eteplirsen (EXONDYS) is a dystrophin pre-mrna positive modulator. Associated with Sarepta Therapeutics. Route of administration: intravenous. Current US regulatory status: approved.

FDA: approved EMA: refused Musculo-skeletal system (M09) M09AX
US status approved
Patents linked 20
Pipeline programs 8
News articles 0
Drug details — eteplirsen
US status
approved
Class
Musculo-skeletal system (M09)
Route
INTRAVENOUS
Patents
20
Programs
8
Data quality
0.89

Quick answer

eteplirsen (EXONDYS) is a dystrophin pre-mrna positive modulator. Associated with Sarepta Therapeutics. Route of administration: intravenous. Current US regulatory status: approved.

Key facts

INN eteplirsen
Brand EXONDYS
Mechanism Dystrophin pre-mRNA positive modulator
Target Dystrophin pre-mRNA
Therapeutic class Musculo-skeletal system (M09)
Route INTRAVENOUS
Formulation SOLUTION
ATC code M09AX

Mechanism of action

Dystrophin pre-mRNA positive modulator

Primary target: Dystrophin pre-mRNA

Approval history

Authority Status Date
FDA approved
EMA refused

Pipeline programs

  1. ETEPLIRSEN (AVI-4658) Phase 3 · Sarepta Therapeutics · Duchenne Muscular Dystrophy
  2. Eteplirsen Phase 3 · Sarepta Therapeutics · Muscular Dystrophy, Duchenne
  3. eteplirsen Phase 3 · Sarepta Therapeutics · Duchenne Muscular Dystrophy (DMD)
  4. AVI-4658 (Eteplirsen) Phase 2 · Sarepta Therapeutics · Duchenne Muscular Dystrophy
  5. AVI-4658 (Eteplirsen) Phase 2 · Sarepta Therapeutics · Duchenne Muscular Dystrophy (DMD)
  6. Eteplirsen Phase 2 · Sarepta Therapeutics · Duchenne Muscular Dystrophy
  7. VESLETEPLIRSEN(SRP-5051) Phase 2 · Sarepta Therapeutics · Duchenne Muscular Dystrophy
  8. Vesleteplirsen Phase 2 · Sarepta Therapeutics · Duchenne Muscular Dystrophy

Related & competitor drugs

  1. allopurinol Musculo-skeletal system (M04)
  2. casimersen Dystrophin pre-mRNA positive modulator
  3. colchicine Musculo-skeletal system (M04)
  4. denosumab Musculo-skeletal system (M05)
  5. febuxostat Musculo-skeletal system (M04)
  6. golodirsen Dystrophin pre-mRNA positive modulator
  1. US 12239715

    Peptide oligonucleotide conjugates

    Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11732259

    Peptide oligonucleotide conjugates

    Expires Mon Aug 17 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11674139

    Oligonucleotides for treating expanded repeat diseases

    Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11672871

    Peptide oligonucleotide conjugates

    Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11225662

    Peptide oligonucleotide conjugates

    Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11097011

    Peptide oligonucleotide conjugates

    Expires Mon Aug 19 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11071749

    Oligonucleotide analogues targeting human LMNA

    Expires Mon Jul 22 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10675356

    Peptide oligonucleotide conjugates

    Expires Mon Jun 04 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10577605

    Induced exon inclusion in spinal muscle atrophy

    Expires Mon Feb 27 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10487326

    Peptide oligonucleotide conjugates

    Expires Mon Nov 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10364431

    Compositions for treating muscular dystrophy

    Expires Mon Jul 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10337003

    Compositions for treating muscular dystrophy

    Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10076536

    Oligonucleotide analogues targeting human LMNA

    Expires Mon Sep 13 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10066228

    Oligonucleotides for treating expanded repeat diseases

    Expires Mon Aug 30 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 9944926

    Induced exon inclusion in spinal muscle atrophy

    Expires Mon Apr 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 9920085

    Boronic acid conjugates of oligonucleotide analogues

    Expires Mon Mar 15 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9862946

    Peptide oligonucleotide conjugates

    Expires Mon Jan 04 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9682097

    Oligonucleotide analogues targeting human LMNA

    Expires Mon Jun 15 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9506058

    Compositions for treating muscular dystrophy

    Expires Mon Nov 24 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9453225

    Multiple exon skipping compositions for DMD

    Expires Mon Sep 22 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is eteplirsen?

eteplirsen (EXONDYS) is a dystrophin pre-mrna positive modulator. Associated with Sarepta Therapeutics. Route of administration: intravenous. Current US regulatory status: approved.

What is the brand name for eteplirsen?

EXONDYS is a marketed brand name for eteplirsen. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of eteplirsen?

eteplirsen has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.