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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 9 of 99

  1. A clinical study of MK-6050 in healthy people (MK-6050-001)

    Merck Sharp and Dohme

    Hidradenitis suppurativa

    phase 1 other active

    1 trial

  2. A clinical study of MK-6916 and placebo in healthy people (MK-6916-003)

    Merck Sharp and Dohme

    Acute and chronic Pain

    phase 1 other active

    1 trial

  3. A clinical study of MK-6916 in healthy people (MK-6916-002)

    Merck Sharp and Dohme

    Acute and Chronic Pain

    phase 1 other active

    1 trial

  4. A clinical study of MK-6916 in healthy people (MK-6916-006)

    Merck Sharp and Dohme

    Acute and chronic Pain

    phase 1 other active

    1 trial

  5. A clinical study of MK-7228 in healthy men (MK-7228-001)

    Merck Sharp and Dohme

    Atherosclerosis

    phase 1 other active

    1 trial

  6. A clinical study of the V540A vaccine in healthy adults (V540A-001)

    Merck Sharp and Dohme

    Human Papilloma virus

    phase 1 other active

    1 trial

  7. A clinical study of the V540C vaccine in healthy adults (V540C-003)

    Merck Sharp and Dohme

    Human Papilloma virus

    phase 1 other active

    1 trial

  8. A clinical trial of MK-1824 in healthy participants (MK-1824-001)

    Merck Sharp and Dohme

    Heart failure with preserved ejection fraction

    phase 1 other active

    1 trial

  9. A clinical trial of MK-4605 in healthy participants (MK-4605-001)

    Merck Sharp and Dohme

    Dementia

    phase 1 other active

    1 trial

  10. A clinical trial of MK-6050 in healthy participants (MK-6050-002)

    Merck Sharp and Dohme

    Hidradenitis suppurativa

    phase 1 other active

    1 trial

  11. A clinical trial of MK-6916 in healthy participants (MK-6916-010)

    Merck Sharp and Dohme

    Acute and Chronic pain

    phase 1 other active

    1 trial

  12. A clinical trial of MK-7228 in adults (MK-7228-002)

    Merck Sharp and Dohme

    Atherosclerosis

    phase 1 other active

    1 trial

  13. A phase I study investigating the local toler... for Tuberculosis

    Disc Medicine

    Tuberculosis

    phase 1 other active

    1 trial

  14. A phase I study of [177Lu]Lu-EVS459 in patients with ovarian and lung cancers

    Novartis Pharmaceuticals

    Advanced high-grade serous ovarian cancer (OC), Locally advanced unresectable or metastatic non-squamous non-small cell lung carcinoma (NSCLC)

    phase 1 other active

    1 trial

  15. A pilot for UDCA causes a reduction in chol…

    s.r.o.

    UDCA causes a reduction in cholesterol saturation of the bile by inhibiting cholesterol absorption in the intestine and reducing cholesterol secretion into the bile. Presumably, cholesterol gallstones are gradually dissolved by dispersion of the cholesterol and formation of liquid crystals.

    phase 1 other active

    1 trial

  16. A randomised for Depression, Cognitive dysfuncti…

    Lacuna Pharma Pty Ltd

    Depression, Cognitive dysfunction, Alzheimer’s disease

    phase 1 other active

    1 trial

  17. A randomized double-blind placebo-controlled... for Circulatory shock

    Lacuna Pharma Pty Ltd

    Circulatory shock

    phase 1 other active

    1 trial

  18. A randomized for healthy male subjects

    Lacuna Pharma Pty Ltd

    healthy male subjects

    phase 1 other active

    1 trial

  19. A research study of a new medicine (NNC0650-0013) in healthy men

    NovoThirteen

    Weight management, Diabetes mellitus type 2; healthy subjects

    phase 1 other active

    1 trial

  20. A single-dose for hypertension

    Lacuna Pharma Pty Ltd

    hypertension

    phase 1 other active

    1 trial

  21. A single-dose for infection

    Zaklady FarmaFarmaceutyczne Polpharma S.Aceutyczne Polpharma S.A.

    infection

    phase 1 other active

    1 trial

  22. A single-dose for infections

    Zaklady FarmaFarmaceutyczne Polpharma S.Aceutyczne Polpharma S.A.

    infections

    phase 1 other active

    1 trial

  23. A study in healthy men to test how BI 1569912 is processed in the body

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  24. A study in healthy men to test how BI 1584862 is processed in the body

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  25. A study in healthy people to compare two different Sifrol® tablets

    Boehringer Ingelheim

    Pharmacokinetic trial

    phase 1 other active

    1 trial

  26. A study in healthy people to compare two tablet formulations of pramipexole

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  27. A study in healthy people to test how vicadrostat affects the heart

    Boehringer Ingelheim

    Healthy volunteer trial

    phase 1 other active

    1 trial

  28. A study of ASP3082 in adults with advanced solid tumors

    Astellas Pharma GmbH

    Solid Tumor

    phase 1 other active

    1 trial

  29. A study of how CagriSema works on appetite in people with excess body weight

    NovoThirteen

    Obesity

    phase 1 other active

    1 trial

  30. A study to assess the effect of single and re... for Plaque Psoriasis

    Janssen-Cilag International N.V.

    Plaque Psoriasis

    phase 1 other active

    1 trial

  31. A study to assess the safety of ARGX-121 in Healthy Adult Participants

    argenx

    Healthy volunteers

    phase 1 other active

    1 trial

  32. A study to compare the amount of milvexian in...

    Janssen-Cilag International N.V.

    atherothrombotic and thromboembolic disorders

    phase 1 other active

    1 trial

  33. A study to compare two different aramchol formulations in healthy volunteers.

    Galmed Pharmaceuticals

    Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis, Primary sclerosing cholangitis

    phase 1 other active

    1 trial

  34. A study to evaluate how the body absorbs for Healthy Volunteers

    Janssen-Cilag International N.V.

    Healthy Volunteers

    phase 1 other active

    1 trial

  35. A study to find a suitable dose of ASP5834 in adults with solid tumors

    Astellas Pharma GmbH

    Locally advanced (unresectable) or metastatic solid tumor malignancies who harbor a KRAS mutation (G12V, G12D, G12C, G12A, G12R or G13D mutation) or KRAS amplification

    phase 1 other active

    1 trial

  36. A study to find out how healthy people tolerate a new drug called S221237.

    The George Institute

    Parkinson disease (PD)

    phase 1 other active

    1 trial

  37. A study to learn how safe the study drug BAY... for Advanced solid tumors

    Bayer AG

    Advanced solid tumors

    phase 1 other active

    1 trial

  38. A trial to learn how baxdrostat affects the heartbeat in healthy participants

    AstraZeneca AB

    Treatment-resistant hypertension, Primary aldosteronism, Uncontrolled hypertension

    phase 1 other active

    1 trial

  39. A-CAR028

    The First People's Hospital of Lianyungang

    Acute Myeloid Leukemia (AML)

    phase 1 mab active

    1 trial

  40. A0281007

    Pfizer Australia Pty Ltd

    Primary and secondary hypertension, and heart failure

    phase 1 other active

    1 trial

  41. A148_01PK2408

    Lacuna Pharma Pty Ltd

    Active psoriatic arthritis, Moderately to severely active Crohn’s disease, Moderate-to-severe plaque psoriasis, Moderately to severely active ulcerative colitis

    phase 1 other active

    1 trial

  42. A160_01AD2502

    Lacuna Pharma Pty Ltd

    Phase I study in healthy participants. Intended indication: atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis, prurigo nodularis, and chronic obstructive pulmonary disease

    phase 1 other active

    1 trial

  43. A6281331

    Pfizer Australia Pty Ltd

    Growth hormone deficiency

    phase 1 other active

    1 trial

  44. A6791042

    Pfizer Australia Pty Ltd

    long-term female contraception

    phase 1 other active

    1 trial

  45. AAV8-hCocH

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine Dependence, in Remission

    phase 1 small molecule active

    1 trial

  46. AB-101

    Artiva Biotherapeutics

    Rheumatoid Arthritis

    phase 1 small molecule active

    1 trial

  47. AB-101

    Artiva Biotherapeutics

    Lupus Nephritis - WHO Class III

    phase 1 small molecule active

    1 trial

  48. AB-101

    Arbutus Biopharma Corp

    Chronic Hepatitis b

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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