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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 73 of 99

  1. REGN728

    Regeneron UK Limited

    Healthy

    phase 1 mab completed

    1 trial

  2. REGN7508 (IV)

    Regeneron UK Limited

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  3. REGN7544

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  4. REGN7999

    Regeneron UK Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  5. REGN846

    Regeneron UK Limited

    Healthy

    phase 1 mab completed

    1 trial

  6. REGN88

    Regeneron UK Limited

    Rheumatoid Arthritis

    phase 1 mab completed

    3 trials

  7. REGN9035

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  8. REGN9533

    Regeneron UK Limited

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  9. REGN9933

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  10. REGOMA-2

    Istituto Gentili S.r.l.

    MGMT-Methylated, IDH wild-type glioblastoma

    phase 1 other active

    1 trial

  11. REL-1017

    RELMADA THERAPEUTICS, INC.

    Neuropathic Pain

    phase 1 small molecule completed

    2 trials

  12. REN001

    OnKure Therapeutics

    McArdle Disease

    phase 1 small molecule completed

    1 trial

  13. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    Muscle-invasive Transitional Cell Carcinoma of the Bladder

    phase 1 mab terminated

    1 trial

  14. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    Malignant Glioma

    phase 1 mab completed

    1 trial

  15. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    Pancreatic Adenocarcinoma

    phase 1 mab completed

    1 trial

  16. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    KRAS Mutant Metastatic Colorectal Cancer

    phase 1 mab completed

    1 trial

  17. RESTART; Autologous Transplantation of Adult...

    Disc Medicine

    Patients operated with curative intend for head and neck cancer with an indication for bilateral postoperative radiotherapy, with or without chemotherapy.

    phase 1 other active

    1 trial

  18. RHO-11-003

    Lacuna Pharma Pty Ltd

    not applicable (submitted trial is a pharmacokinetic and pharmacodynamic safety study in healthy subjects)

    phase 1 other active

    1 trial

  19. RJK-RT2831 dose-escalation phase Ia

    Nanjing Zenshine Pharmaceuticals

    Hematologic Malignancies

    phase 1 small molecule active

    1 trial

  20. RJMty19 (CD19-CAR-DNT cells)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    B-cell Non-Hodgkin's Lymphoma

    phase 1 mab active

    1 trial

  21. RLY-5836

    Relay Therapeutics

    PIK3CA Mutation

    phase 1 small molecule completed

    1 trial

  22. RLY-8161

    Relay Therapeutics

    NRAS Mutation

    phase 1 small molecule active

    1 trial

  23. RM-493

    Rhythm Pharmaceuticals Netherlands B.V.

    Overweight

    phase 1 small molecule completed

    1 trial

  24. RMC-4630

    Revolution Medicines

    Solid Tumors

    phase 1 small molecule active

    1 trial

  25. RMC-5127

    Revolution Medicines

    Non-small Cell Lung Cancer (NSCLC)

    phase 1 small molecule active

    1 trial

  26. RMC-5552

    Revolution Medicines

    Glioblastoma

    phase 1 small molecule terminated

    1 trial

  27. RMC-5552

    Revolution Medicines

    Solid Tumors

    phase 1 small molecule completed

    1 trial

  28. RMC-6291

    Revolution Medicines

    Non-Small Cell Lung Cancer (NSCLC)

    phase 1 small molecule active

    2 trials

  29. RMC-6291-001

    Revolution Medicines

    Non-Small Cell Lung Cancer (NSCLC), Pancreatic Ductal Adenocarcinoma, Advanced Solid Tumor, Colorectal Cancer (CRC)

    phase 1 other active

    1 trial

  30. RMC-6291-101

    Revolution Medicines

    Participants with Advanced KRASG12C-Mutated Solid Tumors

    phase 1 other active

    1 trial

  31. RMC-9805

    Revolution Medicines

    Non-small Cell Lung Cancer (NSCLC)

    phase 1 small molecule active

    1 trial

  32. RMC-LUNG-101A

    Revolution Medicines

    Lung Cancer

    phase 1 small molecule active

    1 trial

  33. RMC-LUNG-101B

    Revolution Medicines

    Lung Cancer

    phase 1 small molecule active

    1 trial

  34. RO5323441

    Hoffmann-La Roche

    Carcinoma, Hepatocellular

    phase 1 small molecule completed

    1 trial

  35. RO5503781

    Hoffmann-La Roche

    Neoplasms

    phase 1 small molecule completed

    1 trial

  36. RO5503781 MBP

    Hoffmann-La Roche

    Myelogenous Leukemia, Acute

    phase 1 small molecule completed

    1 trial

  37. RO7119929

    Hoffmann-La Roche

    Carcinoma, Hepatocellular

    phase 1 small molecule completed

    1 trial

  38. RO7507062

    Hoffmann-La Roche

    Systemic Lupus Erythematosus

    phase 1 small molecule active

    1 trial

  39. RP-A601

    Rocket Pharmaceuticals B.V.

    PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

    phase 1 gene therapy active

    1 trial

  40. RP-A701-0125

    Rocket Pharmaceuticals B.V.

    Dilated Cardiomyopathy (DCM)

    phase 1 gene therapy active

    1 trial

  41. RP-L301-0119

    Lacuna Pharma Pty Ltd

    Inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells, Pyruvate Kinase Deficiency

    phase 1 small molecule active

    1 trial

  42. RP-L401

    Rocket Pharmaceuticals B.V.

    Infantile Malignant Osteopetrosis

    phase 1 mab terminated

    1 trial

  43. RT-102 (80 μg)

    Rani Therapeutics Holdings

    Healthy Volunteers

    phase 1 other completed

    1 trial

  44. RT-114 is the RaniPill capsule with PG-102 for the treatment of obesity

    Rani Therapeutics Holdings

    Obesity

    phase 1 other active

    1 trial

  45. RTI-336

    BRIGHT MINDS BIOSCIENCES INC.

    Methamphetamine Dependence

    phase 1 small molecule terminated

    1 trial

  46. RUC-4 Compound

    Chongqing Precision Biotech Co., Ltd

    Coronary Disease

    phase 1 small molecule completed

    1 trial

  47. RUXOL-18-24

    Lacuna Pharma Pty Ltd

    Myelofibrosis, polycythemia vera, acute and chronic graft-versus-host-disease.

    phase 1 other active

    1 trial

  48. Rabeprazole Sodium 10mg

    Yung NA

    Gastroesophageal Reflux Disease

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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