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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 56 of 99

  1. M22-716

    AbbVie Deutschland GmbH & Co. KG

    Follicular lymphoma (FL), Chronic lymphocytic leukemia (CLL), Diffuse large b-cell lymphoma (DLBCL), B-cell malignancies

    phase 1 other active

    1 trial

  2. M22-947

    AbbVie Deutschland GmbH & Co. KG

    Relapsed/Refractory Multiple Myeloma

    phase 1 other active

    1 trial

  3. M23-001

    AbbVie Deutschland GmbH & Co. KG

    Relapsed or Refractory Multiple Myeloma (R/R MM)

    phase 1 other active

    1 trial

  4. M23-385

    AbbVie Deutschland GmbH & Co. KG

    Advanced solid tumors

    phase 1 other active

    1 trial

  5. M23-647

    AbbVie Deutschland GmbH & Co. KG

    Select B-Cell malignancies.

    phase 1 other active

    1 trial

  6. M24-291

    AbbVie Deutschland GmbH & Co. KG

    Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia

    phase 1 other active

    1 trial

  7. M24-427

    AbbVie Deutschland GmbH & Co. KG

    locally advanced or metastatic solid tumors

    phase 1 other active

    1 trial

  8. M24-742

    AbbVie Deutschland GmbH & Co. KG

    Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer

    phase 1 other active

    1 trial

  9. M24-893

    AbbVie Deutschland GmbH & Co. KG

    Non-Hodgkin's Lymphoma

    phase 1 other active

    1 trial

  10. M25-292

    AbbVie Deutschland GmbH & Co. KG

    Squamous-Cell Non-Small Cell Lung Cancer, Hepatocellular Cancer

    phase 1 other active

    1 trial

  11. M25-433

    AbbVie Deutschland GmbH & Co. KG

    Systemic Lupus Erythematosus, Sjogren's disease

    phase 1 other active

    1 trial

  12. M6229-C002

    Lacuna Pharma Pty Ltd

    Sepsis and Septic Shock

    phase 1 other active

    1 trial

  13. M9466 Alone or in Combination in Advanced Solid Tumors (DDRiver 501)

    Merck Sharp and Dohme

    Advanced solid tumors

    phase 1 other active

    1 trial

  14. MARIB-04-25

    Lacuna Pharma Pty Ltd

    cytomegalovirus (CMV) infection and/or disease that is refractory (with or without resistance) to one or more prior therapies in adult patients who have undergone hematopoietic stem cell transplantation (HSCT) or solid organ transplantation (SOT)

    phase 1 other active

    1 trial

  15. MARVEL algorithm

    Rhythm Pharmaceuticals Netherlands B.V.

    Atrioventricular Conduction Block

    phase 1 other completed

    1 trial

  16. MB02-SP

    Mabxience Research SL

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  17. MB04-A-01-23

    Mabxience Research SL

    Not applicable, Healthy Volunteers

    phase 1 other active

    1 trial

  18. MBG453

    Novartis Pharmaceuticals

    Myelodysplastic Syndromes

    phase 1 small molecule terminated

    1 trial

  19. MBX 1416 (Part A)

    MBX Biosciences

    Postbariatric Hypoglycemia

    phase 1 small molecule completed

    1 trial

  20. MBX 2109

    MBX Biosciences

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  21. MBX 2109 (Part A)

    MBX Biosciences

    Healthy

    phase 1 small molecule completed

    1 trial

  22. MBX 4291

    MBX Biosciences

    Obesity

    phase 1 small molecule active

    1 trial

  23. MC-1-50

    Chongqing Precision Biotech Co., Ltd

    Systemic Lupus Erythematosus (SLE)

    phase 1 mab active

    1 trial

  24. MC-1-50

    Chongqing Precision Biotech Co., Ltd

    B Cell Lymphoma

    phase 1 mab active

    1 trial

  25. MC-1-50

    Chongqing Precision Biotech Co., Ltd

    Acute Lymphoblastic Leukemia, in Relapse

    phase 1 mab active

    1 trial

  26. MC-FludT.18/QT

    Medac Gesellschaft fuer klinische Spezialpraeparate mbH

    Subjects with AML ( Acute myeloid leukaemia) or MDS (Myelodysplastic syndrome) undergoing allogeneic hematopoietic stem cell transplantation

    phase 1 other active

    1 trial

  27. MCA-derived MSC therapy in renal transplant recipients

    Disc Medicine

    Rejection transplanted kidney, BPAR

    phase 1 other active

    1 trial

  28. MCAM

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Use Disorder

    phase 1 small molecule active

    1 trial

  29. MCI-186

    Tanabe Pharma

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  30. MDGN-002

    Avalo Therapeutics

    Crohn Disease

    phase 1 small molecule terminated

    1 trial

  31. MDMA

    BRIGHT MINDS BIOSCIENCES INC.

    Metabolism

    phase 1 small molecule completed

    1 trial

  32. MDMA

    BRIGHT MINDS BIOSCIENCES INC.

    MDMA ('Ecstasy')

    phase 1 small molecule completed

    1 trial

  33. MEDI1341

    Takeda

    Parkinson's Disease

    phase 1 small molecule completed

    2 trials

  34. MEDITOP/2025/01

    Pari Pharma GmbH

    Comparative bioequivalence study in healthy volunteers under fasting conditions.

    phase 1 other active

    1 trial

  35. MEN2312-01

    Stemline Therapeutics B.V.

    Advanced ER+/HER2- Breast Cancer

    phase 1 other active

    1 trial

  36. MESAL-02-25

    Lacuna Pharma Pty Ltd

    ulcerative colitis

    phase 1 other active

    1 trial

  37. MESAL-03-25

    Lacuna Pharma Pty Ltd

    ulcerative colitis

    phase 1 other active

    1 trial

  38. MESAL-19-24

    Lacuna Pharma Pty Ltd

    ulcerative colitis

    phase 1 other active

    1 trial

  39. MESAL-20-24

    Lacuna Pharma Pty Ltd

    ulcerative colitis

    phase 1 other active

    1 trial

  40. MGD020

    United Therapeutics Europe Ltd

    HIV (Human Immunodeficiency Virus)

    phase 1 small molecule active

    1 trial

  41. MGL-3196

    Madrigal Pharmaceuticals EU Limited

    Healthy

    phase 1 small molecule completed

    3 trials

  42. MGL-3196

    Madrigal Pharmaceuticals EU Limited

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  43. MGL-3196 Tablet

    Madrigal Pharmaceuticals EU Limited

    Healthy

    phase 1 small molecule completed

    1 trial

  44. MK-1045-004

    Merck Sharp and Dohme

    Systemic lupus erythematosus, Rheumatoid arthritis

    phase 1 other active

    1 trial

  45. MK-2420 SAD Study

    Merck Sharp and Dohme

    Rheumatoid arthritis

    phase 1 other active

    1 trial

  46. MK-3214-002

    Merck Sharp and Dohme

    Hypercholesterolaemia

    phase 1 other active

    1 trial

  47. MK-4318 CIDF Target Engagement Study

    Merck Sharp and Dohme

    Pain

    phase 1 other active

    1 trial

  48. MK-4646 Single Ascending Dose Study and DDI in Healthy Participants

    Merck Sharp and Dohme

    HIV infection

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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