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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 48 of 99

  1. ION464

    IONIS PHARMACEUTICALS INC

    Multiple System Atrophy

    phase 1 small molecule active

    1 trial

  2. ION537

    IONIS PHARMACEUTICALS INC

    Advanced Solid Tumors

    phase 1 small molecule completed

    1 trial

  3. ION547

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  4. ION904

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  5. IONIS ANGPTL3-LRx

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 1 small molecule completed

    1 trial

  6. IONIS FXI-LRx

    IONIS PHARMACEUTICALS INC

    Healthy Participants

    phase 1 small molecule completed

    1 trial

  7. IONIS MAPTRx

    IONIS PHARMACEUTICALS INC

    Mild Alzheimer's Disease

    phase 1 small molecule completed

    1 trial

  8. IONIS TMPRSS6-Lrx

    IONIS PHARMACEUTICALS INC

    Thalassemia

    phase 1 small molecule completed

    1 trial

  9. IONIS-APO(a)-LRx

    IONIS PHARMACEUTICALS INC

    Elevated Lipoprotein(a)

    phase 1 small molecule completed

    1 trial

  10. IONIS-ENaCRx

    IONIS PHARMACEUTICALS INC

    Healthy Subjects

    phase 1 small molecule completed

    1 trial

  11. IOR-BMS-IST-002

    The George Institute

    Non-small cell lung cancer (NSCLC)

    phase 1 other active

    1 trial

  12. IOV-2001

    Iovance Biotherapeutics B.V.

    Chronic Lymphocytic Leukemia

    phase 1 mab completed

    1 trial

  13. IP

    Nurix Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  14. IP-CT-001

    Lacuna Pharma Pty Ltd

    Wound healing

    phase 1 other active

    1 trial

  15. IPH4502-101

    Lacuna Pharma Pty Ltd

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  16. IRB00173536

    BRIGHT MINDS BIOSCIENCES INC.

    Tobacco Use Disorder

    phase 1 small molecule completed

    1 trial

  17. IRST100.39

    Istituto Gentili S.r.l.

    Mesothelioma

    phase 1 other active

    1 trial

  18. IRX4204

    IO Biotech

    Parkinson's Disease

    phase 1 small molecule completed

    1 trial

  19. IRX4204

    IO Biotech

    Lung Cancer, Nonsmall Cell

    phase 1 small molecule terminated

    1 trial

  20. IRX5183

    IO Biotech

    Acute Myeloid Leukemia (AML)

    phase 1 small molecule terminated

    1 trial

  21. ISIS 325568

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  22. ISIS 333611

    IONIS PHARMACEUTICALS INC

    Familial Amyotrophic Lateral Sclerosis

    phase 1 small molecule completed

    1 trial

  23. ISIS 353512

    IONIS PHARMACEUTICALS INC

    Inflammatory Diseases

    phase 1 small molecule completed

    1 trial

  24. ISIS 388626

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 1 small molecule completed

    1 trial

  25. ISIS 681257

    IONIS PHARMACEUTICALS INC

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  26. ISU304/CB2679d/Dalcinonacog alfa 75~150 IU/kg

    CATALYST PHARMACEUTICALS, INC.

    Hemophilia B

    phase 1 mab completed

    1 trial

  27. ITF2357-60

    Italfarmaco S.p.A.

    Participants with normal hepatic function, Participants with moderate HI, Participants with mild HI

    phase 1 other active

    1 trial

  28. ITI-214 Dose A

    Takeda

    Schizophrenia

    phase 1 small molecule terminated

    1 trial

  29. ITI-333

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  30. ITX 5061

    United Therapeutics Europe Ltd

    Hepatitis C

    phase 1 small molecule completed

    1 trial

  31. IVAC MUTANOME, RBL001/RBL002

    Atrium Therapeutics

    Melanoma

    phase 1 mab completed

    1 trial

  32. IVACA-05-23

    Lacuna Pharma Pty Ltd

    Cystic Fibrosis

    phase 1 other active

    1 trial

  33. IVACFLU

    Repatha

    Influenza

    phase 1 mab completed

    1 trial

  34. IVIb

    CUMBERLAND PHARMACEUTICALS INC

    Healthy

    phase 1 small molecule completed

    1 trial

  35. IW-1701

    Cyclerion Therapeutics

    Healthy

    phase 1 small molecule completed

    2 trials

  36. IW-1973

    Cyclerion Therapeutics

    Healthy

    phase 1 small molecule completed

    2 trials

  37. IW-3300

    IRONWOOD PHARMACEUTICALS INC

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  38. IXAZOMIB

    Takeda

    Advanced Solid Tumors

    phase 1 small molecule completed

    1 trial

  39. IXAZOMIB

    Takeda

    Advanced Non-hematologic Malignancies

    phase 1 small molecule completed

    1 trial

  40. IXP

    Vertex Pharmaceuticals (Australia) Pty.

    Renal Impairment

    phase 1 small molecule completed

    1 trial

  41. IXP

    Vertex Pharmaceuticals (Australia) Pty.

    Focal Segmental Glomerulosclerosis (FSGS)

    phase 1 small molecule completed

    1 trial

  42. Ibudilast 20mg

    BRIGHT MINDS BIOSCIENCES INC.

    Methamphetamine-dependence

    phase 1 small molecule completed

    1 trial

  43. Ibuprofen

    United Therapeutics Europe Ltd

    Tonsillectomy With or Without Adenoidectomy

    phase 1 small molecule terminated

    1 trial

  44. Ibuprofen 800 mg

    United Therapeutics Europe Ltd

    Bone Resorption

    phase 1 small molecule completed

    1 trial

  45. Icatibant (30 mg)

    Takeda

    Hereditary Angioedema (HAE)

    phase 1 small molecule completed

    1 trial

  46. Image Guided Dynamic Dosimetry

    United Therapeutics Europe Ltd

    Locally Confined Adenocarcinoma of the Prostate

    phase 1 other completed

    1 trial

  47. Imatimib Mesylate

    United Therapeutics Europe Ltd

    Lymphangioleiomyomatosis (LAM)

    phase 1 small molecule active

    1 trial

  48. Imatinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Solid Tumor Cancer

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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