Saturday, July 11, 2026
🇺🇸 FDA

Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 47 of 99

  1. INAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 μg

    Hospital Authority, Hong Kong

    COVID-19 Pandemic

    phase 1 mab active

    1 trial

  2. INBRX-101/rhAAT-Fc

    Inhibrx Biosciences

    Alpha-1 Antitrypsin Deficiency

    phase 1 small molecule completed

    1 trial

  3. INBRX-105 - PDL1x41BB antibody

    Inhibrx Biosciences

    Metastatic Solid Tumors

    phase 1 small molecule terminated

    1 trial

  4. INBRX-109

    Inhibrx Biosciences

    Ewing Sarcoma

    phase 1 small molecule active

    1 trial

  5. INC280 single agent

    Novartis Pharmaceuticals

    Non-Small Cell Lung Cancer

    phase 1 small molecule terminated

    1 trial

  6. INCA 33989-101

    Incyte

    Myeloproliferative Neoplasms

    phase 1 other active

    1 trial

  7. INCA33890

    Incyte

    Solid Tumors

    phase 1 small molecule active

    1 trial

  8. INCB 123667-101

    Incyte

    Advanced or metastatic solid tumors

    phase 1 other active

    1 trial

  9. INCB 161734-101

    Incyte

    Advanced or metastatic solid tumors

    phase 1 other active

    1 trial

  10. INCB 57643-103

    Incyte

    Treatment of participants with MF, MDS, ET, or MDS/MPN

    phase 1 other active

    1 trial

  11. INCB 81776-101

    Incyte

    Advanced malignancies.

    phase 1 other active

    1 trial

  12. INCB 99280-205

    Incyte

    Solid tumor

    phase 1 small molecule active

    1 trial

  13. INCB099280

    Incyte

    Advanced Solid Tumor

    phase 1 small molecule completed

    1 trial

  14. INCB160058-101

    Incyte

    Myeloproliferative Neoplasms

    phase 1 other active

    1 trial

  15. IND 179135 Research

    Lxo Ireland Designated Activity Company

    HIV Infections

    phase 1 mab active

    1 trial

  16. IND165646

    Lxo Ireland Designated Activity Company

    Covid19

    phase 1 mab active

    1 trial

  17. INDV-2000

    Indivior Pty Ltd

    Opioid Dependence

    phase 1 small molecule completed

    1 trial

  18. INDV-2000

    BRIGHT MINDS BIOSCIENCES INC.

    Healthy Volunteer

    phase 1 small molecule completed

    1 trial

  19. INDV-2000

    Indivior Pty Ltd

    Healthy

    phase 1 small molecule completed

    1 trial

  20. INDV-6200

    Indivior Pty Ltd

    Opioid-use Disorder

    phase 1 small molecule completed

    1 trial

  21. INF904-P1.2

    InflaRx GmbH

    Not applicable, healthy volunteers

    phase 1 other active

    1 trial

  22. INF904-P1.3

    InflaRx GmbH

    Not applicable, healthy volunteers

    phase 1 other active

    1 trial

  23. INFS (Intranasal Fentanyl Spray)

    Takeda

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  24. INO-1400

    INOVIO PHARMACEUTICALS, INC.

    Breast Cancer

    phase 1 mab completed

    1 trial

  25. INO-1800

    INOVIO PHARMACEUTICALS, INC.

    Hepatitis B

    phase 1 mab completed

    1 trial

  26. INO-3106, INO-9012

    INOVIO PHARMACEUTICALS, INC.

    Aerodigestive Precancerous Lesions and Malignancies

    phase 1 mab completed

    1 trial

  27. INO-3401 + EP

    INOVIO PHARMACEUTICALS, INC.

    Healthy

    phase 1 mab completed

    1 trial

  28. INO-3605

    INOVIO PHARMACEUTICALS, INC.

    Healthy

    phase 1 mab completed

    1 trial

  29. INO-4201

    INOVIO PHARMACEUTICALS, INC.

    Ebola Virus Disease

    phase 1 mab completed

    1 trial

  30. INO-4201

    INOVIO PHARMACEUTICALS, INC.

    Ebola Vaccine

    phase 1 mab completed

    1 trial

  31. INO-4500

    INOVIO PHARMACEUTICALS, INC.

    Lassa Fever

    phase 1 small molecule completed

    2 trials

  32. INO-5401

    INOVIO PHARMACEUTICALS, INC.

    BRCA1/2 Mutation

    phase 1 small molecule active

    1 trial

  33. INO-A002

    INOVIO PHARMACEUTICALS, INC.

    Healthy Volunteers

    phase 1 mab completed

    1 trial

  34. INSIGHT

    The George Institute

    Histologically confirmed locally advanced or metastatic solid tumor (Strata A, B, D): Specification for Stratum C: Only patients with NSCLC adenocarcinomas, (squamous or adenosquamous not permitted) who are scheduled to receive platin + pembrolizumab + pemetrexed standard treatment (only for Stratum C) Specification for Stratum E: Including only metastatic or irresectable locally advanced urothelial carcinomas (only for Stratum E)

    phase 1 other active

    1 trial

  35. INT18404

    Sanofi-aventis Healthcare Pty Ltd

    Dermatitis atopic

    phase 1 other active

    1 trial

  36. INT22854

    Sanofi-aventis Healthcare Pty Ltd

    Immune Thrombocytopenia Purpura

    phase 1 other active

    1 trial

  37. INTERACT stomach

    Disc Medicine

    Stomach Cancer with metastasis in the peritoneum

    phase 1 other active

    1 trial

  38. INV21 Low Dose

    Takeda

    Hand, Foot and Mouth Disease

    phase 1 mab completed

    1 trial

  39. INXN-1001

    Alaunos Therapeutics

    Melanoma

    phase 1 small molecule completed

    1 trial

  40. INZ-701, INZ-701

    Lacuna Pharma Pty Ltd

    Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Deficiency or ATP-binding Cassette Sub-family C Member 6 (ABCC6) Deficiency

    phase 1 small molecule active

    1 trial

  41. IO-108

    BEONE MEDICINES AUS PTY LTD

    Advanced Solid Tumor

    phase 1 mab completed

    1 trial

  42. IO-108

    BEONE MEDICINES AUS PTY LTD

    Solid Tumor, Adult

    phase 1 mab completed

    1 trial

  43. IO-202

    BEONE MEDICINES AUS PTY LTD

    Solid Tumor, Adult

    phase 1 mab completed

    1 trial

  44. IO-202

    BEONE MEDICINES AUS PTY LTD

    AML With Monocytic Differentiation

    phase 1 mab completed

    1 trial

  45. ION251

    IONIS PHARMACEUTICALS INC

    Relapsed Multiple Myeloma

    phase 1 small molecule completed

    1 trial

  46. ION269

    IONIS PHARMACEUTICALS INC

    Alzheimer Disease

    phase 1 small molecule terminated

    1 trial

  47. ION269-CS1

    IONIS PHARMACEUTICALS INC

    Alzheimer’s Disease in Individuals with Down Syndrome

    phase 1 other active

    1 trial

  48. ION356

    IONIS PHARMACEUTICALS INC

    Pelizaeus-Merzbacher Disease

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.