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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 4 of 99

  1. 2019-SR-101

    The First People's Hospital of Lianyungang

    Nutritional Supplement Toxicity

    phase 1 small molecule active

    1 trial

  2. 20190135

    Amgen

    Advanced Solid Tumors Kirsten Rat Sarcoma (KRAS) pG12C Mutation

    phase 1 other active

    1 trial

  3. 2020-306-GLOB1

    Hutchmed Europe B.V.

    - Acute myeloid leukemia - Myelodysplastic syndrome/ Myeloproliferative neoplasm - Angio-immunoblastic T-cell lymphoma - Other mIDH-positive hematological malignancies (other than tumor types mentioned above)

    phase 1 other active

    1 trial

  4. 20200469

    Amgen

    Extensive Stage Small cell lung cancer (ES-SCLC)

    phase 1 other active

    1 trial

  5. 2021-003637-11

    Disc Medicine

    Patients with malignant peritoneal mesothelioma

    phase 1 other active

    1 trial

  6. 2022-523-GLOB1

    Hutchmed Europe B.V.

    Primary immune thrombocytopenia (ITP)

    phase 1 other active

    1 trial

  7. 20220028

    Amgen

    Dose Escalation: Non-small cell lung cancer (NSCLC), colorectal cancer (CRC), gastric cancer (GC), melanoma (MEL). Dose Confirmation: Lead Indication based on data from dose escalation. Dose Expansion: Tertiary Lymphoid Structure positive (TLS+) CRC, GC, and NSCLC.

    phase 1 other active

    1 trial

  8. 20230151

    Amgen

    Asthma

    phase 1 other active

    1 trial

  9. 20230167

    Amgen

    Thoracic tumors with homozygous MTAP-deletion

    phase 1 other active

    1 trial

  10. 20230223

    Amgen

    Gastrointestinal tract, biliary tract, or pancreatic cancers with homozygous methylthioadenosine phosphorylase (MTAP)-deletion

    phase 1 other active

    1 trial

  11. 20230237

    Amgen

    Newly diagnosed localized Intermediate or High‐Risk Prostate Cancer

    phase 1 other active

    1 trial

  12. 20230298

    Amgen

    Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

    phase 1 other active

    1 trial

  13. 20240031

    Amgen

    KRAS Altered Advanced or Metastatic Solid Tumors

    phase 1 other active

    1 trial

  14. 20240124

    Amgen

    Extensive Stage Small Cell Lung Cancer (ES-SCLC)

    phase 1 other active

    1 trial

  15. 2025-GMF-1

    Lacuna Pharma Pty Ltd

    peritonitis

    phase 1 small molecule active

    1 trial

  16. 2025-GMF-1

    Lacuna Pharma Pty Ltd

    peritonitis

    phase 1 small molecule active

    1 trial

  17. 2025-LIUD06004-PL-01

    Laboratorios Tillomed Spain S.L.U

    No medical condition.

    phase 1 other active

    1 trial

  18. 20250004

    Amgen

    microsatellite instability high/mismatch repair deficient (MSI-H/dMMR) solid tumors

    phase 1 other active

    1 trial

  19. 2025P000818

    Eledon Pharmaceuticals

    Kidney Failure

    phase 1 small molecule active

    1 trial

  20. 204-PKT-202301

    s.r.o.

    high blood pressure

    phase 1 other active

    1 trial

  21. 20453A

    H. Lundbeck A/S

    Active, moderate-to-severe TED

    phase 1 other active

    1 trial

  22. 20511

    Bayer AG

    Prostate cancer

    phase 1 other active

    1 trial

  23. 20653A

    H. Lundbeck A/S

    Narcolepsy

    phase 1 other active

    1 trial

  24. 208850

    GlaxoSmithKline

    Neoplasms

    phase 1 other active

    1 trial

  25. 209626 (DreaMM 12)

    GlaxoSmithKline

    Relapsed/Refractory Multiple Myeloma

    phase 1 other active

    1 trial

  26. 209627(DREAMM 13)

    GlaxoSmithKline

    Relapsed or Refractory Multiple Myeloma

    phase 1 other active

    1 trial

  27. 209664

    GlaxoSmithKline

    Multiple Myeloma

    phase 1 other active

    1 trial

  28. 21117A

    H. Lundbeck A/S

    Narcolepsy

    phase 1 other active

    1 trial

  29. 213406

    GlaxoSmithKline

    Solid Tumours

    phase 1 small molecule active

    1 trial

  30. 2138-CL-0101

    Astellas Pharma GmbH

    Gastroesophageal Junction (GEJ) Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma

    phase 1 other active

    1 trial

  31. 217228

    GlaxoSmithKline

    Neoplasms

    phase 1 other active

    1 trial

  32. 21820

    Bayer AG

    Advanced solid tumors

    phase 1 other active

    1 trial

  33. 21948

    Bayer AG

    Advanced solid tumors

    phase 1 other active

    1 trial

  34. 219728

    GlaxoSmithKline

    Healthy volunteers

    phase 1 other active

    1 trial

  35. 219729

    GlaxoSmithKline

    Mild Asthma

    phase 1 other active

    1 trial

  36. 220104

    GlaxoSmithKline

    Tuberculosis

    phase 1 other active

    1 trial

  37. 22049

    Bayer Australia Ltd

    Advanced metastatic castration-resistant prostate cancer with prostate specific membrane antigen (PSMA) expression

    phase 1 other active

    1 trial

  38. 22127

    Bayer AG

    Chronic kidney disease

    phase 1 other active

    1 trial

  39. 22128

    Bayer AG

    Chronic kidney disease

    phase 1 other active

    1 trial

  40. 221362

    GlaxoSmithKline

    Kidney Disease

    phase 1 other active

    1 trial

  41. 221377

    GlaxoSmithKline

    Autosomal Dominant Polycystic Kidney Disease

    phase 1 other active

    1 trial

  42. 221458

    GlaxoSmithKline

    Systemic Lupus Erythematosus

    phase 1 other active

    1 trial

  43. 2215-CL-5201

    Astellas Pharma GmbH

    Locally advanced or metastatic NSCLC

    phase 1 other active

    1 trial

  44. 221531

    GlaxoSmithKline

    Pulmonary Disease, Chronic Obstructive

    phase 1 other active

    1 trial

  45. 221615

    GlaxoSmithKline

    Systemic Lupus Erythematosus

    phase 1 other active

    1 trial

  46. 221794

    ViiV Healthcare Pty Ltd

    HIV Infections

    phase 1 other active

    1 trial

  47. 222110

    GlaxoSmithKline

    Hepatitis B, Chronic

    phase 1 other active

    1 trial

  48. 222261

    GlaxoSmithKline

    Respiratory Syncytial Virus Infections

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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