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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 16 of 99

  1. Amoxicillin + MMX placebo

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  2. Amphetamine

    NEUROCRINE BIOSCIENCES INC

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  3. Ampreloxetine

    Theravance Biopharma Ireland Umited

    Symptomatic Neurogenic Orthostatic Hypertension

    phase 1 small molecule completed

    1 trial

  4. Ampreloxetine <Dose A>

    Theravance Biopharma Ireland Umited

    Symptomatic Neurogenic Orthostatic Hypertension

    phase 1 small molecule completed

    1 trial

  5. An Open-Label for Solid tumors and ovarian cancer

    Lacuna Pharma Pty Ltd

    Solid tumors and ovarian cancer

    phase 1 other active

    1 trial

  6. An Ophthalmic Safety Study of New Investigational Drug in Breast Cancer Patients

    AstraZeneca AB

    Breast Cancer

    phase 1 other active

    1 trial

  7. An open label for High grade serous ovarian cancer

    Disc Medicine

    High grade serous ovarian cancer

    phase 1 other active

    1 trial

  8. An open-label for inteneded for treatment of - ac…

    Lacuna Pharma Pty Ltd

    inteneded for treatment of - active rheumatoid arthritis in adult patients, - polyarthritic forms of severe, active juvenile idiopathic arthritis, when the response to nonsteroidal anti-inflammatory drugs has been inadequate, - severe recalcitrant disabling psoriasis which is not adequately responsive to other forms of therapy and severe psoriatic arthritis in adult patients, - mild-to-moderate Crohn’s disease, either alone or in combination with corticosteroids, in adult patients refractory or intolerant to thiopurines.

    phase 1 other active

    1 trial

  9. Anagrelide 0.5 mg

    Takeda

    Healthy

    phase 1 small molecule completed

    1 trial

  10. Anastrozole

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  11. Anastrozole (Teva Pharmaceuticals USA)

    Teva Pharma GmbH

    Healthy

    phase 1 small molecule completed

    1 trial

  12. Anlotinib hydrochloride,Penpulimab

    The First People's Hospital of Lianyungang

    Colorectal Cancer

    phase 1 small molecule active

    1 trial

  13. Anplag

    United Therapeutics Europe Ltd

    Healthy

    phase 1 small molecule completed

    1 trial

  14. Anti CS6 BSIgG product (Lot PD1601105CS)

    United Therapeutics Europe Ltd

    Healthy Volunteer

    phase 1 mab completed

    1 trial

  15. Anti-BCMA CAR-T cells

    The First People's Hospital of Lianyungang

    Multiple Myeloma

    phase 1 mab active

    1 trial

  16. Anti-CD123 CAR NK cells

    Chongqing Precision Biotech Co., Ltd

    AML (Acute Myeloid Leukemia)

    phase 1 small molecule active

    1 trial

  17. Anti-CD19 UCAR-T cells

    Chongqing Precision Biotech Co., Ltd

    Dermatomyositis, Juvenile

    phase 1 small molecule active

    1 trial

  18. Anti-CD19 Universal CAR-T Cells injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

    phase 1 mab active

    1 trial

  19. Anti-CD19-CAR

    The First People's Hospital of Lianyungang

    Leukemia

    phase 1 mab active

    1 trial

  20. Anti-CD20 monoclonal antibody and the BTK inhibitor

    The First People's Hospital of Lianyungang

    Anti-CD20 Monoclonal Antibody

    phase 1 small molecule active

    1 trial

  21. Anti-CD30 CAR T cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Adult T-Cell Lymphoma/Leukaemia

    phase 1 gene therapy active

    1 trial

  22. Anti-CD5 CAR NK cells

    Chongqing Precision Biotech Co., Ltd

    T-ALL/Lymphoma

    phase 1 mab active

    1 trial

  23. Anti-CDH17 CAR-T cells infusion

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    CDH17-positive Advanced Solid Tumors

    phase 1 mab active

    1 trial

  24. Anti-CLL1 CART cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Acute Myeloid Leukemia

    phase 1 small molecule active

    1 trial

  25. Anti-GD2 ADC M3554 in Advanced Solid Tumors

    Merck Sharp and Dohme

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  26. Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

    Merck Sharp and Dohme

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  27. Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody

    Takeda

    Metastatic Adenocarcinoma of the Colon or Rectum

    phase 1 mab completed

    1 trial

  28. Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody

    Takeda

    Systemic Lupus Erythematosus

    phase 1 small molecule terminated

    1 trial

  29. Anti-SEMA4D Monoclonal Antibody VX15/2503

    VACCINEX, INC.

    Metastatic Melanoma

    phase 1 mab terminated

    1 trial

  30. Anti-SEMA4D Monoclonal Antibody VX15/2503

    VACCINEX, INC.

    Colon Carcinoma Metastatic in the Liver

    phase 1 mab completed

    1 trial

  31. Anti-human CCL24 monoclonal antibody (CM-101)

    Chemomab Therapeutics

    Healthy

    phase 1 small molecule completed

    1 trial

  32. Anti-human CCL24 monoclonal antibody (CM-101) - Part One

    Chemomab Therapeutics

    Nonalcoholic Fatty Liver Disease

    phase 1 small molecule completed

    1 trial

  33. Antibody UB-421

    United Therapeutics Europe Ltd

    HIV-1 Infection in Adults (Asymptomatic)

    phase 1 small molecule completed

    1 trial

  34. Aramchol

    Galmed Pharmaceuticals

    Healthy

    phase 1 small molecule active

    4 trials

  35. Aramchol

    Galmed Pharmaceuticals

    Healthy Volunteers

    phase 1 small molecule completed

    2 trials

  36. Aramchol

    Galmed Pharmaceuticals

    NASH

    phase 1 small molecule completed

    1 trial

  37. Aramchol free acid tablet 600mg, single dose

    Galmed Pharmaceuticals

    Hepatic Impairment

    phase 1 small molecule completed

    1 trial

  38. Aramchol meglumine

    Galmed Pharmaceuticals

    Healthy

    phase 1 small molecule active

    1 trial

  39. Arbaclofen Placarbil SR

    Indivior Pty Ltd

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  40. Aricept 5mg Tablet

    Dong Wang

    Healthy

    phase 1 small molecule active

    1 trial

  41. Aripiprazole

    BRIGHT MINDS BIOSCIENCES INC.

    Cocaine-Related Disorders

    phase 1 small molecule completed

    1 trial

  42. Arm 1 cemiplimab

    Regeneron UK Limited

    Hepatocellular Carcinoma

    phase 1 small molecule active

    1 trial

  43. Arm 1: IL13Ra2-specific CAR Tcm cells

    BRIGHT MINDS BIOSCIENCES INC.

    Recurrent Glioblastoma

    phase 1 mab active

    1 trial

  44. Arsenic trioxide

    Teva Pharma GmbH

    Chronic Myelogenous Leukemia

    phase 1 small molecule terminated

    1 trial

  45. Artesunate (Test)

    Pfizer

    Falciparum Malaria

    phase 1 small molecule completed

    1 trial

  46. Aspirin

    Regeneron UK Limited

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  47. Aspirin

    Protalix BioTherapeutics

    Bioequivalence

    phase 1 small molecule completed

    1 trial

  48. Asundexian Bayer 10mg Granules, BAY 2433334

    Bayer AG

    Prevention of thromboembolic events

    phase 1 small molecule active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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