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Intelligence · Clinical pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs 4,713
Sponsors 1,771
Drugs 4,798

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Pipeline programs

Page 12 of 99

  1. ALN-AGT01 RVR

    Alnylam Netherlands B.V.

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  2. ALN-ANG3

    Regeneron UK Limited

    Healthy Volunteers With Hyperlipidemia

    phase 1 small molecule active

    1 trial

  3. ALN-APOC3

    Regeneron UK Limited

    Dyslipidemia

    phase 1 small molecule completed

    1 trial

  4. ALN-APP

    Alnylam Netherlands B.V.

    Early-Onset Alzheimer Disease

    phase 1 small molecule active

    1 trial

  5. ALN-APP-001

    Alnylam Netherlands B.V.

    Early-onset Alzheimer's disease (EOAD)

    phase 1 other active

    1 trial

  6. ALN-BCAT

    Alnylam Netherlands B.V.

    Advanced Hepatocellular Carcinoma

    phase 1 small molecule active

    1 trial

  7. ALN-F1202

    Regeneron UK Limited

    Healthy Volunteer

    phase 1 small molecule active

    1 trial

  8. ALN-HBV

    Alnylam Netherlands B.V.

    Hepatitis B

    phase 1 small molecule terminated

    1 trial

  9. ALN-HSD

    Alnylam Netherlands B.V.

    Nonalcoholic Steatohepatitis

    phase 1 small molecule terminated

    1 trial

  10. ALN-HTT02

    Alnylam Netherlands B.V.

    Huntington's Disease

    phase 1 small molecule active

    1 trial

  11. ALN-PCS02

    Alnylam Netherlands B.V.

    Elevated LDL-Cholesterol (LDL-C)

    phase 1 small molecule completed

    1 trial

  12. ALN-PCSSC

    Alnylam Netherlands B.V.

    Hypercholesterolemia

    phase 1 small molecule completed

    1 trial

  13. ALN-PNP

    Regeneron UK Limited

    Nonalcoholic Fatty Liver Disease (NAFLD)

    phase 1 small molecule completed

    1 trial

  14. ALN-SNCA

    Regeneron UK Limited

    Parkinsons Disease

    phase 1 small molecule active

    1 trial

  15. ALN-SNCA-PD-2482

    Lacuna Pharma Pty Ltd

    Parkinson's disease

    phase 1 other active

    1 trial

  16. ALN-TTR01

    Alnylam Netherlands B.V.

    Transthyretin Mediated Amyloidosis (ATTR)

    phase 1 small molecule completed

    1 trial

  17. ALN-TTR02

    Alnylam Netherlands B.V.

    TTR-mediated Amyloidosis

    phase 1 small molecule completed

    1 trial

  18. ALN-TTRSC (revusiran)

    Alnylam Netherlands B.V.

    TTR-mediated Amyloidosis

    phase 1 small molecule completed

    1 trial

  19. ALN-TTRSC02

    Alnylam Netherlands B.V.

    Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)

    phase 1 small molecule completed

    1 trial

  20. ALN-TTRSC04

    Alnylam Netherlands B.V.

    Transthyretin-Mediated Amyloidosis

    phase 1 small molecule completed

    1 trial

  21. ALN-VSP02

    Alnylam Netherlands B.V.

    Solid Tumors

    phase 1 small molecule completed

    2 trials

  22. ALPN-101

    CNS Pharmaceuticals

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  23. ALS-002158

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatitis C, Chronic

    phase 1 small molecule terminated

    1 trial

  24. ALS-002200

    Vertex Pharmaceuticals (Australia) Pty.

    Hepatitis C, Chronic

    phase 1 small molecule completed

    1 trial

  25. ALT-801

    Timmune Biotech

    Obesity

    phase 1 small molecule completed

    1 trial

  26. ALX2004

    ALX ONCOLOGY HOLDINGS INC

    NSCLC (Advanced Non-small Cell Lung Cancer)

    phase 1 small molecule active

    1 trial

  27. ALY688ER-101

    Lacuna Pharma Pty Ltd

    NASH

    phase 1 other active

    1 trial

  28. AMBER

    TESARO Bio Netherlands B.V.

    Patients with Advanced Solid Tumors

    phase 1 other active

    1 trial

  29. AMG 509

    BEONE MEDICINES AUS PTY LTD

    Prostate Cancer

    phase 1 small molecule active

    1 trial

  30. AMO-02-MD-1-001

    Lacuna Pharma Pty Ltd

    Hepatic impairment, Healthy subjects

    phase 1 other active

    1 trial

  31. AMT-116

    Multitude Therapeutics

    Advanced Solid Tumor

    phase 1 small molecule active

    1 trial

  32. AMT-676

    Multitude Therapeutics

    Advanced Solid Tumors

    phase 1 small molecule active

    1 trial

  33. AMX0114

    Amylyx Pharmaceuticals EMEA B.V.

    ALS

    phase 1 small molecule active

    1 trial

  34. AN OPEN-LABEL for Intramuscular administration of…

    Lacuna Pharma Pty Ltd

    Intramuscular administration of triamcinolone acetonide Lisapharma (Injectable suspension of triamcinolone acetonide) is indicated for systemic corticosteroid therapy in morbid conditions such as allergic syndrome (to control severe or debilitating conditions not treatable in a conventional way), dermatoses, generalized rheumatoid arthritis and other connective tissue diseases.

    phase 1 other active

    1 trial

  35. AN2-502998

    AN2 Therapeutics

    Healthy Volunteers

    phase 1 small molecule completed

    1 trial

  36. APC148-001

    Lacuna Pharma Pty Ltd

    Urinary tract infections (UTIs)/complicated UTI (cUTI)

    phase 1 other active

    1 trial

  37. APG777

    Apogee Therapeutics

    Asthma

    phase 1 small molecule active

    1 trial

  38. APHP 211033

    Pari Pharma GmbH

    Cardiology and vascular disease

    phase 1 other active

    1 trial

  39. APHP191116

    Pari Pharma GmbH

    hematologic malignancies ; acute myeloid leukemias

    phase 1 other active

    1 trial

  40. APHP200034

    Pari Pharma GmbH

    Non-ischemic Dilated Cardiomyopathies

    phase 1 other active

    1 trial

  41. APL-1202 and APL-1501 (Single ascending dose)

    Jian Li

    Bladder Cancer

    phase 1 small molecule active

    1 trial

  42. APOC-III-L-Rx

    IONIS PHARMACEUTICALS INC

    Elevated Triglycerides (TG)

    phase 1 small molecule completed

    1 trial

  43. APR-1051

    Aprea Therapeutics

    Advanced Solid Tumor

    phase 1 small molecule active

    1 trial

  44. APR-246

    Aprea Therapeutics

    Hematologic Neoplasms

    phase 1 small molecule completed

    1 trial

  45. APR-246

    Aprea Therapeutics

    Myeloid Malignancy

    phase 1 small molecule completed

    1 trial

  46. APR-548 + Azacitidine

    Aprea Therapeutics

    MDS

    phase 1 small molecule terminated

    1 trial

  47. APR002

    BRIGHT MINDS BIOSCIENCES INC.

    COVID-19

    phase 1 small molecule completed

    1 trial

  48. APTO-253

    Aptose Biosciences

    Acute Myelogenous Leukemia in Relapse

    phase 1 small molecule terminated

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

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