Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2044

Annual patent cliff calendar for 2044 — US pharmaceutical patents by expiration date.

Patents
1,766

Quick answer

1,766 indexed pharmaceutical patents have expiration dates in 2044. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12162877

    Human dihydroorotate dehydrogenase (hDHODH) inhibitors and their use in targeting oncological diseases sensitive to pyrimidine starvation

    DRUG DISCOVERY AND CLINIC S.R.L. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12162861

    Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12162910

    Recombinant gp120 protein with V1-loop deletion

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12162870

    Anticancer compounds

    The Regents of the University of California · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12162837

    Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same

    Mebias Discovery, Inc. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12162821

    Treatment of cataplexy

    AXSOME MALTA LTD. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12161755

    Sustained release device for treatment of Parkinson's disease and other disorders

    Regents of the University of Minnesota · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12161724

    Compositions and methods related to tumor activated antibodies targeting EGFR and effector cell antigens

    JANUX THERAPEUTICS, INC. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12161717

    CD38 modulating antibody agents

    BLACK BELT THERAPEUTICS LIMITED · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12161696

    Methods of treating hemophilic arthropathy using chimeric clotting factors

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12161648

    Covalent targeting of E3 ligases

    The Regents of the University of California · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12161672

    Chimeric antigen receptor and methods of use thereof

    The Regents of the University of California · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12161621

    Methods for fructokinase mediation of alcohol craving and alcohol induced liver disease

    The Regents of the University of Colorado · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12161632

    Compositions and methods of treating cardiac fibrosis with ifetroban

    Cumberland Pharmaceuticals Inc. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12161620

    Devices and methods for facilitating and controlling use of a medication

    Jazz Pharmaceuticals, Inc. · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12161618

    Methods of identifying and treating patients with HIF-2 inhibitor resistance

    The Board of Regents of the University of Texas System · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12161607

    Combination of cannabinoids in the treatment of leukemia

    JAZZ PHARMACEUTICALS RESEARCH UK LIMITED · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12162864

    Condensed-cyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12161664

    Tetrathionate for cyanide and methylmercaptan poisoning

    The Regents of the University of California · Granted Tue Dec 10 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. WO 2024252263

    COMPOSITIONS SOLIDES DE DICHLORHYDRATE D'ÉLACESTRANT, LEURS PROCÉDÉS DE FABRICATION ET MÉTHODES DE TRAITEMENT LES UTILISANT

    BERLIN CHEMIE AG [DE] · Granted Thu Dec 12 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 07 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12168802

    Methods of diagnosing and treating CD55 deficiency, hyperactivation of complement, angiopathic thrombosis and protein losing enteropathy (CHAPLE), a newly identified orphan disease

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12168681

    Il-2 variants with reduced binding to IL-2 receptor alpha and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12168013

    Antiviral prodrugs and nanoformulations thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12168008

    Oxabicycloheptanes for modulation of immune response

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12168675

    Virus-like particles and methods of use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12168678

    Heme sequesting peptides and uses therefor

    The Board of Regents of the University of Texas System · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12168057

    IRAK degraders and uses thereof

    Kymera Therapeutics, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12168071

    Treprostinil derivatives and their use in pharmaceutical compositions

    United Therapeutics Corporation · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12168041

    Methods and compositions for CNS delivery of arylsulfatase A

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12168009

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12168688

    Antibodies and variants thereof against PD-L1

    Nanjing Legend Biotech Co., Ltd · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12168059

    Trimeric peptides for antisense delivery

    Sarepta Therapeutics, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12168691

    VHS format bi-specific antibodies specific for HER2 and VEGF and use thereof

    The Board of Regents of the University of Texas System · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12168692

    Antibodies targeting CCR2

    Granite Bio AG · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12168718

    Thermogelling supramolecular sponge as self-healing and biocompatible hydrogel

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12168767

    Modified double-stranded RNA agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12168778

    Cardiac cell reprogramming with myocardin and ASCL1

    Tenaya Therapeutics, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12169199

    Activity based host cell protein profiling

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12170134

    Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12168023

    Inhibitors of adenosine 5′-nucleotidase

    Arcus Biosciences, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12168648

    Opioid receptor modulators

    EPIODYNE, INC. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12168056

    Scintillator nanocrystal-containing compositions and methods for their use

    The Regents of the University of California · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12168054

    Method of treating cancer using a combination of entinostat and an anti-CSF-1R antibody

    Syndax Pharmaceuticals, Inc. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12168036

    Methods for treating angiogenic eye disorders with high doses of VEGF receptor fusion proteins

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 17 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 12 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. WO 2024259178

    INHIBITEURS DE GLYCOGÈNE SYNTHASE KINASE 3 ET LEURS UTILISATIONS

    BROAD INST INC [US] · Granted Thu Dec 19 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 14 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. IT 202300012522

    FLUOROMETIL-CARNITINA PER USO COME INIBITORE DI COLINA TRIMETILAMMINA (TMA) LIASI.

    ALFASIGMA SPA [IT] · Granted Sun Dec 22 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sat Dec 17 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12173324

    Differentiation of pancreatic endocrine cells

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 24 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 19 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12173307

    Methods for the purification of viral vectors

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Dec 24 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 19 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2044?

1,766 published patents in our USPTO index have expiration dates falling in calendar year 2044.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.