Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10195236

    Use of gram negative species to treat atopic dermatitis

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10195202

    Methods for modulating the amount of RNA transcripts

    PTC THERAPEUTICS, INC. · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10195291

    Compositions and methods for the manufacture of lipid nanoparticles

    Alnylam Pharmaceuticals, Inc. · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10196613

    Stem cells for modeling type 2 diabetes

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10196450

    Anti-OX40 antibodies and methods of using the same

    The Board of Regents of the University of Texas System · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10196356

    Mixed disulfide conjugates of thienopyridine compounds and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10195259

    Compositions and methods for treatment of cancer using bacteria

    Decoy Biosystems, Inc. · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10195165

    Methods of treating Prader-Willi syndrome

    OVID THERAPEUTICS INC. · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10196603

    Aligned and electrospun piezoelectric polymer fiber assembly and scaffold

    The United States of America as represented by the Administrator of NASA · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10196612

    Method of characterizing and manipulating adipose stem cell depots to a metabolically healthy state

    The United States of America as Represented by the Department of Veterens Affairs · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10196372

    MYC G-quadruplex stabilizing small molecules and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10202657

    Adeno-associated virus virions with variant capsid and methods of use thereof

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10202397

    Anti-cancer compounds targeting Ral GTPases and methods of using the same

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10202449

    Cachexia treatment

    XBIOTECH INC. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10201596

    Peptide conjugated particles for the treatment of allergy

    Northwestern University · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10201282

    Genetically encoded infrared fluorescent protease reporters

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10201547

    Method of treatment of aggression

    Supernus Pharmaceuticals, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10201609

    Method for the production of a formulation of a hypericin salt

    SANOCHEMIA PHARMAZEUTIKA AG · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10201499

    Nanoparticle formulation

    United Kingdom Research and Innovation · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10201543

    Therapeutically active compounds and their methods of use

    Agios Pharmaceuticals, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10201613

    Method of creating hydrogels through oxime bond formation

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10201603

    Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10202348

    Compositions and methods of treating retinal disease

    Aldeyra Therapeutics, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10202340

    Glucosylceramide synthase inhibitors and therapeutic methods using the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10201516

    Targeting K-Ras-mediated signaling pathways and malignancy by prostratin

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10202339

    Therapeutic compounds and compositions

    Agios Pharmaceuticals, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10202367

    Heterocyclic compounds and methods of use thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10202366

    Methods of promoting wound healing using CRM1 inhibitors

    Karyopharm Therapeutics Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10202376

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10202399

    Dihydroxy aromatic heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10201554

    Esters of 2-deoxy-monosacharides with anti proliferative activity

    The Board of Regents of the University of Texas System · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10202605

    Methods of identifying and treating poor-prognosis cancers

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10201597

    Codon-optimized lentiviral vector for stem cell reprogramming

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10202618

    Method of treating type I diabetes using an AAV vector encoding uracortin 2

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10202631

    Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for inhibiting and eradicating bacterial biofilm

    United States of America as represented by the Secretary of the Air Force · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10202578

    Chicken cells for improved virus production

    The Pirbright Institute · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10202595

    Chimeric clotting factors

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10202602

    Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups

    Sarepta Therapeutics, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10201591

    TSLP induces neutrophil mediated killing of methicillin-resistant staphylococcus aureus

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10202452

    CD3 binding polypeptides

    Aptevo Research and Development LLC · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10202603

    Modulation of huntingtin expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10202428

    Compositions and methods for the delivery of oxygen

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10202412

    β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections

    Atea Pharmaceuticals, Inc. · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10202584

    Red-shifted luciferase-luciferin pairs for enhanced bioluminescence

    The Regents of the University of California · Granted Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. CA 3072544

    SACCHAROMYCES BOULARDII POUR LE TRAITEMENT DES TROUBLES DE L'HUMEUR

    BIOCODEX [FR] · Granted Thu Feb 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10208012

    Compounds for treating inflammatory and hyperproliferative diseases

    The Board of Regents of the University of Texas System · Granted Tue Feb 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10208074

    Pyrazole compounds and method for making and using the compounds

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10206875

    Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells

    Northwestern University · Granted Tue Feb 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.