Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10322124

    6-hydroxy-2,5,7,8-tetramethylchroman-compounds for the treatment of chronic obstructive airway diseases

    Sulfateq B.V. · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 10322129

    Therapeutic compositions containing dipyridamole, treatment packs and kits including such compositions and methods for producing same

    O.D. Ocular Discovery Ltd. · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 10322125

    TGF-beta enhancing compositions for cartilage repair and methods related thereto

    The United States of America as represented by the Department of Veteran Affairs · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 10322118

    Compounds and methods for inhibiting Cif virulence factor

    THE REGENTS OF TE UNIVERSITY OF CALIFORNIA · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10322107

    N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the kappa opioid receptor

    Nektar Therapeutics · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10321689

    Antimicrobial traditional Chinese medicine composition, and preparation method and use thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10322099

    Process to prepare treprostinil, the active ingredient in remodulin®

    United Therapeutics Corporation · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 10322094

    Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

    TONIX PHARMA LIMITED · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 10322069

    Restorative resin compositions and methods of use

    The Board of Regents of the University of Texas System · Granted Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 13 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. WO 2019115709

    INHIBITEURS MITOCHONDRIALES POUR LE TRAITEMENT DE TROUBLES PROLIFÉRATIFS

    BASILEA PHARM INT AG [CH] · Granted Thu Jun 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. CA 3084733

    MATERIELS ET PROCEDES POUR TRAITER LA DYSTROPHIE DES CONES ET DES BATONNETS AUTOSOMIQUE DOMINANTE

    CRISPR THERAPEUTICS AG [CH] · Granted Thu Jun 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 15 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 10330600

    Plasmonic-magnetic bifunctional nanotubes for biological applications

    The Board of Regents of the University of Texas System · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 10328089

    Fumagillol derivatives

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 10328161

    Luciferin derivatives from bicyclic reactants and aminothiol derivatives and methods of use thereof

    The Regents of the University of California · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 10328087

    Formulations for solubilizing hormones

    Compass Therapeutics LLC · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 10329283

    G protein-coupled receptor kinase inhibitors and methods for use of the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 10327853

    System and method of performing treatment along a lumen network

    Covidien LP · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 10329339

    Anti-human papillomavirus 16 E6 T cell receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 10328160

    Hollow silica nanospheres and methods of making same

    The Regents of the University of California · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 10330685

    Markers for sepsis treatment

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 10329552

    Vaccine for livestock production systems

    The Regents of the University of California · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 10329356

    Fungal-specific metalloproteases and uses thereof

    The Regents of the University of California · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 10329353

    Specific detection tool for mesenchymal and epithelial-mesenchymal transformed circulating tumor cells

    The Board of Regents of the University of Texas System · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 10329563

    Organic compositions to treat HSF1-related diseases

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 10329343

    Methods for treating headache using antagonist antibodies directed against calcitonin gene-related peptide

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 10329338

    Nucleic acid construct encoding an agonistic anti-CD40 antibody and a type I interferon

    The Regents of the University of Colorado · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 10329298

    Inhibitors of cellular metabolic processes

    Agios Pharmaceuticals, Inc. · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 10328109

    Targeted adenoviruses and methods of making, isolating, and using

    Regents of the University of Minnesota · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 10329306

    Crystalline form of 1-(1-methyl-1H-pyrazol-4-yl)-N-((IR,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1H-indole-3-carboxamide

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 10329326

    Melanocortin 1 receptor ligands and methods of use

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 10329260

    Human plasma kallikrein inhibitors

    BioCryst Pharmaceuticals, Inc. · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 10329259

    Pyrazole derivatives and their use as cannabinoid receptor mediators

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 10328159

    Enhanced loading of intact, bacterially derived vesicles with small molecule compounds

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 10328139

    Live-attenuated vaccine against plague

    The Board of Regents of the University of Texas System · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 10328130

    Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions

    HALOZYME, INC. · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 10328095

    Resorbable oxidized cellulose embolization microspheres

    Covidien LP · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 10328115

    Modulators of complement activity

    RA PHARMACEUTICALS, INC. · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 10328040

    Therapeutic methods

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 10328026

    Synthetic nanostructures including nucleic acids and/or other entities

    Northwestern University · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 10327461

    Food thickening agent, method for producing food thickening agent

    Kent Precision Foods Group, Inc. · Granted Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 20 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 10336833

    Conjugated anti-CD38 antibodies

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 10336773

    Neprilysin inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 10335402

    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 10335460

    IL-15 and IL-15Rα heterodimer dose escalation regimens for treating conditions

    THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 10336769

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 10337029

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 10337010

    Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 10337005

    Oligonucleotide-based inhibitors comprising locked nucleic acid motif

    MIRAGEN THERAPEUTICS, INC. · Granted Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 27 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.