Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2038

Annual patent cliff calendar for 2038 — US pharmaceutical patents by expiration date.

Patents
1,509

Quick answer

1,509 indexed pharmaceutical patents have expiration dates in 2038. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10046068

    Saccharide conjugates

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10046028

    Methods and compositions for modulating PD1

    Sangamo Therapeutics, Inc. · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10046036

    Chemically modified cystathionine β-synthase enzyme for treatment of homocystinuria

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10046057

    Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy

    The Regents of the University of California · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10047028

    Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10047095

    sGC stimulators

    IRONWOOD PHARMACEUTICALS, INC. · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10047104

    Bicyclic heterocyclyl derivatives as IRAK4 inhibitors

    Aurigene Discovery Technologies Limited · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10047153

    Human antibodies to Fel d1 and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10047125

    Peptide having activity to improve skin condition and use thereof

    CAREGEN CO., LTD. · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10047147

    Neutralizing GP41 antibodies and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10047160

    Anti-EGFRvIII antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. CA 3046406

    PRODUIT DE REMPLACEMENT DE FACTEUR DE COAGULATION SANGUINE POUR UTILISATION DANS LE TRAITEMENT PROPHYLACTIQUE OU THERAPEUTIQUE DES HEMORRAGIES

    CSL BEHRING GMBH [DE] · Granted Thu Aug 16 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Aug 11 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10052362

    Glial cell line derived neurotrophic factor, obesity, and obesity-related diseases and conditions

    The United States Geovernment represented by the United States Department of Veterans Affairs · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10051880

    Hydroxybutyrate ester and medical use thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10052349

    Cell preparations for extemporaneous use, useful for healing and rejuvenation in vivo

    RegenLab USA LLC · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10053494

    Chemically activated nanocapsid functionalized for cancer targeting

    The Regents of the University of California · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10053689

    Methods for increasing efficacy of lipid formulated siRNA

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10053706

    Parental RNAi suppression of chromatin remodeling genes to control coleopteran pests

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10053514

    Human bispecific EGFRvIII and CD3 antibody engaging molecules

    The United States of America as Represented by the Secretary of Health and Human Services, National Institutes of Health · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10053417

    Neprilysin inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10052393

    Multifunctional nanomaterials for the treatment of cancer

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10052382

    Methods for using antibodies for 3′ iso-LM1 and 3′, 6′-iso-LD1tumor gangliosides

    The United States of America as Represented by the Secretary of Health (NIH) · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10052363

    Mesenchymal stem cells for the treatment of CNS diseases

    BRAINSTORM CELL THERAPEUTICS LTD. · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10052386

    Progesterone formulations

    Compass Therapeutics LLC · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10052467

    Applicator for applying a fluid to a surface

    AMNEAL PHARMACEUTICALS LLC · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10053456

    Cyclopropanamine compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10053468

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10053469

    Pyridone and aza-pyridone compounds and methods of use

    GILEAD CONNECTICUT, INC. · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10053503

    Monoclonal antibodies that neutralize anthrax toxins

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10052374

    Compositions, methods and uses for dengue virus serotype-4 constructs

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10052371

    Compositions and methods for treatment of cancer using bacteria

    Decoy Biosystems, Inc. · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10052369

    Aquaporin 2 protects cattle from ticks and tick-borne parasites

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Aug 21 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10060921

    Methods of treating transthyretin (TTR) mediated amyloidosis

    Alnylam Pharmaceuticals, Inc. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10058559

    Treatment or prevention of an intestinal disease or disorder

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10059744

    α4β7 thioether peptide dimer antagonists

    Protagonist Therapeutics, Inc. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10059762

    Anti-EGFR activatable antibodies

    CytomX Therapeutics, Inc. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10058521

    Omega-3 pentaenoic acid compositions and methods of use

    MATINAS BIOPHARMA INC. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10058614

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10059771

    Methods for treating nasal polyposis by administering an IL-4R antagonist

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10058587

    Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity

    Soricimed Biopharma Inc. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10059689

    Substituted heteroaryl compounds and methods of use

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10058554

    Sustained release small molecule drug formulation

    Indivior UK Limited · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10058557

    Methods for treating subjects with prader-willi syndrome or smith-magenis syndrome

    ESSENTIALIS, INC. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10058561

    Methods and related compositions for reduction of fat and skin tightening

    The Regents of the University of California · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10058572

    Placenta-derived multipotent stem cells

    The Regents of the University of California · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10058556

    Method of treatment of aggression

    Supernus Pharmaceuticals, Inc. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10058546

    Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxo1-5-y1)-N-(1-(2,3-dihydroxypropy1)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-y1)-1H-indol-5-y1) cyclopropanecarbox-amide and administration thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10058593

    Methods and compositions for oral administration of proteins

    Oramed Ltd. · Granted Tue Aug 28 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2038?

1,509 published patents in our USPTO index have expiration dates falling in calendar year 2038.