Wednesday, July 8, 2026

Drug profile · INN

ketamine hydrochloride

ketamine hydrochloride (KETAMINE HCL) is a glutamate [nmda] receptor negative allosteric modulator. Route of administration: injection. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 0
Pipeline programs 7
News articles 0
Drug details — ketamine hydrochloride
US status
approved
Class
Route
INJECTION
Patents
0
Programs
7
Data quality
0.84

Quick answer

ketamine hydrochloride (KETAMINE HCL) is a glutamate [nmda] receptor negative allosteric modulator. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN ketamine hydrochloride
Brand KETAMINE HCL
Mechanism Glutamate [NMDA] receptor negative allosteric modulator
Target Glutamate [NMDA] receptor
Route INJECTION
Formulation INJECTABLE

Mechanism of action

Glutamate [NMDA] receptor negative allosteric modulator

Primary target: Glutamate [NMDA] receptor

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Ketamine Hydrochloride Phase 3 · United Therapeutics Europe · Traumatic Injury
  2. Ketamine Hydrochloride Phase 3 · Camp4 Therapeutics · Suicide
  3. Ketamine Hydrochloride Phase 2 · BRIGHT MINDS BIOSCIENCES · Depression
  4. Ketamine (Ketalar) Phase 1 · Grace Therapeutics · Pain
  5. Ketamine (Ketalar) Dose Level 1 Phase 1 · Grace Therapeutics · Pain, Postoperative
  6. Ketamine Hydrochloride Approved · United Therapeutics Europe · Hemorrhage
  7. Ketamine Hydrochloride Approved · NORTHWEST BIOTHERAPEUTICS · Revision Spine Surgery

Related & competitor drugs

  1. amantadine hydrochloride Glutamate [NMDA] receptor antagonist
  2. felbamate Glutamate [NMDA] receptor antagonist
  3. memantine hydrochloride Nervous system (N06)
  4. esketamine hydrochloride Glutamate [NMDA] receptor negative allosteric modulator
  5. orphenadrine citrate Norepinephrine transporter inhibitor
  6. orphenadrine hydrochloride Norepinephrine transporter inhibitor

Frequently asked questions

What is ketamine hydrochloride?

ketamine hydrochloride (KETAMINE HCL) is a glutamate [nmda] receptor negative allosteric modulator. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for ketamine hydrochloride?

KETAMINE HCL is a marketed brand name for ketamine hydrochloride. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of ketamine hydrochloride?

ketamine hydrochloride has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.