Wednesday, July 8, 2026

Drug profile · INN

esketamine hydrochloride

esketamine hydrochloride (SPRAVATO) is a glutamate [nmda] receptor negative allosteric modulator. Route of administration: nasal. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 1
Pipeline programs 17
News articles 0
Drug details — esketamine hydrochloride
US status
approved
Class
Route
NASAL
Patents
1
Programs
17
Data quality
0.84

Quick answer

esketamine hydrochloride (SPRAVATO) is a glutamate [nmda] receptor negative allosteric modulator. Route of administration: nasal. Current US regulatory status: approved.

Key facts

INN esketamine hydrochloride
Brand SPRAVATO
Mechanism Glutamate [NMDA] receptor negative allosteric modulator
Target Glutamate [NMDA] receptor
Route NASAL
Formulation SPRAY

Mechanism of action

Glutamate [NMDA] receptor negative allosteric modulator

Primary target: Glutamate [NMDA] receptor

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Ketamine Phase 3 · United Therapeutics Europe · Chronic Pain
  2. Ketamine Phase 2 · Grace Therapeutics · Obstetric Pain
  3. Ketamine Phase 2 · BRIGHT MINDS BIOSCIENCES · Cocaine Dependence
  4. Ketamine Phase 1 · United Therapeutics Europe · Acute Depression
  5. Ketamine Phase 1 · Takeda · Ketamine-Induced Brain Activity Changes
  6. Ketamine Phase 1 · Takeda · Healthy
  7. ketamine Phase 1 · Summit Therapeutics · Multiple Sclerosis
  8. Esketamine Approved · First People's Hospital · Postpartum Depression

Related & competitor drugs

  1. amantadine hydrochloride Glutamate [NMDA] receptor antagonist
  2. felbamate Glutamate [NMDA] receptor antagonist
  3. memantine hydrochloride Nervous system (N06)
  4. ketamine hydrochloride Glutamate [NMDA] receptor negative allosteric modulator
  5. orphenadrine citrate Norepinephrine transporter inhibitor
  6. orphenadrine hydrochloride Norepinephrine transporter inhibitor

Related patents

  1. US 9592207

    Intranasal administration of ketamine to treat depression

    Expires Mon Mar 09 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is esketamine hydrochloride?

esketamine hydrochloride (SPRAVATO) is a glutamate [nmda] receptor negative allosteric modulator. Route of administration: nasal. Current US regulatory status: approved.

What is the brand name for esketamine hydrochloride?

SPRAVATO is a marketed brand name for esketamine hydrochloride. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of esketamine hydrochloride?

esketamine hydrochloride has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.