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Intelligence · Clinical Pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs
7,238

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NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

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  1. Nivolumab Subcutaneous, BMS986482, FDC Nivolumab + Relatlimab + rHuPH20 Injection, BMS986482, BEVACIZUMAB

    Bristol-Myers Squibb Australia Pty Ltd

    Advanced Solid Tumors

    phase 2 small molecule active

    1 trial

  2. NoV GI.1/GII.4 Bivalent VLP Vaccine

    Takeda

    Norovirus

    phase 2 mab completed

    1 trial

  3. NoV Placebo-matching Saline

    Takeda

    Healthy Volunteers

    phase 2 mab completed

    1 trial

  4. NoV Vaccine

    Takeda

    Healthy Volunteers

    phase 2 mab completed

    1 trial

  5. Non-invasive ventilation

    United Therapeutics Europe Ltd

    Amyotrophic Lateral Sclerosis (ALS)

    phase 2 other active

    1 trial

  6. Normix 200 mg compresse rivestite con film, The placebo is a film-coated oral tablet designed to be comparable in appearance, administration, and handling to the investigational medicinal product (rifaximin 200 mg film-coated tablets), while containing no active pharmaceutical ingredient. The placebo consists exclusively of commonly used pharmaceutical excipients with established safety profiles and is administered solely to maintain blinding in the clinical trial.

    Fondazione Telethon ETS

    substance use disorder

    phase 2 small molecule active

    1 trial

  7. Norovirus Bivalent VLP Vaccine

    Takeda

    Norovirus Prevention

    phase 2 mab completed

    1 trial

  8. Norovirus Bivalent Vaccine

    Takeda

    Prevention From Norovirus Infection

    phase 2 mab completed

    1 trial

  9. Norovirus GI.1/GII.4 Bivalent VLP Vaccine

    Takeda

    Norovirus

    phase 2 mab completed

    1 trial

  10. Norwalk VLP vaccine

    Takeda

    Acute Gastroenteritis

    phase 2 mab completed

    1 trial

  11. Not the same excipients as Test, Balinatunfib

    Sanofi-aventis Healthcare Pty Ltd

    Colitis Ulcerative

    phase 2 small molecule active

    1 trial

  12. Novo Nordisk GlucaGen®

    Xeris Biopharma Holdings

    Hypoglycemia

    phase 2 small molecule completed

    1 trial

  13. Noxafil 300 mg concentrate for solution for infusion, Posaconazole, Posaconazole

    Merck Sharp and Dohme

    Fungal infection

    phase 2 small molecule active

    1 trial

  14. NurOwn (MSC-NTF cells)

    BRAINSTORM CELL THERAPEUTICS INC.

    Multiple Sclerosis, Chronic Progressive

    phase 2 mab completed

    1 trial

  15. OBINUTUZUMAB, Zanubrutinib

    BeiGene

    Relapsed/Refractory Follicular Lymphoma

    phase 2 small molecule active

    1 trial

  16. OCALIVA, Placebo for Bezafibrate, Bezalip Mono, Placebo for Obeticholic Acid, Bezalip, OCALIVA

    Lacuna Pharma Pty Ltd

    Primary Biliary Cholangitis (PBC)

    phase 2 small molecule active

    1 trial

  17. OCTREOTIDE ACETATE, Paltusotine tablets

    Lacuna Pharma Pty Ltd

    Carcinoid Syndrome

    phase 2 small molecule active

    1 trial

  18. OD-07656

    Odyssey Therapeutics

    Ulcerative Colitis (UC)

    phase 2 small molecule active

    1 trial

  19. OD-07656, OD-07656, Entyvio 300 mg powder for concentrate for solution for infusion

    Odyssey Therapeutics

    Moderately to Severely Active Ulcerative Colitis

    phase 2 small molecule active

    1 trial

  20. ODM-111 Placebo, Para-Tabs 500 mg tabletti, ODM-111, ODM-111

    Orion Laboratories Pty.

    Chronic Pain due to Ostheoarthritis of the knee

    phase 2 small molecule active

    1 trial

  21. OGX-011

    United Therapeutics Europe Ltd

    Prostate Cancer

    phase 2 mab completed

    1 trial

  22. OKI-179 + binimetinib

    OnKure Therapeutics

    RAS Mutation

    phase 2 small molecule completed

    1 trial

  23. OLAPARIB, BEVACIZUMAB

    The George Institute

    Advanced FIGO Stage III‐IV High Grade Serous or Endometrioid Ovarian, Fallopian Tube, or Peritoneal Cancer

    phase 2 small molecule active

    1 trial

  24. OMC and pseudo-SDT

    The First People's Hospital of Lianyungang

    Peripheral Arterial Disease

    phase 2 other completed

    1 trial

  25. OMEPRAZOLE , ACETYLSALICYLIC ACID

    The George Institute

    Colorectal cancer

    phase 2 small molecule active

    1 trial

  26. OMP-59R5

    Mereo BioPharma Group plc

    Stage IV Pancreatic Cancer

    phase 2 small molecule completed

    1 trial

  27. OMP-59R5

    Mereo BioPharma Group plc

    Stage IV Small Cell Lung Cancer

    phase 2 small molecule terminated

    1 trial

  28. ONC201

    Jazz Pharmaceuticals Ireland Limited

    Advanced Glioblastoma

    phase 2 small molecule terminated

    1 trial

  29. ONC201

    Jazz Pharmaceuticals Ireland Limited

    Multiple Myeloma

    phase 2 small molecule terminated

    1 trial

  30. ONC201

    Jazz Pharmaceuticals Ireland Limited

    Meningioma

    phase 2 small molecule terminated

    1 trial

  31. ONC201

    Jazz Pharmaceuticals Ireland Limited

    Diffuse Intrinsic Pontine Glioma

    phase 2 small molecule active

    1 trial

  32. ONC201, Paxalisib

    AXIM BIOTECHNOLOGIES, INC.

    Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs)

    phase 2 small molecule active

    1 trial

  33. ONC206

    Jazz Pharmaceuticals Ireland Limited

    Advanced Pheochromocytoma and Paraganglioma

    phase 2 small molecule active

    1 trial

  34. ONCOVIN 1 mg, solution injectable, CARBOPLATINE TEVA 10 mg/ml, solution pour perfusion, ENDOXAN 1000 mg, poudre pour solution injectable, ETOPOSIDE TEVA 20 mg/ml, solution à diluer pour perfusion, TEPADINA 15 mg powder for concentrate for solution for infusion, THIOTEPA GENOPHARM 15 mg, lyophilisat pour usage parentéral

    The George Institute

    Retinoblastoma

    phase 2 small molecule active

    1 trial

  35. OND-PR002 and MPh-IR

    BRIGHT MINDS BIOSCIENCES INC.

    Methamphetamine Dependence

    phase 2 small molecule completed

    1 trial

  36. ONDANSETRON , APREPITANT , PALONOSETRON, COMBINATIONS, PALONOSETRON , Lagipra, GRANISETRON , DEXAMETHASONE , 0.9% sodium chloride

    Eli Lilly Co.

    Nausea, Drug-Related Side Effects and Adverse Reactions, Vomiting, Neoplasms

    phase 2 small molecule active

    1 trial

  37. ONO-4578

    Ono Pharmaceutical Co.,

    Colorectal Cancer

    phase 2 small molecule active

    1 trial

  38. ONO-4578, ONO-4578, BEVACIZUMAB, ONO-4578, CALCIUM FOLINATE, OXALIPLATIN, OPDIVO 10 mg/mL concentrate for solution for infusion., FLUOROURACIL

    Lacuna Pharma Pty Ltd

    PD-L1 positive advanced colorectal cancer

    phase 2 small molecule active

    1 trial

  39. OP-1250

    Olema Pharmaceuticals

    Hormone Receptor Positive Breast Carcinoma

    phase 2 small molecule completed

    1 trial

  40. OPC-34712

    Otsuka Beijing Research Institute

    Schizophrenia

    phase 2 small molecule completed

    1 trial

  41. OPDIVO 10 mg/mL concentrate for solution for infusion.

    The George Institute

    Relapsing/Refractory ALK+ Anaplastic Large cell Lymphoma

    phase 2 small molecule active

    1 trial

  42. OPDIVO 10 mg/mL concentrate for solution for infusion.

    Ningbo Cancer Hospital

    Early stage triple negative breast cancer

    phase 2 small molecule active

    1 trial

  43. OPDIVO 10 mg/mL concentrate for solution for infusion., Anti-Fucosyl GM1 PET Tracer, ETOPOSIDE, CARBOPLATIN

    Bristol-Myers Squibb Australia Pty Ltd

    Extensive-stage Small Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  44. OPDIVO 10 mg/mL concentrate for solution for infusion., BDC-1001, OPDIVO 10 mg/mL concentrate for solution for infusion., OPDIVO 10 mg/mL concentrate for solution for infusion.

    Bolt Biotherapeutics

    Advanced HER2-Expressing Solid Tumors.

    phase 2 small molecule active

    1 trial

  45. OPDIVO 10 mg/mL concentrate for solution for infusion., FLUOROURACIL , Oxaliplatino Sandoz, LEDERFOLIN 175 mg polvere per soluzione per infusione, FLUOROURACIL , SIMVASTATIN, CAPECITABINE

    Fondazione Telethon ETS

    advanced or metastatic gastrooesophageal carcinoma HER2 negative and ARID1A mutated

    phase 2 small molecule active

    1 trial

  46. OPDIVO 10 mg/mL concentrate for solution for infusion., Inrebic 100 mg hard capsules

    The George Institute

    Primary and secondary Myelofibrosis

    phase 2 small molecule active

    1 trial

  47. OPDIVO 10 mg/mL concentrate for solution for infusion., Ipilimumab, Ipilimumab

    Bristol-Myers Squibb Australia Pty Ltd

    Advanced or metastatic solid tumors: 1) Triple Negative Breast Cancer (TNBC) 2) Gastric Cancer (GC) 3) Pancreatic Cancer (PC) 4) Small Cell Lung Cancer (SCLC). 5) Bladder Cancer (BC) 6) Ovarian Cancer (OC)

    phase 2 small molecule active

    1 trial

  48. OPDIVO 10 mg/mL concentrate for solution for infusion., Ipilimumab, OPDIVO 10 mg/mL concentrate for solution for infusion., DARZALEX 20 mg/mL concentrate for solution for infusion, Relatlimab, Relatlimab

    Bristol-Myers Squibb Australia Pty Ltd

    MSI Negative Colorectal Cancer, MSI Positive Colorectal Cancer

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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