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Intelligence · Clinical Pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs
7,238

Quick answer

NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

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  1. INC280, INC280, JNJ-61186372

    Janssen-Cilag International N.V.

    Unresectable Metastatic Non-small Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  2. INCAGN02385, Retifanlimab (INCMGA00012), INCAGN02390

    Incyte

    In participants with PD-L1–positive and systemic therapy–naive R/M SCCHN.

    phase 2 small molecule active

    1 trial

  3. INCB000928, Placebo

    Incyte

    Fibrodysplasia Ossificans Progressiva

    phase 2 small molecule active

    1 trial

  4. INCB099280, Adagrasib

    Incyte

    Advanced Solid Tumors Harboring a KRASG12C Mutation

    phase 2 small molecule active

    1 trial

  5. INDOCYANINE GREEN

    The George Institute

    Patients with primary invasive early breast cancer (T1-T2) that will undergo planned breast-conserving surgery

    phase 2 small molecule active

    1 trial

  6. INDOCYANINE GREEN

    Fondazione Telethon ETS

    Patients with gynecological cancers undergoing pelvic exenteration

    phase 2 small molecule active

    1 trial

  7. INDV-2000

    Indivior Pty Ltd

    Opioid Use Disorder

    phase 2 small molecule completed

    1 trial

  8. INDV-6001

    Indivior Pty Ltd

    Moderate to Severe Opioid Use Disorder

    phase 2 small molecule completed

    1 trial

  9. INEBILIZUMAB

    Elan Pharma International

    Neuromyelitis optica spectrum disorder (NMOSD; also known as Devic's syndrome and previously known as neuromyelitis optica [NMO])

    phase 2 small molecule active

    1 trial

  10. INF904

    InflaRx GmbH

    Moderate to Severe Chronic Spontaneous Urticaria (CSU) or Moderate to Severe Hidradenitis Suppurativa (HS)

    phase 2 small molecule active

    1 trial

  11. INFLIXIMAB , TOCILIZUMAB , Cosentyx 300 mg solution for injection in pre-filled pen, ADALIMUMAB

    Pari Pharma GmbH

    TAkayasu ARteritiS

    phase 2 small molecule active

    1 trial

  12. INFLIXIMAB, DS-8201a, IMFINZI 50 mg/mL concentrate for solution for infusion., MYCOPHENOLATE MOFETIL, PERTUZUMAB

    AstraZeneca AB

    HER2-positive Metastatic Breast Cancer

    phase 2 small molecule active

    1 trial

  13. INFLIXIMAB, FOLINIC ACID, IRINOTECAN HYDROCHLORIDE TRIHYDRATE, CALCIUM FOLINATE, MYCOPHENOLATE MOFETIL, volrustomig, FLUOROURACIL, BEVACIZUMAB

    AstraZeneca AB

    ​​Colorectal cancer​

    phase 2 small molecule active

    1 trial

  14. INFLIXIMAB, RoActemra 20 mg/mL concentrate for solution for infusion

    Pari Pharma GmbH

    Takayasu arteritis

    phase 2 small molecule active

    1 trial

  15. INM-755 (cannabinol) cream

    InMed Pharmaceuticals

    Epidermolysis Bullosa Simplex

    phase 2 small molecule completed

    1 trial

  16. INO-3107

    INOVIO PHARMACEUTICALS, INC.

    Respiratory Papillomatosis

    phase 2 small molecule completed

    1 trial

  17. INO-3112

    INOVIO PHARMACEUTICALS, INC.

    Cervical Cancer

    phase 2 mab completed

    1 trial

  18. INO-3112

    INOVIO PHARMACEUTICALS, INC.

    Head and Neck Squamous Cell Cancer

    phase 2 mab completed

    1 trial

  19. INO-3112 vaccine

    INOVIO PHARMACEUTICALS, INC.

    Uterine Cervical Neoplasms

    phase 2 mab terminated

    1 trial

  20. INO-4700

    INOVIO PHARMACEUTICALS, INC.

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

    phase 2 small molecule completed

    1 trial

  21. INO-5401

    INOVIO PHARMACEUTICALS, INC.

    Urothelial Carcinoma

    phase 2 mab completed

    1 trial

  22. INO-5401

    INOVIO PHARMACEUTICALS, INC.

    Glioblastoma

    phase 2 mab active

    1 trial

  23. INT230-6

    INTENSITY THERAPEUTICS, INC.

    Breast Cancer

    phase 2 small molecule active

    2 trials

  24. INTERFERON GAMMA , TOCILIZUMAB , DALTEPARIN , HEPARIN , BARICITINIB, FLUDROCORTISONE , HYDROCORTISONE, OCTAPLASLG, solution pour perfusion, BARICITINIB, ANAKINRA , FILGRASTIM

    Pari Pharma GmbH

    Sepsis

    phase 2 small molecule active

    1 trial

  25. INXN-2001

    Alaunos Therapeutics

    Melanoma

    phase 2 mab completed

    1 trial

  26. INZ-701

    Lacuna Pharma Pty Ltd

    Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Deficiency and ATP-binding cassette sub-family C member 6 (ABCC6) Deficiency, Generalized Arterial Calcification of Infancy (GACI), Pseudoxanthoma elasticum (PXE)

    phase 2 small molecule active

    1 trial

  27. IO102

    IO Biotech

    NSCLC

    phase 2 mab completed

    1 trial

  28. IO102-IO103

    IO Biotech

    Melanoma

    phase 2 small molecule active

    2 trials

  29. IO102-IO103 in combination with pembrolizumab

    IO Biotech

    Lung Cancer Non Small Cell

    phase 2 small molecule completed

    1 trial

  30. IO102-IO103, KEYTRUDA 25 mg/mL concentrate for solution for infusion

    IO Biotech

    Metastatic Squamous Cell Carcinoma of Head and Neck (SCCHN), Metastatic Urothelial Bladder Cancer (mUBC), Metastatic Non-Small Cell Lung Cancer (NSCLC)

    phase 2 small molecule active

    1 trial

  31. IOBENGUANE (123I) , 68Ga-SSO120

    AXIM BIOTECHNOLOGIES, INC.

    neuroblastoma

    phase 2 small molecule active

    1 trial

  32. IOBENGUANE (123I) , [18F]meta-fluorobenzylguanidine

    AXIM BIOTECHNOLOGIES, INC.

    (suspision on) Neuroblastoma

    phase 2 small molecule active

    1 trial

  33. IOHEXOL , Placebo to match LY3437943, Retatrutide

    Eli Lilly Co.

    Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

    phase 2 small molecule active

    1 trial

  34. ION-682884

    IONIS PHARMACEUTICALS INC

    Healthy Volunteers

    phase 2 small molecule completed

    1 trial

  35. ION-827359

    IONIS PHARMACEUTICALS INC

    Chronic Bronchitis

    phase 2 small molecule terminated

    1 trial

  36. ION224

    IONIS PHARMACEUTICALS INC

    Steatohepatitis, Nonalcoholic

    phase 2 small molecule completed

    1 trial

  37. ION337

    IONIS PHARMACEUTICALS INC

    Dravet Syndrome

    phase 2 small molecule active

    1 trial

  38. ION373, Artificial Cerebrospinal Fluid (aCSF) for injection

    IONIS PHARMACEUTICALS INC

    Alexander Disease

    phase 2 small molecule active

    1 trial

  39. ION440

    IONIS PHARMACEUTICALS INC

    Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome

    phase 2 small molecule active

    1 trial

  40. ION440

    IONIS PHARMACEUTICALS INC

    Methyl CpG binding protein 2 (MECP2) Duplication Syndrome (MDS)

    phase 2 small molecule active

    1 trial

  41. ION582

    IONIS PHARMACEUTICALS INC

    Angelman syndrome

    phase 2 small molecule active

    1 trial

  42. ION717

    IONIS PHARMACEUTICALS INC

    Prion Disease

    phase 2 small molecule active

    1 trial

  43. ION775

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 2 small molecule active

    1 trial

  44. ION904

    IONIS PHARMACEUTICALS INC

    Hypertension

    phase 2 small molecule completed

    1 trial

  45. IONIS DGAT2Rx

    IONIS PHARMACEUTICALS INC

    Hepatic Steatosis

    phase 2 small molecule completed

    1 trial

  46. IONIS GHR-LRx

    IONIS PHARMACEUTICALS INC

    Acromegaly

    phase 2 small molecule completed

    2 trials

  47. IONIS-AGT-LRx

    IONIS PHARMACEUTICALS INC

    Chronic Heart Failure With Reduced Ejection Fraction

    phase 2 small molecule completed

    1 trial

  48. IONIS-DMPKRx

    IONIS PHARMACEUTICALS INC

    Myotonic Dystrophy Type 1

    phase 2 small molecule completed

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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