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Intelligence · Clinical Pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs
7,238

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NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

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  1. ZW25 (Zanidatamab)

    Jazz Pharmaceuticals Ireland Limited

    HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer

    phase 2 small molecule completed

    1 trial

  2. ZW25 (Zanidatamab)

    BEONE MEDICINES AUS PTY LTD

    HER2-amplified Biliary Tract Cancers

    phase 2 small molecule completed

    1 trial

  3. ZYN002

    Harmony Biosciences Holdings

    22Q11.2 Deletion Syndrome

    phase 2 small molecule completed

    1 trial

  4. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    Non-Small Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  5. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    Breast Cancer

    phase 2 small molecule active

    1 trial

  6. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    Gastroesophageal Adenocarcinoma

    phase 2 small molecule active

    1 trial

  7. Zanidatamab

    Jazz Pharmaceuticals Ireland Limited

    HER2-positive Breast Cancer

    phase 2 small molecule active

    1 trial

  8. Zanidatamab

    ALX ONCOLOGY HOLDINGS INC

    HER2-expressing Cancers

    phase 2 small molecule completed

    1 trial

  9. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Mature B-cell Malignancies

    phase 2 small molecule completed

    1 trial

  10. Zanubrutinib

    Wuhan Createrna Science and Technology Co., Ltd

    Cold agglutinin disease

    phase 2 small molecule active

    1 trial

  11. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Refractory/Relapsed Autoimmune Hemolytic Anemia

    phase 2 small molecule active

    1 trial

  12. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Mantle Cell Lymphoma

    phase 2 small molecule active

    1 trial

  13. Zanubrutinib

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Immune Thrombocytopenia

    phase 2 small molecule active

    1 trial

  14. Zanubrutinib

    The First People's Hospital of Lianyungang

    Chronic Lymphocytic Leukemia

    phase 2 small molecule active

    1 trial

  15. Zanubrutinib

    The First People's Hospital of Lianyungang

    Non Hodgkin Lymphoma

    phase 2 small molecule active

    1 trial

  16. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Chronic Lymphocytic Leukemia (CLL)

    phase 2 small molecule active

    1 trial

  17. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

    phase 2 small molecule completed

    1 trial

  18. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Diffuse Large B-cell Lymphoma (DLBCL)

    phase 2 small molecule active

    1 trial

  19. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Follicular Lymphoma

    phase 2 small molecule active

    1 trial

  20. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Mantle Cell Lymphoma

    phase 2 small molecule active

    1 trial

  21. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Relapsed/Refractory Follicular Non-Hodgkin Lymphoma

    phase 2 small molecule completed

    1 trial

  22. Zanubrutinib

    BEONE MEDICINES AUS PTY LTD

    Relapsed Diffuse Large B-cell Lymphoma

    phase 2 small molecule completed

    1 trial

  23. Zanubrutinib+Rituximab+Lenalidomide

    The First People's Hospital of Lianyungang

    Diffuse Large B Cell Lymphoma

    phase 2 small molecule active

    1 trial

  24. Zanubrutinib, BGB-11417, BGB-11417

    BEONE MEDICINES AUS PTY LTD

    previously untreated WM, Relapsed/Refractory Waldenström’s Macroglobulinemia

    phase 2 small molecule active

    1 trial

  25. Zanubrutinib, Fludarabine, cyclophosphamide and rituximab

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Chronic Lymphocytic Leukemia

    phase 2 small molecule active

    1 trial

  26. Zarzio 30 MU/0.5 ml solution for injection or infusion in pre-filled syringe, Gilteritinib, ARA-cell® 40 mg Injektion 20 mg/ml Injektionslösung / Konzentrat zur Herstellung einer Infusionslösung, Gilteritinib, Bendarabin 50 mg Pulver zur Herstellung einer Injektions- oder Infusionslösung, Citarabina Hikma 1 g/10mL Soluzione Iniettabile

    Astellas Pharma GmbH

    FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)

    phase 2 small molecule active

    1 trial

  27. Zasocitinib

    Takeda

    Crohn's Disease

    phase 2 small molecule active

    2 trials

  28. Zasocitinib

    Takeda

    Nonsegmental Vitiligo

    phase 2 small molecule active

    1 trial

  29. Zasocitinib (Dose A)

    Takeda

    Hidradenitis Suppurativa

    phase 2 small molecule active

    1 trial

  30. Zaunbrutinib, Bendamustine and Rituximab for induction therapy

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Waldenström Macroglobulinemia (WM)

    phase 2 small molecule active

    1 trial

  31. Zejula 100 mg film-coated tablets, Zejula 100 mg film-coated tablets

    GlaxoSmithKline

    Neoplasms

    phase 2 small molecule active

    1 trial

  32. Zejula 100 mg hard capsules, Zejula 100 mg film-coated tablets, JEMPERLI 500 mg concentrate for solution for infusion

    Ningbo Cancer Hospital

    metastatic or recurrent endometrial or ovarian carcinosarcoma

    phase 2 small molecule active

    1 trial

  33. Zelboraf 240 mg film-coated tablets

    Ningbo Cancer Hospital

    Patients with metastatic or unresectable locally advanced malignancies harboring BRAF genomic alterations, the biological target of vemurafenib, and who are no more amenable to curative treatment

    phase 2 small molecule active

    1 trial

  34. Zelenectide Pevedotin, BT8009

    BICYCLE THERAPEUTICS

    Advanced or Metastatic Non-small Cell Lung Cancer

    phase 2 small molecule active

    1 trial

  35. Zelvina 10 mg hard capsules, Zelvina 25 mg hard capsules, MINJUVI 200 mg powder for concentrate for solution for infusion, Zelvina 5 mg hard capsules

    Incyte

    Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

    phase 2 small molecule active

    1 trial

  36. Zemplar (paricalcitol ) capsules

    Abbott Australasia Pty Ltd

    Diabetic Nephropathy

    phase 2 small molecule completed

    1 trial

  37. Zentalis

    Zentalis Pharmaceuticals

    Advanced Pancreatic Adenocarcinoma

    phase 2 small molecule active

    1 trial

  38. Zercepac 150 mg powder for concentrate for solution for infusion., KEYTRUDA 25 mg/mL concentrate for solution for infusion, Gemcitabin-GRY 1000 mg Pulver zur Herstellung einer Infusionslösung, Cisplatin Teva® 1 mg/ml Konzentrat zur Herstellung einer Infusionslösung

    The George Institute

    cholangiocarcinoma or gallbladder carcinoma

    phase 2 small molecule active

    1 trial

  39. Zibotentan, DAPAGLIFLOZIN, Zibotentan placebo, Dapagliflozin placebo

    AstraZeneca AB

    Cirrhosis of the liver is a condition in which the liver is scarred and damaged

    phase 2 small molecule active

    1 trial

  40. Ziftomenib

    Kura Oncology

    Advanced Malignant Neoplasm

    phase 2 small molecule active

    1 trial

  41. Ziftomenib, Ziftomenib

    Kura Oncology

    Relapsed and/or refractory Acute Myeloid Leukemia

    phase 2 small molecule active

    1 trial

  42. Zilebesiran

    Alnylam Netherlands B.V.

    Mild to Moderate Hypertension

    phase 2 small molecule completed

    1 trial

  43. Zilebesiran

    Alnylam Netherlands B.V.

    High Cardiovascular Risk

    phase 2 small molecule completed

    1 trial

  44. Zilovertamab vedotin

    Merck Sharp and Dohme

    Hematologic Malignancies or Solid Tumors in Pediatric and Young Adults

    phase 2 small molecule active

    1 trial

  45. Zilretta

    Pacira Ireland Limited

    Osteoarthritis of Hip

    phase 2 small molecule terminated

    1 trial

  46. Zimberelimab

    Arcus Biosciences

    Pancreatic Ductal Adenocarcinoma

    phase 2 small molecule active

    1 trial

  47. Zimberelimab

    Arcus Biosciences

    Melanoma

    phase 2 small molecule active

    1 trial

  48. Zimberelimab

    Arcus Biosciences

    Hepatobiliary Cancer

    phase 2 small molecule active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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