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Intelligence · Clinical Pipeline

Phase II Pipeline Programs

Proof-of-concept and dose-finding clinical programs in Phase II development.

Programs
7,238

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NovaPharmaNews tracks 7,238 phase ii pharmaceutical pipeline programs from ClinicalTrials.gov. Proof-of-concept and dose-finding clinical programs in Phase II development.

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  1. RO7790121, RO7790121 placebo/diluent

    Hoffmann-La Roche

    Atopic Dermatitis

    phase 2 small molecule active

    1 trial

  2. RO7881583, EMPAGLIFLOZIN, Fulvestrant EVER Pharma 250 mg Injektionslösung in einer Fertigspritze, SACITUZUMAB GOVITECAN , Verzenios 100 mg film-coated tablets, EMPAGLIFLOZIN, PALBOCICLIB, INAVOLISIB, Tecentriq 1 200 mg concentrate for solution for infusion, LETROZOLE ACCORD HEALTHCARE 2,5 mg, comprimé pelliculé, PALBOCICLIB, PALBOCICLIB, RoActemra 20 mg/mL concentrate for solution for infusion, Kisqali 200 mg film-coated tablets, Verzenios 50 mg film-coated tablets, Tecentriq, Abraxane 5 mg/ml powder for di

    Hoffmann-La Roche

    Metastatic breast cancer, including triple negative breast cancer (TNBC), hormone receptor positive breast cancer (HR+ BC), and HER2 positive and HER2 low breast cancer (HER2+/HER2-low BC)

    phase 2 small molecule active

    1 trial

  3. ROT-TDS, Neupro 8 mg/24 h transdermal patch, Neupro 8 mg/24 h transdermal patch

    Lacuna Pharma Pty Ltd

    Parkinson's disease

    phase 2 small molecule active

    1 trial

  4. RP-A501

    Rocket Pharmaceuticals B.V.

    Danon Disease

    phase 2 gene therapy active

    2 trials

  5. RP-L102

    Rocket Pharmaceuticals B.V.

    Fanconi Anemia Complementation Group A

    phase 2 mab active

    3 trials

  6. RP-L201

    Rocket Pharmaceuticals B.V.

    Leukocyte Adhesion Defect - Type I

    phase 2 mab completed

    2 trials

  7. RP-L301

    Rocket Pharmaceuticals B.V.

    Pyruvate Kinase Deficiency

    phase 2 mab on hold

    2 trials

  8. RP5063

    REVIVA PHARMACEUTICALS HOLDINGS, INC.

    Acute Schizophrenia

    phase 2 small molecule completed

    1 trial

  9. RTA 408 Capsule, 10 mg, Skyclarys 50 mg hard capsules, RTA 408 Capsule, 2.5 mg, Skyclarys 50 mg hard capsules

    Lacuna Pharma Pty Ltd

    Friedreich's ataxia

    phase 2 small molecule active

    1 trial

  10. RTP-026 Placebo, RTP-026

    Lacuna Pharma Pty Ltd

    Patients with ST-Elevation Myocardial Infarction (STEMI)

    phase 2 small molecule active

    1 trial

  11. RTS,S/AS01B (50mcg of RTS,S and standard adult dose of AS01)

    United Therapeutics Europe Ltd

    Plasmodium Falciparum Malaria

    phase 2 mab completed

    1 trial

  12. RUBIDIUM CHLORIDE

    Pari Pharma GmbH

    Kidney carcinoma

    phase 2 small molecule active

    1 trial

  13. RX-3117

    Processa Pharmaceuticals

    Metastatic Pancreatic Cancer

    phase 2 small molecule completed

    1 trial

  14. RX-3117

    Processa Pharmaceuticals

    Solid Tumor

    phase 2 small molecule completed

    1 trial

  15. Rabipur Polvere e solvente per soluzione iniettabile in siringa preriempita. Vaccino rabico (inattivato)., TICOVAC 0,25 ml per uso pediatrico Sospensione iniettabile in una siringa preriempita Vaccino (virus intero, inattivato) contro l'encefalite da zecca, AUTOLOGOUS PERIPHERAL BLOOD-DERIVED CD4+ T-CELLS CRISPR-EDITED AT THE CD40LG LOCUS, Infanrix hexa, Powder and suspension for suspension for injection. Diphtheria (D), tetanus (T), pertussis (acellular, component) (Pa), hepatitis B (rDNA) (HBV), poliomye

    Fondazione Telethon ETS

    X-linked immunodeficiency with hyper-IgM type 1 (HIGM1)

    phase 2 small molecule active

    1 trial

  16. Rademikibart in prefilled syringe

    S.L

    COPD Acute Exacerbation

    phase 2 other active

    1 trial

  17. Rademikibart in prefilled syringe

    S.L

    Asthma Acute

    phase 2 other active

    1 trial

  18. Radiation+PD-1 Ab

    The First People's Hospital of Lianyungang

    Proton Therapy

    phase 2 other active

    1 trial

  19. Radiation: 131I-MIBG

    United Therapeutics Europe Ltd

    Neuroblastoma

    phase 2 small molecule active

    1 trial

  20. Radiation: Proton Therapy+PD-1 Ab

    The First People's Hospital of Lianyungang

    Proton Therapy

    phase 2 other active

    1 trial

  21. Radiation: Radiation Therapy；Biological: Personalized tumor peptide vaccine

    Hospital Authority, Hong Kong

    Advanced Tumors

    phase 2 other active

    1 trial

  22. Radio-guided sentinel node biopsy

    Hospital Authority, Hong Kong

    Cancer of the Breast

    phase 2 other terminated

    1 trial

  23. Radiochemoimmunotherapy

    The First People's Hospital of Lianyungang

    Gastric Cancer

    phase 2 other active

    1 trial

  24. Radiotherapy

    The First People's Hospital of Lianyungang

    Cholangiocarcinoma

    phase 2 other terminated

    1 trial

  25. Radiotherapy Combined with Anlotinib and a Microtubule Inhibitor

    The First People's Hospital of Lianyungang

    HER2-Negative Breast Cancer

    phase 2 small molecule active

    1 trial

  26. Radiotherapy plus temozolomide

    The First People's Hospital of Lianyungang

    Glioma (Any Grade) in the Brain

    phase 2 small molecule active

    1 trial

  27. Radium-223 dichloride (Xofigo, BAY88-8223)

    Bayer HealthCare AG

    Breast Neoplasms

    phase 2 small molecule completed

    1 trial

  28. Radotinib HCl, Placebo for Radotinib HCl

    Alphapharm Pty Ltd

    Treatment of Parkinson’s disease (PD)

    phase 2 small molecule active

    1 trial

  29. Ralinepag

    United Therapeutics Europe Ltd

    Pulmonary Arterial Hypertension

    phase 2 small molecule completed

    1 trial

  30. Raltitrexed

    The First People's Hospital of Lianyungang

    Inoperable Esophageal Cancer Stage I-III

    phase 2 small molecule active

    1 trial

  31. Raludotatug Deruxtecan

    Daiichi Sankyo

    Advanced/metastatic solid tumors including gynecological cancers (endometrial cancer, cervical cancer, and nonhigh- grade serous ovarian cancer) and genitourinary cancers (urothelial cancer and ccRCC)

    phase 2 small molecule active

    1 trial

  32. Raludotatug Deruxtecan (R-DXd)

    Merck KGaA, Darmstadt, Germany

    Gastrointestinal Cancer

    phase 2 mab active

    1 trial

  33. Ramelteon

    Takeda

    Sleep Disorder

    phase 2 small molecule completed

    1 trial

  34. Ramelteon

    Takeda

    Migraine

    phase 2 small molecule terminated

    1 trial

  35. Ramelteon

    Takeda

    Sleep Disorders, Circadian Rhythm

    phase 2 small molecule completed

    1 trial

  36. Ramelteon

    BRIGHT MINDS BIOSCIENCES INC.

    Tobacco Use Disorder

    phase 2 small molecule completed

    1 trial

  37. Ramelteon and Placebo (25 possible combinations total)

    Takeda

    Chronic Insomnia

    phase 2 small molecule completed

    1 trial

  38. Ramelteon and doxepin

    Takeda

    Sleep Initiation and Maintenance Disorders

    phase 2 small molecule completed

    1 trial

  39. Ramelteon and gabapentin

    Takeda

    Sleep Initiation and Maintenance Disorders

    phase 2 small molecule completed

    1 trial

  40. Ramelteon or Placebo

    Takeda

    Sleep Apnea, Obstructive

    phase 2 small molecule completed

    1 trial

  41. Ramelteon, triazolam, and placebo (56 possible combinations total)

    Takeda

    Drug Abuse

    phase 2 small molecule completed

    1 trial

  42. Ramipril

    Quantum Biopharma

    Myocardial Infarction

    phase 2 small molecule completed

    1 trial

  43. Ramucirumab

    Eli Lilly and Company

    Gastric Adenocarcinoma

    phase 2 small molecule completed

    1 trial

  44. Randomized phase 2 trial of two chemotherapy regimens plus or minus bevacizumab in patients with well differentiated pancreatic neuroendocrine tumors

    The George Institute

    Pancreatic well differentiated neuroendocrine tumors (NET)

    phase 2 other active

    1 trial

  45. Randomized: 40 mg Paltusotine

    Crinetics Pharmaceuticals Europe GmbH

    Carcinoid Syndrome

    phase 2 small molecule completed

    1 trial

  46. Rapamune 1 mg/mL oral solution

    Tour Hekla

    Lingual microcystic lymphatic malformations (LMLMs) are rare congenital vascular malformations, presenting as clusters of cysts filled with lymph fluid or blood. They are responsible for a heavy burden even with small well-limited lesions because of oozing, bleeding, infections, or even speech, chewing or breathing impairment. Pain and aesthetic prejudice are also frequently reported

    phase 2 small molecule active

    1 trial

  47. Rapamune 1 mg/mL oral solution, Rapamune 0.5 mg coated tablets, Co-Trimoxazole Forte 160/800mg Tablets, Rapamune 2 mg coated tablets, adeno-associated virus, serotype 9 (AAV9), PREDNISONE VIATRIS 5 mg, comprimé sécable, PREDNISONE VIATRIS 1 mg, comprimé, PREDNISONE VIATRIS 20 mg, comprimé sécable, Prednisone Olikla 2.5 mg tablety, Prednisone Olikla 10 mg tablety, Prednisone Olikla 50 mg tablety, Rapamune 1 mg coated tablets

    Alexion Europe SAS

    BAG3 Mutation Associated Dilated Cardiomyopathy

    phase 2 small molecule active

    1 trial

  48. Rapcabtagene autoleucel

    Novartis Pharmaceuticals

    ANCA Associated Vasculitis (AAV)

    phase 2 mab active

    1 trial

Frequently asked questions

How many Phase II pipeline programs are in the directory?

7,238 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

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