🇺🇸 FDA

Intelligence · Clinical Pipeline

Phase I Pipeline Programs

First-in-human and early clinical safety studies in Phase I.

Programs
4,713

Quick answer

NovaPharmaNews tracks 4,713 phase i pharmaceutical pipeline programs from ClinicalTrials.gov. First-in-human and early clinical safety studies in Phase I.

Top sponsors

Page 8 of 99

  1. A Study to Investigate the Effect of RO7504109 on Immune Cells in Healthy Participants

    Hoffmann-La Roche

    Not Applicable (N/A)

    phase 1 other active

    1 trial

  2. A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants with Advanced Solid Tumors Previously Treated with Standard of Care Therapy

    AstraZeneca AB

    Advanced Solid Tumors

    phase 1 other active

    1 trial

  3. A Study to Investigate the Pharmacokinetics, Safety and Tolerability of AZD5462 in Participants with Renal Impairment

    AstraZeneca AB

    Impaired renal function

    phase 1 other active

    1 trial

  4. A Study to Investigate the Response of Participants With Type 2 Diabetes Mellitus on Once-Weekly Retatrutide to Hypoglycemia

    Eli Lilly Co.

    Type 2 Diabetes Mellitus

    phase 1 other active

    1 trial

  5. A Study to Investigate the Safety and Tolerability of Ziftomenib Combinations in Patients with Relapsed/Refractory Acute Myeloid Leukemia

    Kura Oncology

    Relapsed and/or refractory Acute Myeloid Leukemia

    phase 1 other active

    1 trial

  6. A Study to Investigate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of Ascending Intravenous Doses of Glofitamab, Administered after Ocrelizumab Pretreatment, in Patients with Multiple Sclerosis

    Hoffmann-La Roche

    Multiple Sclerosis (MS)

    phase 1 other active

    1 trial

  7. A Study to Investigate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of RO7121932 following Intravenous and Subcutaneous Administration in Participants with Multiple Sclerosis

    Hoffmann-La Roche

    Multiple Sclerosis (MS)

    phase 1 other active

    1 trial

  8. A Study to Learn About How Different Formulations of the Medicine Called Mevrometostat are Taken up Into the Blood in Healthy Adult Participants

    Pfizer Australia Pty Ltd

    Small cell lung cancer, Castration-resistant prostate cancer, Follicular lymphoma

    phase 1 other active

    1 trial

  9. A Study to Learn About if the Study Medicine Called Ibuzatrelvir changes how the body process the other Medicine Dabigatran Etexilate in healthy adults

    Pfizer Australia Pty Ltd

    severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

    phase 1 other active

    1 trial

  10. A Study to Learn About the Study Medicine Called PF-07054894 in People of Japanese Origin

    Pfizer Australia Pty Ltd

    Inflammatory bowel disease

    phase 1 other active

    1 trial

  11. A Study to Learn About the Study Medicine Called PF-07258669 in Older Adults Including Those at Risk of Malnutrition

    Pfizer Australia Pty Ltd

    Older adults at risk of malnutrition

    phase 1 other active

    1 trial

  12. A Study to Learn How Different Amounts of the Study Medicine Called PF-07293893 are Tolerated and Act in the Body of Healthy Adults.

    Pfizer Australia Pty Ltd

    heart failure with preserved ejection fraction

    phase 1 other active

    1 trial

  13. A Study to Learn How Different Amounts of the Study Medicine Called PF-07328948 are Tolerated and Act in the Body in Healthy Adults

    Pfizer Australia Pty Ltd

    Heart failure

    phase 1 other active

    1 trial

  14. A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 are Tolerated and Act in the Body in Healthy Adults

    Pfizer Australia Pty Ltd

    Clonal hematopoiesis

    phase 1 other active

    1 trial

  15. A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 are Tolerated and Act in the Body in Healthy Adults.

    Pfizer Australia Pty Ltd

    clonal hematopoiesis

    phase 1 other active

    1 trial

  16. A Study to Learn How Different Amounts of the Study Medicine Called PF-07985631 are Tolerated and Act in the Body in Healthy Adults

    Pfizer Australia Pty Ltd

    IgA nephropathy

    phase 1 other active

    1 trial

  17. A Study to Learn How Different Amounts of the Study Medicine Called PF-07999415 are Tolerated and Act in the Body in Healthy Adults

    Pfizer Australia Pty Ltd

    CCI

    phase 1 other active

    1 trial

  18. A Study to Learn How Different Amounts of the Study Medicine Called PF-08065010 are Tolerated and Act in the Body of Healthy Adults

    Pfizer Australia Pty Ltd

    Rheumatoid arthritis and Systemic Lupus Erythematosus

    phase 1 other active

    1 trial

  19. A Study to Learn How Different Forms of The Study Medicine Called Prazosin Are Taken up Into the Blood in Healthy Adults

    Pfizer Australia Pty Ltd

    Primary and secondary hypertension, and heart failure

    phase 1 other active

    1 trial

  20. A Study to Learn How Different Injector Pens Affect the Study Medicine Called Genotropin® (somatropin) Delivery and Taken Up Into the Blood in Healthy Adults

    Pfizer Australia Pty Ltd

    Growth hormone deficiency

    phase 1 other active

    1 trial

  21. A Study to Learn How Enzalutamide, Apalutamide and Bicalutamide Affect the Way Fezolinetant is Processed by the Body in Men With Prostate Cancer

    Astellas Pharma GmbH

    Hot Flush

    phase 1 other active

    1 trial

  22. A Study to Learn How a Tablet Compared with an IV Infusion of the Study Medicine Called Vepdegestrant is Taken up into the Blood in Healthy Adults.

    Pfizer Australia Pty Ltd

    ER+/HER2- breast cancer

    phase 1 other active

    1 trial

  23. A Study to Learn How the Study Medicine Called Ibuzatrelvir is Taken up into the Blood of Healthy Adults After Taking Different Tablets of the Study Medicine Called Ibuzatrelvir.

    Pfizer Australia Pty Ltd

    Coronavirus disease 2019

    phase 1 other active

    1 trial

  24. A Study to Learn If The Study Medicine Called Fluconazole Changes How the Body Processes The Other Study Medicine PF-07248144

    Pfizer Australia Pty Ltd

    locally advanced or metastatic HR+/HER2- breast cancer

    phase 1 other active

    1 trial

  25. A Study to Learn If the Study Medicine Called Vepdegestrant Changes How the Body Processes the Other Study Medicine Called Midazolam

    Pfizer Australia Pty Ltd

    ER+/HER2 positive breast cancer

    phase 1 other active

    1 trial

  26. A Study to Learn More About an Investigational Medicine called HDP-102 in Patients with Relapsed/Refractory B-cell Blood Cancers.

    Lacuna Pharma Pty Ltd

    Relapsed/Refractory B-cell Malignancies

    phase 1 other active

    1 trial

  27. A Study to Learn how Various Tablets of the Study Medicine Called Vepdegestrant are Taken up into the Blood in Healthy Adults

    Pfizer Australia Pty Ltd

    ER+/HER2- Breast Cancer

    phase 1 other active

    1 trial

  28. A Study to Learn if Multiple Doses of the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine PF-07248144

    Pfizer Australia Pty Ltd

    locally advanced or metastatic ER+/HER2- breast cancer

    phase 1 other active

    1 trial

  29. A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults

    Pfizer Australia Pty Ltd

    Type 2 Diabetes Mellitus, Obesity, Overweight management

    phase 1 other active

    1 trial

  30. A Study to Test How BI 765063 and BI 770371 Are Taken up in Tumours of People With Different Types of Advanced Cancer Who Are Also Taking Ezabenlimab

    Boehringer Ingelheim

    non-small cell lung cancer or, melanoma, head and neck squamous cell carcinoma

    phase 1 other active

    1 trial

  31. A Study to Test How Safe, Effective and How Body’s Responds to the Combination of Mosunetuzumab and Pirtobrutinib Together to Treat Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia

    Hoffmann-La Roche

    Relapsed or Refractory Chronic Lymphocytic Leukemia (R/R CLL)

    phase 1 other active

    1 trial

  32. A Study to Track How the Healthy Male Participants Handles the New Oral Drug RO7795081 for Weight Management and Diabetes

    Hoffmann-La Roche

    Not Applicable

    phase 1 other active

    1 trial

  33. A Study to Understand What the Body Does to the Study Medicine Called PF-07976016 When Taken by Healthy Adults

    Pfizer Australia Pty Ltd

    Obesity, Overweight

    phase 1 other active

    1 trial

  34. A Study to assess the Safety, Tolerability and effect of RO7673396 when used alone as well as with other cancer medications in participants with Advanced Solid Tumors

    Hoffmann-La Roche

    Advanced Solid Tumors Harboring RAS Mutation(S)

    phase 1 other active

    1 trial

  35. A Study to evaluate the effect of a high-fat meal on the Pharmacokinetics of the Selective MET kinase Inhibitor DO-2 in subjects in good health

    Wuhan Createrna Science and Technology Co., Ltd

    Healthy volunteer

    phase 1 other active

    1 trial

  36. A Study to find out the safety, tolerability and interaction of drug with body (including the effect of Itraconazole on RO7268489) and also what the body does to RO7268489 after oral intake by healthy participants

    Hoffmann-La Roche

    Not applicable

    phase 1 other active

    1 trial

  37. A Study to see how safe is RO7567132 as Single Agent and in Combination with Atezolizumab, how the body gets rid of it and how effective it is in people with Advanced and/or Metastatic Solid Tumors

    Hoffmann-La Roche

    Advanced and/or Metastatic Solid Tumors

    phase 1 other active

    1 trial

  38. A Study with ABBV-155 Alone and in Combination with Taxane Therapy in Adults with Relapsed and/or Refractory Solid Tumors

    AbbVie Deutschland GmbH & Co. KG

    Patients with relapsed or refractory solid tumors, including: Small cell lung cancer (SCLC); Non-small cell cancer (NSCLC); Breast cancer

    phase 1 other active

    1 trial

  39. A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants

    Merck Sharp and Dohme

    Healthy

    phase 1 other active

    1 trial

  40. A TWO-PART ABSOLUTE BIOAVAILABILITY STUDY DESIGNED TO EVALUATE THE PHARMACOKINETIC PROFILE OF VELUSETRAG FOLLOWING SINGLE-DOSE ADMINISTRATION OF INTRAVENOUS AND ORAL CAPSULE FORMULATIONS IN HEALTHY MALE AND FEMALE SUBJECTS

    Alfasigma S.p.A.

    chronic intestinal pseudo-obstruction (CIPO)

    phase 1 other active

    1 trial

  41. A Trial Comparing Pharmacokinetics, Safety and Tolerability of Two Subcutaneous Concentrations of Dapiglutide

    Zealand Pharma A/S

    Weight management

    phase 1 other active

    1 trial

  42. A Trial to Determine if Quabodepistat is Processed Differently in Adults with Reduced Liver Function Compared to Adults with Normal Liver Function

    Otsuka Beijing Research Institute

    Tuberculosis

    phase 1 other active

    1 trial

  43. A Trial to Evaluate Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Insulin GZR4 Compared with Insulin Degludec and Insulin Icodec in Participants with Type 2 Diabetes

    Lacuna Pharma Pty Ltd

    Type 2 Diabetes Mellitus

    phase 1 other active

    1 trial

  44. A Trial to Evaluate the Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Insulin GZR33 Compared with Insulin Degludec at steady state in participants with Type 1 Diabetes

    Lacuna Pharma Pty Ltd

    Type 1 diabetes Mellitus

    phase 1 other active

    1 trial

  45. A Trial to Examine the Effects of MSP-2020 on Brain Activity in Healthy Adults

    Otsuka Beijing Research Institute

    Incomplete Response - Major Depressive Disorder (IR-MDD)

    phase 1 other active

    1 trial

  46. A bioavailability study of epinephrine following a single dose of emergency response auto-injector in comparison to epinephrine injection into muscle via syringe in healthy adults.

    Mylan Pharma UK

    Allergic reactions (Type 1), including anaphylaxis, idiopathic anaphylaxis or exercise-induced anaphylaxis

    phase 1 other active

    1 trial

  47. A clinical research study investigating how the body processes the new compound petrelintide in people with kidney problems

    Zealand Pharma A/S

    Weight management

    phase 1 other active

    1 trial

  48. A clinical study of MK-0472 in people with solid tumors (MK-0472-001)

    Merck Sharp and Dohme

    Malignant Neoplasm - Solid Tumors

    phase 1 other active

    1 trial

Frequently asked questions

How many Phase I pipeline programs are in the directory?

4,713 published programs match this development stage in our ClinicalTrials.gov index.

What defines this pipeline stage?

Phase and status reflect ClinicalTrials.gov registry fields at last sync. See our clinical trial phases reference for methodology.

Data attribution: Data sources · All pipeline programs

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.