Wednesday, July 8, 2026

Drug profile · INN

sparsentan

sparsentan (FILSPARI) is a type-1 angiotensin ii receptor antagonist. Associated with Travere Therapeutics. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Cardiovascular system (C09) C09XX01
US status approved
Patents linked 1
Pipeline programs 10
News articles 1
Drug details — sparsentan

Quick answer

sparsentan (FILSPARI) is a type-1 angiotensin ii receptor antagonist. Associated with Travere Therapeutics. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN sparsentan
Brand FILSPARI
Mechanism Type-1 angiotensin II receptor antagonist
Target Endothelin-1 receptor
Therapeutic class Cardiovascular system (C09)
Route ORAL
Formulation TABLET
ATC code C09XX01

Mechanism of action

Type-1 angiotensin II receptor antagonist

Primary target: Endothelin-1 receptor

Approval history

Authority Status Date
FDA approved
EMA approved

Recent coverage

Pipeline programs

  1. 021FSGS16010 Phase 3 · Travere Therapeutics · Focal segmental glomerulosclerosis (FSGS)
  2. 021IGAN17001 Phase 3 · Travere Therapeutics · Immunoglobulin A Nephropathy (IgAN)
  3. sparsentan Phase 3 · Travere Therapeutics · Focal Segmental Glomerulosclerosis
  4. sparsentan Phase 3 · Travere Therapeutics · Immunoglobulin A Nephropathy
  5. RE-021 (Sparsentan) Phase 2 · Travere Therapeutics · Focal Segmental Glomerulosclerosis
  6. RTRX-RE021-201 Phase 2 · Travere Therapeutics · Proteinuric glomerular diseases including: •Focal segmental
  7. Sparsentan Phase 2 · Travere Therapeutics · ANCA Associated Vasculitis
  8. RE-021, sparsentan Phase 1 · Travere Therapeutics · Healthy Subjects

Related & competitor drugs

  1. alirocumab Cardiovascular system (C10)
  2. aliskiren Cardiovascular system (C09)
  3. azilsartan medoxomil Cardiovascular system (C09)
  4. bempedoic acid Cardiovascular system (C10)
  5. bosentan Cardiovascular system (C02)
  6. dofetilide Cardiovascular system (C01)
  1. US 9993461

    Method for treating disorders associated with glomerular function

    Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is sparsentan?

sparsentan (FILSPARI) is a type-1 angiotensin ii receptor antagonist. Associated with Travere Therapeutics. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for sparsentan?

FILSPARI is a marketed brand name for sparsentan. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of sparsentan?

sparsentan has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.