Wednesday, July 8, 2026

Drug profile · INN

bempedoic acid

bempedoic acid (NILEMDO) is a atp-citrate synthase inhibitor. Associated with Esperion Therapeutics. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Cardiovascular system (C10) C10B
US status approved
Patents linked 20
Pipeline programs 16
News articles 1
Drug details — bempedoic acid

Quick answer

bempedoic acid (NILEMDO) is a atp-citrate synthase inhibitor. Associated with Esperion Therapeutics. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN bempedoic acid
Brand NILEMDO
Mechanism ATP-citrate synthase inhibitor
Target ATP-citrate synthase
Therapeutic class Cardiovascular system (C10)
Route ORAL
Formulation TABLET
ATC code C10B

Mechanism of action

ATP-citrate synthase inhibitor

Primary target: ATP-citrate synthase

Approval history

Authority Status Date
FDA approved
EMA approved

Recent coverage

Pipeline programs

  1. AMIL/25/Obi-Dys/001 Phase 3 · Menarini Asia-Pacific · Dyslipidemia at High to Very High Cardiovascular Risk
  2. Bempedoic Acid + Ezetimibe Fixed-Dose Combination Phase 3 · Esperion Therapeutics · Hyperlipidemias
  3. Bempedoic acid 180 mg tablet Phase 3 · Esperion Therapeutics · Cardiovascular Diseases
  4. MK-0616-018 Phase 3 · MSD Merck Sharp · Hypercholesterolemia
  5. bempedoic acid Phase 3 · Esperion Therapeutics · Hypercholesterolemia
  6. Bempedoic acid + Ezetimibe FDC Oral Tablet Phase 2 · Esperion Therapeutics · Diabetes
  7. Bempedoic acid 180mg Phase 2 · Esperion Therapeutics · Hypercholesterolemia
  8. Bempedoic acid, bempedoic acid Phase 2 · Esperion Therapeutics · Heterozygous familial hypercholesterolemia, Heterozygous Fam

Related & competitor drugs

  1. alirocumab Cardiovascular system (C10)
  2. aliskiren Cardiovascular system (C09)
  3. azilsartan medoxomil Cardiovascular system (C09)
  4. bosentan Cardiovascular system (C02)
  5. dofetilide Cardiovascular system (C01)
  6. dopamine hydrochloride Cardiovascular system (C01)
  1. US 12404227

    Methods of making bempedoic acid and compositions of the same

    Expires Mon Aug 28 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12398087

    Methods of making bempedoic acid and compositions of the same

    Expires Mon Aug 21 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12344578

    Salt forms of bempedoic acid and methods for using the same

    Expires Mon Jun 26 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11987548

    Methods of making bempedoic acid and compositions of the same

    Expires Mon May 16 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11926584

    Methods of making bempedoic acid and compositions of the same

    Expires Mon Mar 07 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11760714

    Methods of making bempedoic acid and compositions of the same

    Expires Mon Sep 14 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11744816

    Fixed dose combinations and formulations comprising ETC1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease

    Expires Mon Aug 31 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11613511

    Methods of making bempedoic acid and compositions of the same

    Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11407705

    Methods of making bempedoic acid and compositions of the same

    Expires Mon Aug 04 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10912751

    Fixed dose combinations and formulations comprising ETC1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease

    Expires Mon Feb 04 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 9610324

    Apolipoprotein mixtures

    Expires Mon Mar 30 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 7709515

    Compositions comprising ether compounds and pharmaceutical uses therefor

    Expires Mon Apr 29 2030 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 7335799

    Hydroxyl compounds and compositions for cholesterol management and related uses

    Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 7192940

    Ether compounds

    Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 6953840

    Methods of using non-human animal Apolipoprotein A-I protein

    Expires Mon Oct 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired
  16. US 6909014

    Intermediates for the synthesis of ether compounds

    Expires Mon Jun 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired
  17. US 6831105

    Compositions comprising ether compounds and pharmaceutical uses therefor

    Expires Mon Dec 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired
  18. US 6790953

    Ether compounds

    Expires Mon Sep 09 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired
  19. US 6646170

    Intermediates for the synthesis of ether compounds

    Expires Mon Nov 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired
  20. US 6506799

    Methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension with ether compounds

    Expires Mon Jan 09 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired

Frequently asked questions

What is bempedoic acid?

bempedoic acid (NILEMDO) is a atp-citrate synthase inhibitor. Associated with Esperion Therapeutics. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for bempedoic acid?

NILEMDO is a marketed brand name for bempedoic acid. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of bempedoic acid?

bempedoic acid has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.